Diabetic nephropathy is one of the main causes of renal end-stage disease. The pathogenesis of diabetic nephropathy is complex. The current treatment is only for a particular cause without multi-target therapeutic dru...Diabetic nephropathy is one of the main causes of renal end-stage disease. The pathogenesis of diabetic nephropathy is complex. The current treatment is only for a particular cause without multi-target therapeutic drugs. Chinese medicine is a great treasure with multi-component complex drugs interacting with multiple targets and functions. This paper reviewed the protective effect of Chinese medicine for treating diabetic nephropathy in clinical studies, in vivo studies, and in vitro studies. The possible mechanisms, the major compounds and active crude drugs were also summarized. It was shown that Chinese medicine could not only relieve several symptoms and improve the quality of life, but also reduce the levels of proteinuria and kidney damage, and further improve renal function via multiple pathways based on the whole human system. Moreover, there were no reports of severe adverse reactions during the treatment.展开更多
From September 1987 to October 1988,30 cases of AIDS were treated on a trial ba-sis by TCM in an African country.Pres-ented in this paper is a clinical report of thecases treated.CLINICAL DATASource of CasesThe thirty...From September 1987 to October 1988,30 cases of AIDS were treated on a trial ba-sis by TCM in an African country.Pres-ented in this paper is a clinical report of thecases treated.CLINICAL DATASource of CasesThe thirty cases(20 in-patients and 10out-patients)treated were all diagnosed ashaving AIDS through clinical examinationsin a National Hospital of the country.展开更多
Objective:To observe the effect of Tangweikang Capsule(糖微康,TWK)on diabetic nephropathy(DN).Methods:The 119 DN patients were divided into two groups:the group of TWK treatment(n=78)and group of captopril(n=41)as the...Objective:To observe the effect of Tangweikang Capsule(糖微康,TWK)on diabetic nephropathy(DN).Methods:The 119 DN patients were divided into two groups:the group of TWK treatment(n=78)and group of captopril(n=41)as the control,the dose of which was 50 mg/d.The treatment lasted for 12 weeks.The changes of symptom score,urinary microprotein series,blood glucose,renal function,etc.were observed.Results:The total effective rate of the TWK group was 84.62%;and that of the control group was 70.73%,there was significant difference between the two groups(P<0.05).TWK treatment reduced the levels of blood glucose,blood lipid,serum creatinine,blood urea nitrogen,albumin,β2 microglobulin and Tamm Horsfall protein(P<0.05,P<0.01)in DN patients.The levels of triglyceride,angiotensinⅠ,angiotensinⅡ,atrial natriuretic polypeptide,prostaglandins,endothelin,typeⅣcollagen and total cholesterol decreased and the level of high density lipoprotein cholesterol increased in the serum of TWK treated DN patients(P<0.05,P<0.01).Conclusion:TWK exerted obviously ameliorating effect on renal function in DN patients.展开更多
基金Supported by the Major Discipline Clinical Research Project of the China Academy of Chinese Medical Sciences(No. CACMS05Y026)"Eleventh Five-Year"National Science and Technology Support Project of China(No.2006BAI04A04-2-2)National Specific Purpose of Major New Drugs"Great Platform of Research and Development of Integral Traditional Chinese Medicine"(No.2009ZX09301-005)
文摘Diabetic nephropathy is one of the main causes of renal end-stage disease. The pathogenesis of diabetic nephropathy is complex. The current treatment is only for a particular cause without multi-target therapeutic drugs. Chinese medicine is a great treasure with multi-component complex drugs interacting with multiple targets and functions. This paper reviewed the protective effect of Chinese medicine for treating diabetic nephropathy in clinical studies, in vivo studies, and in vitro studies. The possible mechanisms, the major compounds and active crude drugs were also summarized. It was shown that Chinese medicine could not only relieve several symptoms and improve the quality of life, but also reduce the levels of proteinuria and kidney damage, and further improve renal function via multiple pathways based on the whole human system. Moreover, there were no reports of severe adverse reactions during the treatment.
文摘From September 1987 to October 1988,30 cases of AIDS were treated on a trial ba-sis by TCM in an African country.Pres-ented in this paper is a clinical report of thecases treated.CLINICAL DATASource of CasesThe thirty cases(20 in-patients and 10out-patients)treated were all diagnosed ashaving AIDS through clinical examinationsin a National Hospital of the country.
基金The study belonged to State"Nine Five"Key Projects(No.9690607)
文摘Objective:To observe the effect of Tangweikang Capsule(糖微康,TWK)on diabetic nephropathy(DN).Methods:The 119 DN patients were divided into two groups:the group of TWK treatment(n=78)and group of captopril(n=41)as the control,the dose of which was 50 mg/d.The treatment lasted for 12 weeks.The changes of symptom score,urinary microprotein series,blood glucose,renal function,etc.were observed.Results:The total effective rate of the TWK group was 84.62%;and that of the control group was 70.73%,there was significant difference between the two groups(P<0.05).TWK treatment reduced the levels of blood glucose,blood lipid,serum creatinine,blood urea nitrogen,albumin,β2 microglobulin and Tamm Horsfall protein(P<0.05,P<0.01)in DN patients.The levels of triglyceride,angiotensinⅠ,angiotensinⅡ,atrial natriuretic polypeptide,prostaglandins,endothelin,typeⅣcollagen and total cholesterol decreased and the level of high density lipoprotein cholesterol increased in the serum of TWK treated DN patients(P<0.05,P<0.01).Conclusion:TWK exerted obviously ameliorating effect on renal function in DN patients.
