Effects of Lycium barbarum polysaccharide(LBP),Astragalus polysaccharide (APS),polysaccharide of Acanthopanax senticosus(PAS)and polysaccharide of bacterial lipopolysaccharide(PS)on the induction of lymphokine-activat...Effects of Lycium barbarum polysaccharide(LBP),Astragalus polysaccharide (APS),polysaccharide of Acanthopanax senticosus(PAS)and polysaccharide of bacterial lipopolysaccharide(PS)on the induction of lymphokine-activated killer(LAK)cells from C57BL/6 murine splenocytes were studied using [^(125)I]UdR release assay.The four polysaccharides alone were shown to induce no cytotoxicity.When combined with human recombination interleukin-2(rlL-2),they augmented LAK cell activities in a dose-dependent manner,most markedly at 0.01～0.1 mg·ml^(-1)for LBP,0.01 mg·ml^(-1) for APS and PAS,and 0.01 μg·ml^(-1) for PS.They increased LAK cell activity in a short range of rIL-2 concentrations(250～1000U·ml^(-1)).They were shown to inhibit LAK cell activity when used beyond the suitable dosage.展开更多
文摘Effects of Lycium barbarum polysaccharide(LBP),Astragalus polysaccharide (APS),polysaccharide of Acanthopanax senticosus(PAS)and polysaccharide of bacterial lipopolysaccharide(PS)on the induction of lymphokine-activated killer(LAK)cells from C57BL/6 murine splenocytes were studied using [^(125)I]UdR release assay.The four polysaccharides alone were shown to induce no cytotoxicity.When combined with human recombination interleukin-2(rlL-2),they augmented LAK cell activities in a dose-dependent manner,most markedly at 0.01～0.1 mg·ml^(-1)for LBP,0.01 mg·ml^(-1) for APS and PAS,and 0.01 μg·ml^(-1) for PS.They increased LAK cell activity in a short range of rIL-2 concentrations(250～1000U·ml^(-1)).They were shown to inhibit LAK cell activity when used beyond the suitable dosage.
