病人健康问卷（Patient Health Questionnaire-9,PHQ-9）是一个简便、有效的抑郁障碍自评量表,在抑郁症诊断的辅助和症状严重程度评估方面,均具有良好的信度和效度.在基于评估的治疗策略中,PHQ-9可以作为制订治疗方案的参考,以及治疗过...病人健康问卷（Patient Health Questionnaire-9,PHQ-9）是一个简便、有效的抑郁障碍自评量表,在抑郁症诊断的辅助和症状严重程度评估方面,均具有良好的信度和效度.在基于评估的治疗策略中,PHQ-9可以作为制订治疗方案的参考,以及治疗过程中对疗效的评估工具.PHQ-9的衍生版本PHQ-8,PHQ-2和他评量表PHQ-9-OV,针对不同研究对象,有着相应的临床应用效果.现就PHQ-9在临床的应用及优势进行论述.展开更多
Background An important aspect of Alzheimer’s disease (AD) is loss or impairment of cholinergic neurons It is controversial whether there is a similar cholinergic impairment and cerebral deficit of acetylcholine (...Background An important aspect of Alzheimer’s disease (AD) is loss or impairment of cholinergic neurons It is controversial whether there is a similar cholinergic impairment and cerebral deficit of acetylcholine (ACh) in the case of vascular dementia (VD) The purpose of this study was to explore the levels of ACh and choline (Ch) in the cerebrospinal fluid (CSF) of patients with AD and VD, and their possible relationship with cognitive impairment KH*2/5DMethods Twenty-two AD patients, twenty-two VD patients, and twenty normal controls were recruited and scored with a Mini-Mental State Examination (MMSE) CSF concentrations of ACh and Ch were measured using high-performance liquid chromatography with an electrochemical detector (HPLC-ECD) and the results were then compared to cognitive status Results ACh concentrations in CSF of AD patients [(10 7±5 1) nmol/L] and VD patients [(16 8±7 4) nmol/L] were both significantly lower than in controls [(34 5±9 0) nmol/L, t =10 67, P <0 001; t =6 91, P <0 001] Both results correlated positively with MMSE scores ( r s =0 88 and r s =0 85, respectively, P <0 01) The CSF concentration of Ch was significantly higher in VD patients [(887 4±187 4) nmol/L] compared to AD patients [(627 6±145 1) nmol/L, t =6 4, P <0 001] and controls [(716 0±159 4) nmol/L, t =4 2, P =0 002] CSF Ch concentration showed no difference between AD patients and normal controls, nor did it correlate with MMSE score in any of the three groups Conclusions The positive correlation between ACh deficit and cognitive impairment suggests that ACh is an important neurotransmitter for memory The similar decrease in ACh concentration in AD and VD patients may imply a similar pathogenesis for the process of cognitive impairment involved in these two disorders The elevated CSF levels of Ch in VD patients compared to AD patients may be useful diagnostically Cholinesterase inhibitors may be helpful not only for AD patients, but als展开更多
文摘病人健康问卷（Patient Health Questionnaire-9,PHQ-9）是一个简便、有效的抑郁障碍自评量表,在抑郁症诊断的辅助和症状严重程度评估方面,均具有良好的信度和效度.在基于评估的治疗策略中,PHQ-9可以作为制订治疗方案的参考,以及治疗过程中对疗效的评估工具.PHQ-9的衍生版本PHQ-8,PHQ-2和他评量表PHQ-9-OV,针对不同研究对象,有着相应的临床应用效果.现就PHQ-9在临床的应用及优势进行论述.
基金ThisworkwassupportedbyBeijingMedicalDevelopmentFunds (No .ZD199812 )
文摘Background An important aspect of Alzheimer’s disease (AD) is loss or impairment of cholinergic neurons It is controversial whether there is a similar cholinergic impairment and cerebral deficit of acetylcholine (ACh) in the case of vascular dementia (VD) The purpose of this study was to explore the levels of ACh and choline (Ch) in the cerebrospinal fluid (CSF) of patients with AD and VD, and their possible relationship with cognitive impairment KH*2/5DMethods Twenty-two AD patients, twenty-two VD patients, and twenty normal controls were recruited and scored with a Mini-Mental State Examination (MMSE) CSF concentrations of ACh and Ch were measured using high-performance liquid chromatography with an electrochemical detector (HPLC-ECD) and the results were then compared to cognitive status Results ACh concentrations in CSF of AD patients [(10 7±5 1) nmol/L] and VD patients [(16 8±7 4) nmol/L] were both significantly lower than in controls [(34 5±9 0) nmol/L, t =10 67, P <0 001; t =6 91, P <0 001] Both results correlated positively with MMSE scores ( r s =0 88 and r s =0 85, respectively, P <0 01) The CSF concentration of Ch was significantly higher in VD patients [(887 4±187 4) nmol/L] compared to AD patients [(627 6±145 1) nmol/L, t =6 4, P <0 001] and controls [(716 0±159 4) nmol/L, t =4 2, P =0 002] CSF Ch concentration showed no difference between AD patients and normal controls, nor did it correlate with MMSE score in any of the three groups Conclusions The positive correlation between ACh deficit and cognitive impairment suggests that ACh is an important neurotransmitter for memory The similar decrease in ACh concentration in AD and VD patients may imply a similar pathogenesis for the process of cognitive impairment involved in these two disorders The elevated CSF levels of Ch in VD patients compared to AD patients may be useful diagnostically Cholinesterase inhibitors may be helpful not only for AD patients, but als
