Objective:To clarify altered whole brain functional connectivity of the anterior cingulate cortex(ACC)in functional dyspepsia(FD)patients,and then to explore cerebral influence of acupuncture with deqi treating for FD...Objective:To clarify altered whole brain functional connectivity of the anterior cingulate cortex(ACC)in functional dyspepsia(FD)patients,and then to explore cerebral influence of acupuncture with deqi treating for FD.Methods:Thirty-two FD patients and 35 healthy subjects(HS)were firstly scanned by the resting-state blood oxygenation level-dependent functional magnetic resonance imaging(BOLD-fMRI)to compare differences of ACC-based functional connectivity(FC).Then 32 FD patients were randomized to receive 20 sessions’acupuncture treatment with(n=16)and without deqi(n=16),as well as underwent functional magnetic resonance imaging(fMRI)scans after treatment.After group re-division according to deqi response,changes of ACC subregions-based resting-state FC(rsFC)were compared between the actual with and without deqi group.Two seeds with bilateral of each were selected as regions of interest(ROIs)of the ACC,including two from the dorsal ACC:S2(BA24)(x=±5,y=2,z=46,r=3.5 mm)and two from the pregenual ACC:17(BA24)(x=±5,y=38,z=6,r=3.5 mm).The clinical changes of the Nepean Dyspepsia Index(NDI)that measuring symptoms and quality of life(QOL)were also used to further assess the correlation with ACC subregions rsFC in FD patients.Results:Compared to HS,FD patients showed significantly increased ACC subregions rsFC with left fusiform gyrus,temporal cortex,hippocampus(HIPP)/amygdala,temporal pole,and right INS,superior occipital gyrus,and bilateral precuneus,superior parietal lobule(SPL),and decreased rsFC with left postcentral/precentral gyrus(PoG/PrG),supplementary motor area(SMA)and right cerebellum.32 FD patients which were then re-divided into the actual deqi group(n=16)and actual without deqi group(n=16).The decrease of the NDI symptom score(pre-pos)in the actual deqi group was significantly greater than that in the actual without deqi group(P<0.05).Among the two groups,the actual deqi group showed increased ACC subregions rsFC with right SMA and bilateral PrG/PoG,and decreased rsFC with right precuneus,middle occipi展开更多
任意波形发生器(又叫函数发生器)作为一种通用的信号源,在物理、电子、计算机等领域有着广泛的应用.本文提出了一种不依赖PC机总线的、完全独立的、可用于低场磁共振成像的多用途任意波形发生器(Arbitrary Wave form Generator,AWG)设...任意波形发生器(又叫函数发生器)作为一种通用的信号源,在物理、电子、计算机等领域有着广泛的应用.本文提出了一种不依赖PC机总线的、完全独立的、可用于低场磁共振成像的多用途任意波形发生器(Arbitrary Wave form Generator,AWG)设计方案,围绕着这种方案,研制了80MHz通用磁共振任意波形发生器.并提供了实际测试数据和成像实验结果,对研制情况和实验结果进行了总结和讨论.展开更多
国际医学MR学会（International Society for Magnetic Resonance in Medicine, ISMRM）创立于1994年，是全球规模最大和最具影响力的医学MR学会。第23届ISMRM年会于2015年5月30日至6月5日在加拿大多伦多召开。本次大会有来自全球70多...国际医学MR学会（International Society for Magnetic Resonance in Medicine, ISMRM）创立于1994年，是全球规模最大和最具影响力的医学MR学会。第23届ISMRM年会于2015年5月30日至6月5日在加拿大多伦多召开。本次大会有来自全球70多个国家的6000多名研究者参会，共收录口头报告1074篇，传统墙报1803篇，电子墙报1852篇，内容涵盖MR在医学、物理、生物学等方面的基础与临床研究。来自中国的研究中，南方医科大学和香港大学各一项研究荣获本次大会的“Summa Cum Laude”优秀论文奖，另外来自国内多家单位的13项研究荣获本次大会的“Manga Cure Laude”优秀论文奖。展开更多
基金grants from the National Natural Science Foundation of Outstanding Youth Fund in China:81622052National Natural Science Foundation of China:81473602+2 种基金the major program of the National Natural Science Foundation of China:81590950the Ten Thousand Talent Program:W02020595Youth Science and Technology Innovative Team of Sichuan Province:2019JDTD0011。
文摘Objective:To clarify altered whole brain functional connectivity of the anterior cingulate cortex(ACC)in functional dyspepsia(FD)patients,and then to explore cerebral influence of acupuncture with deqi treating for FD.Methods:Thirty-two FD patients and 35 healthy subjects(HS)were firstly scanned by the resting-state blood oxygenation level-dependent functional magnetic resonance imaging(BOLD-fMRI)to compare differences of ACC-based functional connectivity(FC).Then 32 FD patients were randomized to receive 20 sessions’acupuncture treatment with(n=16)and without deqi(n=16),as well as underwent functional magnetic resonance imaging(fMRI)scans after treatment.After group re-division according to deqi response,changes of ACC subregions-based resting-state FC(rsFC)were compared between the actual with and without deqi group.Two seeds with bilateral of each were selected as regions of interest(ROIs)of the ACC,including two from the dorsal ACC:S2(BA24)(x=±5,y=2,z=46,r=3.5 mm)and two from the pregenual ACC:17(BA24)(x=±5,y=38,z=6,r=3.5 mm).The clinical changes of the Nepean Dyspepsia Index(NDI)that measuring symptoms and quality of life(QOL)were also used to further assess the correlation with ACC subregions rsFC in FD patients.Results:Compared to HS,FD patients showed significantly increased ACC subregions rsFC with left fusiform gyrus,temporal cortex,hippocampus(HIPP)/amygdala,temporal pole,and right INS,superior occipital gyrus,and bilateral precuneus,superior parietal lobule(SPL),and decreased rsFC with left postcentral/precentral gyrus(PoG/PrG),supplementary motor area(SMA)and right cerebellum.32 FD patients which were then re-divided into the actual deqi group(n=16)and actual without deqi group(n=16).The decrease of the NDI symptom score(pre-pos)in the actual deqi group was significantly greater than that in the actual without deqi group(P<0.05).Among the two groups,the actual deqi group showed increased ACC subregions rsFC with right SMA and bilateral PrG/PoG,and decreased rsFC with right precuneus,middle occipi
文摘任意波形发生器(又叫函数发生器)作为一种通用的信号源,在物理、电子、计算机等领域有着广泛的应用.本文提出了一种不依赖PC机总线的、完全独立的、可用于低场磁共振成像的多用途任意波形发生器(Arbitrary Wave form Generator,AWG)设计方案,围绕着这种方案,研制了80MHz通用磁共振任意波形发生器.并提供了实际测试数据和成像实验结果,对研制情况和实验结果进行了总结和讨论.
文摘国际医学MR学会（International Society for Magnetic Resonance in Medicine, ISMRM）创立于1994年，是全球规模最大和最具影响力的医学MR学会。第23届ISMRM年会于2015年5月30日至6月5日在加拿大多伦多召开。本次大会有来自全球70多个国家的6000多名研究者参会，共收录口头报告1074篇，传统墙报1803篇，电子墙报1852篇，内容涵盖MR在医学、物理、生物学等方面的基础与临床研究。来自中国的研究中，南方医科大学和香港大学各一项研究荣获本次大会的“Summa Cum Laude”优秀论文奖，另外来自国内多家单位的13项研究荣获本次大会的“Manga Cure Laude”优秀论文奖。
