Aquaporins are small integral membrane proteins that selectively transport water and some small solutes in mammals, plants and lower organisms. Continued studies of the aquaporins are providing detailed tissue localiz...Aquaporins are small integral membrane proteins that selectively transport water and some small solutes in mammals, plants and lower organisms. Continued studies of the aquaporins are providing detailed tissue localization and the important physiological roles of aquaporins in urinary, respiratory, digestive and nervous systems. Based on the importance of aquaporin studies in the field of structural chemistry in biomembranes, American scientist Peter Agre won the 2003 Chemistry Nobel Prize for the discovery of water channels.展开更多
Background The incidence of prostate carcinoma (Pca) has been increasing in China. We detected Pca in elderly men in Changchun,north China and the significance of prostate specific antigen (PSA) in mass screening an...Background The incidence of prostate carcinoma (Pca) has been increasing in China. We detected Pca in elderly men in Changchun,north China and the significance of prostate specific antigen (PSA) in mass screening and clinical staging of Pca. Methods Serum PSA from 12 027 men over 50 years old from Changchun was analyzed. In case of serum PSA greater than 4.0 ng/ml,the patient was suspected of potentially suffering from Pca,and transrectal six-point puncture prostate biopsies were performed under ultrasound guidance. Pathological examinations were performed on the biopsy tissue,and ABCD and TNM clinical stagings were used in accordance with international standards. Correlations between serum PSA level and clinical stage were analyzed. Results PSA was greater than 4.0 ng/ml in 813 patients (6.8% of the 12 027 men). Transrectal six-point prostate puncture biopsies guided by ultrasound were performed in 273 patients (33.6% of the 813 patients who were tested positive in the initial mass screening). Of these 273 patients,69 cases of Pca (25.3% of 273) were confirmed by biopsy in the second screening,with an overall detection rate for Pca of 0.57% (69/12 027). The total number of patients in stages A,B,T1,or T2 was 57.9%,and over 20% of them suffered from late stage Pca with lymph node and bone metastasis. An obvious positive correlation was observed between ABCD staging,TNM staging,and serum PSA level. Conclusions Serum PSA level is not only the golden standard for mass screening of Pca,but also the predictor for clinical stage of Pca. PSA testing revealed asymptomatic Pca cases in early,middle,and later stages in the elderly,suggesting that mass screening is of paramount importance.展开更多
文摘Aquaporins are small integral membrane proteins that selectively transport water and some small solutes in mammals, plants and lower organisms. Continued studies of the aquaporins are providing detailed tissue localization and the important physiological roles of aquaporins in urinary, respiratory, digestive and nervous systems. Based on the importance of aquaporin studies in the field of structural chemistry in biomembranes, American scientist Peter Agre won the 2003 Chemistry Nobel Prize for the discovery of water channels.
基金ThisstudywasaprojectoftheJapan ChinaInternationalSpecialTechnicalCooperation (No 5 9) ,andwassupportedbytheJapanInternationalCooperationAgency (JICA)
文摘Background The incidence of prostate carcinoma (Pca) has been increasing in China. We detected Pca in elderly men in Changchun,north China and the significance of prostate specific antigen (PSA) in mass screening and clinical staging of Pca. Methods Serum PSA from 12 027 men over 50 years old from Changchun was analyzed. In case of serum PSA greater than 4.0 ng/ml,the patient was suspected of potentially suffering from Pca,and transrectal six-point puncture prostate biopsies were performed under ultrasound guidance. Pathological examinations were performed on the biopsy tissue,and ABCD and TNM clinical stagings were used in accordance with international standards. Correlations between serum PSA level and clinical stage were analyzed. Results PSA was greater than 4.0 ng/ml in 813 patients (6.8% of the 12 027 men). Transrectal six-point prostate puncture biopsies guided by ultrasound were performed in 273 patients (33.6% of the 813 patients who were tested positive in the initial mass screening). Of these 273 patients,69 cases of Pca (25.3% of 273) were confirmed by biopsy in the second screening,with an overall detection rate for Pca of 0.57% (69/12 027). The total number of patients in stages A,B,T1,or T2 was 57.9%,and over 20% of them suffered from late stage Pca with lymph node and bone metastasis. An obvious positive correlation was observed between ABCD staging,TNM staging,and serum PSA level. Conclusions Serum PSA level is not only the golden standard for mass screening of Pca,but also the predictor for clinical stage of Pca. PSA testing revealed asymptomatic Pca cases in early,middle,and later stages in the elderly,suggesting that mass screening is of paramount importance.
