Topological materials have novel properties both in their bulk and boundaries,thereby attracting a wide interest in the theoretical and experimental communities.The recent development of the topological quantum chemis...Topological materials have novel properties both in their bulk and boundaries,thereby attracting a wide interest in the theoretical and experimental communities.The recent development of the topological quantum chemistry and symmetrybased indicator theory in this field has significantly simplified the procedure for determining the topological properties of nonmagnetic crystalline materials.Accordingly,a large number of new topological materials have been found by scanning large crystal databases.This study provides details on the algorithm used in the Catalogue of Topological Electronic Materials.Moreover,based on the algorithm,we develop an automatic package named SymTopo,which calculates the symmetry representations of any given nonmagnetic crystalline material and predicts its topological properties.This package may facilitate the discovery of more topological materials in the future.展开更多
目的:探讨皮质酮所致心肌肥大的机制。方法:(1)将H9c2 (大鼠心肌细胞)分为四组:正常对照组、皮质酮1组、皮质酮2组和皮质酮3组,分别在培养基中加入终浓度为0、100 nM、1μM和10μM的皮质酮培养3天,采用实时定量PCR技术检测糖皮质激素受...目的:探讨皮质酮所致心肌肥大的机制。方法:(1)将H9c2 (大鼠心肌细胞)分为四组:正常对照组、皮质酮1组、皮质酮2组和皮质酮3组,分别在培养基中加入终浓度为0、100 nM、1μM和10μM的皮质酮培养3天,采用实时定量PCR技术检测糖皮质激素受体(GR)、盐皮质激素受体(MR)和胰岛素样生长因子1受体(IGF-1R) mRNA的表达;(2)将H9c2细胞分为4组:米非司酮组、共处理组1、共处理组2和共处理组3,分别在培养基中加入终浓度为10μM米非司酮、10μM米非司酮和100 n M皮质酮、10μM米非司酮和1μM皮质酮、10μM米非司酮和10μM皮质酮培养3天,检测上述基因mRNA的表达。结果:与对照组相比,皮质酮组H9c2细胞GR、MR和IGF-1R m RNA水平显著升高且具有剂量依赖性;与米非司酮组相比,皮质酮与米非司酮共处理组GR、MR和IGF-1R不同程度被抑制。结论:"GR-IGF-1R"信号通路介导了皮质酮所致H9c2心肌细胞肥大。展开更多
基金Project supported by the Information Program of the Chinese Academy of Sciences(Grant No.XXH13506-202)
文摘Topological materials have novel properties both in their bulk and boundaries,thereby attracting a wide interest in the theoretical and experimental communities.The recent development of the topological quantum chemistry and symmetrybased indicator theory in this field has significantly simplified the procedure for determining the topological properties of nonmagnetic crystalline materials.Accordingly,a large number of new topological materials have been found by scanning large crystal databases.This study provides details on the algorithm used in the Catalogue of Topological Electronic Materials.Moreover,based on the algorithm,we develop an automatic package named SymTopo,which calculates the symmetry representations of any given nonmagnetic crystalline material and predicts its topological properties.This package may facilitate the discovery of more topological materials in the future.
文摘目的:探讨皮质酮所致心肌肥大的机制。方法:(1)将H9c2 (大鼠心肌细胞)分为四组:正常对照组、皮质酮1组、皮质酮2组和皮质酮3组,分别在培养基中加入终浓度为0、100 nM、1μM和10μM的皮质酮培养3天,采用实时定量PCR技术检测糖皮质激素受体(GR)、盐皮质激素受体(MR)和胰岛素样生长因子1受体(IGF-1R) mRNA的表达;(2)将H9c2细胞分为4组:米非司酮组、共处理组1、共处理组2和共处理组3,分别在培养基中加入终浓度为10μM米非司酮、10μM米非司酮和100 n M皮质酮、10μM米非司酮和1μM皮质酮、10μM米非司酮和10μM皮质酮培养3天,检测上述基因mRNA的表达。结果:与对照组相比,皮质酮组H9c2细胞GR、MR和IGF-1R m RNA水平显著升高且具有剂量依赖性;与米非司酮组相比,皮质酮与米非司酮共处理组GR、MR和IGF-1R不同程度被抑制。结论:"GR-IGF-1R"信号通路介导了皮质酮所致H9c2心肌细胞肥大。
