目的分析血清降钙素原（procalcitonin,PCT）、C-反应蛋白（C-reactive protein,CRP）和白细胞介素6（interleukin 6,IL-6）联合检测对脓毒症预后评估的临床价值。方法回顾性收集2005年1月—2015年1月本院收治的162例脓毒症患者。根据...目的分析血清降钙素原（procalcitonin,PCT）、C-反应蛋白（C-reactive protein,CRP）和白细胞介素6（interleukin 6,IL-6）联合检测对脓毒症预后评估的临床价值。方法回顾性收集2005年1月—2015年1月本院收治的162例脓毒症患者。根据患者入院后28 d转归分为生存组（83例）和死亡组（79例）。比较两组间PCT、CRP、IL-6、序贯器官衰竭评分（sequential organ failure assessment,SOFA）、急性生理学与慢性健康状况评分Ⅱ（acute physiology and chronic health evaluationⅡ,APACHEⅡ）和急诊脓毒症死亡风险评分（mortality in emergency department sepsis,MEDS）差异,并比较PCT、CRP和IL-6评估预后的能力。结果 162例年龄19~83（57.06±15.37）岁,男102例（63.0%）,女60例（37.0%）。死亡组并发心血管疾病、中枢神经疾病和消化道疾病例数高于生存组（P〈0.05）。死亡组的PCT、CRP、IL-6、SOFA、APACHEⅡ和MEDS评分数值高于生存组（P〈0.05）。将PCT、CRP和IL-6联合检测时用于判断脓毒症预后的ROC曲线下面积（area under ROC curve,AUC）为0.955,大于PCT（AUC=0.941）、CRP（AUC=0.780）和IL-6（AUC=0.884）单独检测时的面积。联合检测的敏感度（86.5%）、特异度（96.4%）、阳性预测值（95.6%）和阴性预测值（85.1%）均大于单独检测PCT（敏感度77.2%,特异度95.2%,阳性预测值93.8%,阴性预测值81.4%）、CRP（敏感度72.2%,特异度83.1%,阳性预测值80.2%,阴性预测值75.8%）和IL-6（敏感度86.1%,特异度72.3%,阳性预测值74.7%,阴性预测值84.5%）。结论 PCT、CRP和IL-6联合检测较单独检测能更有效地评估脓毒症预后。展开更多
Objective: To observe the effects of Xuebijing Injection (血必净注射液) in patients with severe pneumonia, and to explore the mechanism. Methods: Eighty cases of severe pneumonia are randomly assigned to the Xuebijing...Objective: To observe the effects of Xuebijing Injection (血必净注射液) in patients with severe pneumonia, and to explore the mechanism. Methods: Eighty cases of severe pneumonia are randomly assigned to the Xuebijing treatment (forty cases) and the control group (forty cases), with the same routine therapy provided in both groups. Clinical effective rates, inflammatory factors and organ function were observed in both groups. Results: The effective rate was higher in Xuebijing group than that of the control group (80.0% vs. 67.5%, P<0.05). As compared with the control group, the LDH, α1-AG, α1-AT levels and the peak body temperature decreased markedly with the Xuebijing treatment going, and the secretion of TNF-α, IL-6, IL-8 was suppressed in Xuebijing group; but no significant difference was found in leptin level. Conclusion: Xuebijing Injection may show a protective effect in patients with severe pneumonia. The mechanism is possibly with the decreased secretion of TNF-α, IL-6, and IL-8.展开更多
文摘目的分析血清降钙素原（procalcitonin,PCT）、C-反应蛋白（C-reactive protein,CRP）和白细胞介素6（interleukin 6,IL-6）联合检测对脓毒症预后评估的临床价值。方法回顾性收集2005年1月—2015年1月本院收治的162例脓毒症患者。根据患者入院后28 d转归分为生存组（83例）和死亡组（79例）。比较两组间PCT、CRP、IL-6、序贯器官衰竭评分（sequential organ failure assessment,SOFA）、急性生理学与慢性健康状况评分Ⅱ（acute physiology and chronic health evaluationⅡ,APACHEⅡ）和急诊脓毒症死亡风险评分（mortality in emergency department sepsis,MEDS）差异,并比较PCT、CRP和IL-6评估预后的能力。结果 162例年龄19~83（57.06±15.37）岁,男102例（63.0%）,女60例（37.0%）。死亡组并发心血管疾病、中枢神经疾病和消化道疾病例数高于生存组（P〈0.05）。死亡组的PCT、CRP、IL-6、SOFA、APACHEⅡ和MEDS评分数值高于生存组（P〈0.05）。将PCT、CRP和IL-6联合检测时用于判断脓毒症预后的ROC曲线下面积（area under ROC curve,AUC）为0.955,大于PCT（AUC=0.941）、CRP（AUC=0.780）和IL-6（AUC=0.884）单独检测时的面积。联合检测的敏感度（86.5%）、特异度（96.4%）、阳性预测值（95.6%）和阴性预测值（85.1%）均大于单独检测PCT（敏感度77.2%,特异度95.2%,阳性预测值93.8%,阴性预测值81.4%）、CRP（敏感度72.2%,特异度83.1%,阳性预测值80.2%,阴性预测值75.8%）和IL-6（敏感度86.1%,特异度72.3%,阳性预测值74.7%,阴性预测值84.5%）。结论 PCT、CRP和IL-6联合检测较单独检测能更有效地评估脓毒症预后。
文摘Objective: To observe the effects of Xuebijing Injection (血必净注射液) in patients with severe pneumonia, and to explore the mechanism. Methods: Eighty cases of severe pneumonia are randomly assigned to the Xuebijing treatment (forty cases) and the control group (forty cases), with the same routine therapy provided in both groups. Clinical effective rates, inflammatory factors and organ function were observed in both groups. Results: The effective rate was higher in Xuebijing group than that of the control group (80.0% vs. 67.5%, P<0.05). As compared with the control group, the LDH, α1-AG, α1-AT levels and the peak body temperature decreased markedly with the Xuebijing treatment going, and the secretion of TNF-α, IL-6, IL-8 was suppressed in Xuebijing group; but no significant difference was found in leptin level. Conclusion: Xuebijing Injection may show a protective effect in patients with severe pneumonia. The mechanism is possibly with the decreased secretion of TNF-α, IL-6, and IL-8.
