Lioresal [β-(4-chlorophenyl)-γ-aminobutyric acid] is a GABA-derivative, which not only inhibits the spinal monosynaptic and polysynaptic reflexes in cats, rats and frogs, but also markedly depresses the electrical a...Lioresal [β-(4-chlorophenyl)-γ-aminobutyric acid] is a GABA-derivative, which not only inhibits the spinal monosynaptic and polysynaptic reflexes in cats, rats and frogs, but also markedly depresses the electrical activity of some neurons of brain. Saito and Otsuka reported that Lioresal significantly depressed the action of Substance P (SP) on the excitatory action of rat spinal motoneurons, whereas it exerted little effect on the response to glutamate. Therefore, these authors suggest that Lioresal might be an antagonist of SP. But this hypothesis has not yet been generally accepted.展开更多
The correlation or serum estradiol concentrstion and uterine estrogen receptor (ER) gene expression (ERn and ERc quantitated by Dextrsn Coat Charcoal assay and ER mRNA by Northern blotting) was studied during the rat ...The correlation or serum estradiol concentrstion and uterine estrogen receptor (ER) gene expression (ERn and ERc quantitated by Dextrsn Coat Charcoal assay and ER mRNA by Northern blotting) was studied during the rat estrous cycle and early Pregnant stage (dl-d10). The ER gone expression was up - regulated by estrogen and the levels of ER mRNA synchronized with the changes of ER protein, suggesting that estrogen influenced the trsnscriPtional step of the ER gene. Post-coitum ER expression increased with the serum estrsdiol progressively, reached a peak on d4-ds (Just before implantation), but drastically dropped to the nadir on d6-d7 (during implantation) and then recovered. It was of interest to discover that ER mRNA level in the nonimplantstion sites (NIS) of uterus was much higher than that in the implantstion sites (IS).展开更多
文摘Lioresal [β-(4-chlorophenyl)-γ-aminobutyric acid] is a GABA-derivative, which not only inhibits the spinal monosynaptic and polysynaptic reflexes in cats, rats and frogs, but also markedly depresses the electrical activity of some neurons of brain. Saito and Otsuka reported that Lioresal significantly depressed the action of Substance P (SP) on the excitatory action of rat spinal motoneurons, whereas it exerted little effect on the response to glutamate. Therefore, these authors suggest that Lioresal might be an antagonist of SP. But this hypothesis has not yet been generally accepted.
文摘The correlation or serum estradiol concentrstion and uterine estrogen receptor (ER) gene expression (ERn and ERc quantitated by Dextrsn Coat Charcoal assay and ER mRNA by Northern blotting) was studied during the rat estrous cycle and early Pregnant stage (dl-d10). The ER gone expression was up - regulated by estrogen and the levels of ER mRNA synchronized with the changes of ER protein, suggesting that estrogen influenced the trsnscriPtional step of the ER gene. Post-coitum ER expression increased with the serum estrsdiol progressively, reached a peak on d4-ds (Just before implantation), but drastically dropped to the nadir on d6-d7 (during implantation) and then recovered. It was of interest to discover that ER mRNA level in the nonimplantstion sites (NIS) of uterus was much higher than that in the implantstion sites (IS).
