Background:The aim of the study was to explore the regularity of acupoints combination in the treatment of functional dyspepsia(FD)by means of data mining technology.Methods:We conducted a systematic search of nine da...Background:The aim of the study was to explore the regularity of acupoints combination in the treatment of functional dyspepsia(FD)by means of data mining technology.Methods:We conducted a systematic search of nine databases from their inception to December 2022 to identify eligible randomized controlled trials(RCTs).The acupoints prescriptions in the treatment of FD were extracted and analyzed based on association rule mining and network analysis.Furthermore,the acupoints prescribed for irritability symptom of FD were quantified by forward inference,reverse inference and Bayes factor(BF)correction.Results:A total of 45 RCTs on 30 acupoints were included,involving 172 times the total application frequency.Analysis of acupoints prescriptions covered 29 meridian acupoints and one extra-ordinary point,disturbing in 10 meridians.The top three acupoints in application frequency were Zusanli(ST36,19.77%),Neiguan(PC6,16.86%),Zhongwan(CV12,12.21%).The most involved meridian was the foot yangming stomach meridian(34 times).The most frequently used acupoints combinations were PC6 and ST36.The core prescriptions were ST36,PC6,Tianshu(ST25),CV12.The specificities of acupoints selection for FD with dysphoria as follows:using the forward inference,PC6,Taichong(LR3),Qimen(LR14),CV12,Danzhong(CV17),ST25,ST36 were selected.Using the reverse inference and BF correction,PC6,CV12,CV17,Sanyinjiao(SP6),ST25,ST36 were selected.展开更多
调节性T细胞(regulatory T cell,Treg)在抑制免疫方面具有独特的作用,是宿主维持机体免疫稳态的主要细胞。近年来研究发现,Treg细胞可继续分化为多种亚型,在不同的组织环境和免疫应答中会适应性表现辅助性T细胞(helper T lymphocytes,Th...调节性T细胞(regulatory T cell,Treg)在抑制免疫方面具有独特的作用,是宿主维持机体免疫稳态的主要细胞。近年来研究发现,Treg细胞可继续分化为多种亚型,在不同的组织环境和免疫应答中会适应性表现辅助性T细胞(helper T lymphocytes,Th)的特殊表型,表达与Th相关的转录因子,发挥独特的功能特性。肌腱膜纤维肉瘤原癌基因转录因子(c-musculoaponeurotic-fibrosarcoma,c-Maf)在Treg细胞的适应性分化过程有着重要作用。本文就c-Maf在Treg细胞中的特化作用做一简要综述,其中主要涉及表达核激素受体视黄酸受体相关孤儿受体γt(receptor-related orphan receptorγt,RORγt)Treg细胞和表达B细胞淋巴瘤蛋白6(B-cell lymphoma 6,Bcl-6)的滤泡调节性T细胞(follicular regulatory T cell,Tfr)的形成,以进一步讨论Treg细胞介导的免疫机制。展开更多
基金Supported by Zhejiang Provincial Natural Science Fund of China:LY20H270006,LY19H270003Zhejiang Medical and Health Science and Technology Program:2021RC098National Natural Science Fund of China:81873360。
文摘Background:The aim of the study was to explore the regularity of acupoints combination in the treatment of functional dyspepsia(FD)by means of data mining technology.Methods:We conducted a systematic search of nine databases from their inception to December 2022 to identify eligible randomized controlled trials(RCTs).The acupoints prescriptions in the treatment of FD were extracted and analyzed based on association rule mining and network analysis.Furthermore,the acupoints prescribed for irritability symptom of FD were quantified by forward inference,reverse inference and Bayes factor(BF)correction.Results:A total of 45 RCTs on 30 acupoints were included,involving 172 times the total application frequency.Analysis of acupoints prescriptions covered 29 meridian acupoints and one extra-ordinary point,disturbing in 10 meridians.The top three acupoints in application frequency were Zusanli(ST36,19.77%),Neiguan(PC6,16.86%),Zhongwan(CV12,12.21%).The most involved meridian was the foot yangming stomach meridian(34 times).The most frequently used acupoints combinations were PC6 and ST36.The core prescriptions were ST36,PC6,Tianshu(ST25),CV12.The specificities of acupoints selection for FD with dysphoria as follows:using the forward inference,PC6,Taichong(LR3),Qimen(LR14),CV12,Danzhong(CV17),ST25,ST36 were selected.Using the reverse inference and BF correction,PC6,CV12,CV17,Sanyinjiao(SP6),ST25,ST36 were selected.
文摘调节性T细胞(regulatory T cell,Treg)在抑制免疫方面具有独特的作用,是宿主维持机体免疫稳态的主要细胞。近年来研究发现,Treg细胞可继续分化为多种亚型,在不同的组织环境和免疫应答中会适应性表现辅助性T细胞(helper T lymphocytes,Th)的特殊表型,表达与Th相关的转录因子,发挥独特的功能特性。肌腱膜纤维肉瘤原癌基因转录因子(c-musculoaponeurotic-fibrosarcoma,c-Maf)在Treg细胞的适应性分化过程有着重要作用。本文就c-Maf在Treg细胞中的特化作用做一简要综述,其中主要涉及表达核激素受体视黄酸受体相关孤儿受体γt(receptor-related orphan receptorγt,RORγt)Treg细胞和表达B细胞淋巴瘤蛋白6(B-cell lymphoma 6,Bcl-6)的滤泡调节性T细胞(follicular regulatory T cell,Tfr)的形成,以进一步讨论Treg细胞介导的免疫机制。
