Rat brain gliomas were induced by transplacental and subcutaneous administration of synthesized Nethyl-N-nitrosourea(EVU, 60 mg/kg body weight) in the late gestational and 3-day Wistar rats respectively, observed unti...Rat brain gliomas were induced by transplacental and subcutaneous administration of synthesized Nethyl-N-nitrosourea(EVU, 60 mg/kg body weight) in the late gestational and 3-day Wistar rats respectively, observed until the end of 12th month after administration.The incidences of tumor formation were 73. 2% and 68.3% (those of gliomas were 65. 9% and 63. 4%) respectively. Histologically, the main types were mixed oligodendro-astrocytomas and oligodendrogliomas, with the characteristics of being microfocal, multifocal and mixed, in presence with focal and/or diffuse proliferation of glial cells. The results showed that these glioma models induced by the synthesized ENU were successful and stable, serving a fine approach to further study of the initiation,growth and differentiation of gliomas. The significance of proliferation of glioblasts in the oncogenesis of ENU-induced gliomas was discussed in this report.展开更多
文摘Rat brain gliomas were induced by transplacental and subcutaneous administration of synthesized Nethyl-N-nitrosourea(EVU, 60 mg/kg body weight) in the late gestational and 3-day Wistar rats respectively, observed until the end of 12th month after administration.The incidences of tumor formation were 73. 2% and 68.3% (those of gliomas were 65. 9% and 63. 4%) respectively. Histologically, the main types were mixed oligodendro-astrocytomas and oligodendrogliomas, with the characteristics of being microfocal, multifocal and mixed, in presence with focal and/or diffuse proliferation of glial cells. The results showed that these glioma models induced by the synthesized ENU were successful and stable, serving a fine approach to further study of the initiation,growth and differentiation of gliomas. The significance of proliferation of glioblasts in the oncogenesis of ENU-induced gliomas was discussed in this report.
