目的:研究前列腺癌骨转移患者血清中碱性磷酸酶(Alkaline phosphatase,ALP)、I型胶原羧基端肽(C-telopeptide of type I col,ICTP)、转化生长因子-β1(Transforming growth factor beta 1,TGF-β1)、血管内皮生长因子(Vascular endothel...目的:研究前列腺癌骨转移患者血清中碱性磷酸酶(Alkaline phosphatase,ALP)、I型胶原羧基端肽(C-telopeptide of type I col,ICTP)、转化生长因子-β1(Transforming growth factor beta 1,TGF-β1)、血管内皮生长因子(Vascular endothelial growth factor,VEGF)、白细胞介素-6(Interleukin-6,IL-6)的检测及其诊断分析,为临床上前列腺癌骨转移的诊治提供指导。方法:选取2015年5月~2019年5月内92例前列腺患者进行研究。将其依据PET-CT全身骨扫描的显示结果分为未发生骨转移的对照组(n=46)和发生骨转移的转移组(n=46)。采集所选患者的血清并用ELISA法检测其中ALP、ICTP、TGF-β1、VEGF、IL-6水平。观察两组患者各指标的水平差异及其与骨转移发生的相关性,由此分析ALP、ICTP、TGF-β1、VEGF、IL-6与前列腺癌骨转移的相关性。结果:转移组的ALP、ICTP、TGF-β1、VEGF、IL-6水平均明显高于对照组,差异有统计学意义;前列腺癌患者的血清ALP、ICTP、TGF-β1、VEGF、IL-6水平与骨转移的发生具有一定的相关性(r=0.4573、0.3992、0.2367、0.2588、0.3014)。将90U/L设为ALP的临界值,灵敏度、准确度和特异性分别为89.13%、66.30%、43.48%;将6μg/L设为ICTP的临界值,灵敏度、准确度和特异性分别为93.48%、86.96%、80.43%;将10ng/mL设为TGF-β1的临界值,灵敏度、准确度和特异性分别为86.96%、67.39%、47.83%;将8pmol/mL设为VEGF的临界值,灵敏度、准确度和特异性分别为84.78%、76.09%、67.39%;将15pg/mL设为IL-6的临界值,灵敏度、准确度和特异性分别为91.30%、66.30%、41.30%。结论:前列腺癌患者血清ALP、ICTP、TGF-β1、VEGF、IL-6水平均可作为诊断骨转移的可靠指标,并且其水平高低可以在一定程度上反映前列腺癌骨转移的进展程度,具有较高的临床应用价值。展开更多
本文旨在评估孕早期常规产前生化指标对妊娠期糖尿病GDM预测的应用和前景。本文系统地回顾了国内外文献,分析了空腹血糖、血脂、肝功能、肾功能、凝血功能及其他妊娠相关蛋白等在GDM预测中的作用和可靠性。分析发现空腹血糖、甘油三酯...本文旨在评估孕早期常规产前生化指标对妊娠期糖尿病GDM预测的应用和前景。本文系统地回顾了国内外文献,分析了空腹血糖、血脂、肝功能、肾功能、凝血功能及其他妊娠相关蛋白等在GDM预测中的作用和可靠性。分析发现空腹血糖、甘油三酯、低密度脂蛋白胆固醇、尿酸、肝酶(如GGT)、血小板指标(如MPV)以及孕早期PAPP-A等生化指标显示出了在GDM早期诊断中的潜在价值。这些指标的变化与GDM的发生密切相关,尤其是在孕早期的应用能够提供较高的敏感性和特异性。基于常规产前生化指标的综合应用能够有效提升对GDM的早期预测能力,有助于采取及早干预措施,改善孕妇和胎儿的健康结果。The aim of this paper is to assess the application and prospects of routine prenatal biochemical indicators in early pregnancy for the prediction of GDM in gestational diabetes mellitus. This paper systematically reviewed the national and international literature and analyzed the role and reliability of fasting blood glucose, lipids, liver function, renal function, coagulation function and other pregnancy-related proteins in the prediction of GDM. The analysis revealed that biochemical indicators such as fasting blood glucose, triglycerides, low-density lipoprotein cholesterol, uric acid, liver enzymes (e.g., GGT), platelet indexes (e.g., MPV), and PAPP-A in early pregnancy showed potential value in the early diagnosis of GDM. Changes in these indicators are closely related to the development of GDM, and their application especially in early pregnancy can provide high sensitivity and specificity. The comprehensive application based on routine prenatal biochemical indicators can effectively enhance the early prediction of GDM, which can help to take early interventions and improve the health outcomes of pregnant women and fetuses.展开更多
文摘目的:研究前列腺癌骨转移患者血清中碱性磷酸酶(Alkaline phosphatase,ALP)、I型胶原羧基端肽(C-telopeptide of type I col,ICTP)、转化生长因子-β1(Transforming growth factor beta 1,TGF-β1)、血管内皮生长因子(Vascular endothelial growth factor,VEGF)、白细胞介素-6(Interleukin-6,IL-6)的检测及其诊断分析,为临床上前列腺癌骨转移的诊治提供指导。方法:选取2015年5月~2019年5月内92例前列腺患者进行研究。将其依据PET-CT全身骨扫描的显示结果分为未发生骨转移的对照组(n=46)和发生骨转移的转移组(n=46)。采集所选患者的血清并用ELISA法检测其中ALP、ICTP、TGF-β1、VEGF、IL-6水平。观察两组患者各指标的水平差异及其与骨转移发生的相关性,由此分析ALP、ICTP、TGF-β1、VEGF、IL-6与前列腺癌骨转移的相关性。结果:转移组的ALP、ICTP、TGF-β1、VEGF、IL-6水平均明显高于对照组,差异有统计学意义;前列腺癌患者的血清ALP、ICTP、TGF-β1、VEGF、IL-6水平与骨转移的发生具有一定的相关性(r=0.4573、0.3992、0.2367、0.2588、0.3014)。将90U/L设为ALP的临界值,灵敏度、准确度和特异性分别为89.13%、66.30%、43.48%;将6μg/L设为ICTP的临界值,灵敏度、准确度和特异性分别为93.48%、86.96%、80.43%;将10ng/mL设为TGF-β1的临界值,灵敏度、准确度和特异性分别为86.96%、67.39%、47.83%;将8pmol/mL设为VEGF的临界值,灵敏度、准确度和特异性分别为84.78%、76.09%、67.39%;将15pg/mL设为IL-6的临界值,灵敏度、准确度和特异性分别为91.30%、66.30%、41.30%。结论:前列腺癌患者血清ALP、ICTP、TGF-β1、VEGF、IL-6水平均可作为诊断骨转移的可靠指标,并且其水平高低可以在一定程度上反映前列腺癌骨转移的进展程度,具有较高的临床应用价值。
文摘本文旨在评估孕早期常规产前生化指标对妊娠期糖尿病GDM预测的应用和前景。本文系统地回顾了国内外文献,分析了空腹血糖、血脂、肝功能、肾功能、凝血功能及其他妊娠相关蛋白等在GDM预测中的作用和可靠性。分析发现空腹血糖、甘油三酯、低密度脂蛋白胆固醇、尿酸、肝酶(如GGT)、血小板指标(如MPV)以及孕早期PAPP-A等生化指标显示出了在GDM早期诊断中的潜在价值。这些指标的变化与GDM的发生密切相关,尤其是在孕早期的应用能够提供较高的敏感性和特异性。基于常规产前生化指标的综合应用能够有效提升对GDM的早期预测能力,有助于采取及早干预措施,改善孕妇和胎儿的健康结果。The aim of this paper is to assess the application and prospects of routine prenatal biochemical indicators in early pregnancy for the prediction of GDM in gestational diabetes mellitus. This paper systematically reviewed the national and international literature and analyzed the role and reliability of fasting blood glucose, lipids, liver function, renal function, coagulation function and other pregnancy-related proteins in the prediction of GDM. The analysis revealed that biochemical indicators such as fasting blood glucose, triglycerides, low-density lipoprotein cholesterol, uric acid, liver enzymes (e.g., GGT), platelet indexes (e.g., MPV), and PAPP-A in early pregnancy showed potential value in the early diagnosis of GDM. Changes in these indicators are closely related to the development of GDM, and their application especially in early pregnancy can provide high sensitivity and specificity. The comprehensive application based on routine prenatal biochemical indicators can effectively enhance the early prediction of GDM, which can help to take early interventions and improve the health outcomes of pregnant women and fetuses.
