Snake venom disintegrins,through their inhibition of integrin-related binding,effectively impede both cell-cell and cell-matrix interactions as well as signal transduction pathways,rendering them promising candidates ...Snake venom disintegrins,through their inhibition of integrin-related binding,effectively impede both cell-cell and cell-matrix interactions as well as signal transduction pathways,rendering them promising candidates for lead therapeutics across a spectrum of diseases.This study aimed to conduct a comprehensive bibliometric analysis,elucidating recent trends in disintegrin research.Using relevant keywords,we meticulously explored the Web of Science Core Collection(WOSCC)database.Employing CiteSpace and VOSviewer,we conducted an exhaustive analysis,encompassing 142 documents published between 2009 and 2023.These publications,dispersed across 74 journals,involved 670 authors representing 207 institutes spanning 42 countries.Notably,the United States contributed the highest number of records,with Texas A&M University emerging as the most prolific institution.Within this landscape,Elda E.Sanchez emerged as the foremost author,and Toxicon emerged as the predominant journal.Keyword analysis underscored prevailing research foci,with an emphasis on expression,in vitro experimentation,and ASP-containing peptides.This study presented a comprehensive overview of disintegrin research globally,spanning the period from 2009 to 2023,and held potential utility in guiding future research endeavors.By identifying current research hotspots,our findings offered invaluable insights to shape forthcoming investigations in this dynamic field.展开更多
三阴性乳腺癌(Triple-negative breast cancer,TNBC)是世界上最常见的恶性肿瘤之一,具有独特的病理学特征及高度异质性,较其他乳腺癌亚型易发生转移、恶性程度高、预后差等。抗体偶联药物(Antibody-drug conjugates,ADCs)是一类由单克...三阴性乳腺癌(Triple-negative breast cancer,TNBC)是世界上最常见的恶性肿瘤之一,具有独特的病理学特征及高度异质性,较其他乳腺癌亚型易发生转移、恶性程度高、预后差等。抗体偶联药物(Antibody-drug conjugates,ADCs)是一类由单克隆抗体及小分子细胞毒性载体通过连接子偶联而成的有潜力的新型肿瘤靶向药物,直接将细胞毒性物质递送到靶细胞上,在TNBC的临床研究中具有广阔的应用前景。目前,已有多个ADCs被应用于治疗TNBC,本文重点对现阶段ADCs在TNBC中的研究进展进行综述。展开更多
基金Startup Fund for Scientific Research,Fujian Medical University(Grant No.2022QH1216)。
文摘Snake venom disintegrins,through their inhibition of integrin-related binding,effectively impede both cell-cell and cell-matrix interactions as well as signal transduction pathways,rendering them promising candidates for lead therapeutics across a spectrum of diseases.This study aimed to conduct a comprehensive bibliometric analysis,elucidating recent trends in disintegrin research.Using relevant keywords,we meticulously explored the Web of Science Core Collection(WOSCC)database.Employing CiteSpace and VOSviewer,we conducted an exhaustive analysis,encompassing 142 documents published between 2009 and 2023.These publications,dispersed across 74 journals,involved 670 authors representing 207 institutes spanning 42 countries.Notably,the United States contributed the highest number of records,with Texas A&M University emerging as the most prolific institution.Within this landscape,Elda E.Sanchez emerged as the foremost author,and Toxicon emerged as the predominant journal.Keyword analysis underscored prevailing research foci,with an emphasis on expression,in vitro experimentation,and ASP-containing peptides.This study presented a comprehensive overview of disintegrin research globally,spanning the period from 2009 to 2023,and held potential utility in guiding future research endeavors.By identifying current research hotspots,our findings offered invaluable insights to shape forthcoming investigations in this dynamic field.
文摘三阴性乳腺癌(Triple-negative breast cancer,TNBC)是世界上最常见的恶性肿瘤之一,具有独特的病理学特征及高度异质性,较其他乳腺癌亚型易发生转移、恶性程度高、预后差等。抗体偶联药物(Antibody-drug conjugates,ADCs)是一类由单克隆抗体及小分子细胞毒性载体通过连接子偶联而成的有潜力的新型肿瘤靶向药物,直接将细胞毒性物质递送到靶细胞上,在TNBC的临床研究中具有广阔的应用前景。目前,已有多个ADCs被应用于治疗TNBC,本文重点对现阶段ADCs在TNBC中的研究进展进行综述。
