目的观察曲唑酮合并氟西汀治疗抑郁症的疗效及安全性。方法将60例符合入组标准的男性抑郁症患者随机分为研究组(30例)和对照组(30例),研究组予以氟西汀合并曲唑酮治疗,对照组单用氟西汀治疗,疗程8周。于入组时及治疗后1、2、4、8周采用H...目的观察曲唑酮合并氟西汀治疗抑郁症的疗效及安全性。方法将60例符合入组标准的男性抑郁症患者随机分为研究组(30例)和对照组(30例),研究组予以氟西汀合并曲唑酮治疗,对照组单用氟西汀治疗,疗程8周。于入组时及治疗后1、2、4、8周采用HAMD17项评分、HAMA评分、阿森氏失眠量表(AIS)、亚利桑那性生活问卷(Arizona Sexual Experience Scale,ASEX)、国际勃起功能指数问卷(IIEF-5)进行疗效评定,并进行不良反应评估。结果治疗第八周末两组HAMD总分、体重因子分、认知障碍因子分、迟缓因子分、睡眠障碍因子分的差异具有统计学意义(P<0.05或P<0.01),研究组均低于对照组。研究组AIS(P<0.05)、ASEX(P<0.01)、IIEF-5(P<0.01)评分优于对照组。治疗第八周末研究组临床痊愈26例(86.7%),对照组20例(66.7%),两组比较差异无统计学意义(χ2=3.354,P>0.05)。性功能改善情况:研究组痊愈8例(26.67%),显效16例(53.33%),有效4例(13.33%),无效2例(6.67%);对照组分别为2例(6.67%),13例(43.33%),6例(20%),9例(30%)。两组疗效差异具有统计学意义(χ2=8.765,P<0.05)。两组不良反应无显著差异,均为轻度。结论曲唑酮合并氟西汀对男性抑郁症患者抑郁、睡眠及性功能障碍有较好的疗效,安全性高。展开更多
A surface chemistry laboratory was established in the Department of chemistry. Currently, there arethree custom-designed ultra-high vacuum (UHV) systems equipped with a relatively wde range of sophisticated surface te...A surface chemistry laboratory was established in the Department of chemistry. Currently, there arethree custom-designed ultra-high vacuum (UHV) systems equipped with a relatively wde range of sophisticated surface techniques, such as, thermal desorption spectroscopy (TDS), low energy electron diffraction(LEED), high resolution electron energy loss spectroscopy (HREELS), X-ray photoelectron spectroscopy(XPS), ultra-violet photoelectron spectroscopy (UPS), Auger electron spectroscopy (AES), excimer UVlaser and 1000W 1000W lamp.A lamp.A UHV STM with variable temperature will be added soon, providing us with thecapability of resolving and manipulating the atomic arrangements on surfaces.The main objectives of the research programme are: (i) to understand the fundamental chemical and physical processes involved in gas-surface interactions; (ii) to provide the basic knowledge for developing advanced industrial technologies as well as synthesizing novel materials; and (iii) to train research scientists for localR&D industries. Our research work is focused on the studies of surface chemistry of excited adsorbates on metalsand semiconductors, and the interaetions of reactive atomic beams with surfaces.One aspect of our future development in the next five years is to establish an applied research programme inthe areas of thin films growth and in-situ studies of heterogeneous catalytic reactions under industrial conditions. The other is to probe the surface processes in real time frame by coupling the surface techniques with femto-second laser spectroscopies and to explore the surface chemistry and physics of size-selected metal clusters,initiating the concept of molccular surface chemistry.展开更多
文摘目的观察曲唑酮合并氟西汀治疗抑郁症的疗效及安全性。方法将60例符合入组标准的男性抑郁症患者随机分为研究组(30例)和对照组(30例),研究组予以氟西汀合并曲唑酮治疗,对照组单用氟西汀治疗,疗程8周。于入组时及治疗后1、2、4、8周采用HAMD17项评分、HAMA评分、阿森氏失眠量表(AIS)、亚利桑那性生活问卷(Arizona Sexual Experience Scale,ASEX)、国际勃起功能指数问卷(IIEF-5)进行疗效评定,并进行不良反应评估。结果治疗第八周末两组HAMD总分、体重因子分、认知障碍因子分、迟缓因子分、睡眠障碍因子分的差异具有统计学意义(P<0.05或P<0.01),研究组均低于对照组。研究组AIS(P<0.05)、ASEX(P<0.01)、IIEF-5(P<0.01)评分优于对照组。治疗第八周末研究组临床痊愈26例(86.7%),对照组20例(66.7%),两组比较差异无统计学意义(χ2=3.354,P>0.05)。性功能改善情况:研究组痊愈8例(26.67%),显效16例(53.33%),有效4例(13.33%),无效2例(6.67%);对照组分别为2例(6.67%),13例(43.33%),6例(20%),9例(30%)。两组疗效差异具有统计学意义(χ2=8.765,P<0.05)。两组不良反应无显著差异,均为轻度。结论曲唑酮合并氟西汀对男性抑郁症患者抑郁、睡眠及性功能障碍有较好的疗效,安全性高。
文摘A surface chemistry laboratory was established in the Department of chemistry. Currently, there arethree custom-designed ultra-high vacuum (UHV) systems equipped with a relatively wde range of sophisticated surface techniques, such as, thermal desorption spectroscopy (TDS), low energy electron diffraction(LEED), high resolution electron energy loss spectroscopy (HREELS), X-ray photoelectron spectroscopy(XPS), ultra-violet photoelectron spectroscopy (UPS), Auger electron spectroscopy (AES), excimer UVlaser and 1000W 1000W lamp.A lamp.A UHV STM with variable temperature will be added soon, providing us with thecapability of resolving and manipulating the atomic arrangements on surfaces.The main objectives of the research programme are: (i) to understand the fundamental chemical and physical processes involved in gas-surface interactions; (ii) to provide the basic knowledge for developing advanced industrial technologies as well as synthesizing novel materials; and (iii) to train research scientists for localR&D industries. Our research work is focused on the studies of surface chemistry of excited adsorbates on metalsand semiconductors, and the interaetions of reactive atomic beams with surfaces.One aspect of our future development in the next five years is to establish an applied research programme inthe areas of thin films growth and in-situ studies of heterogeneous catalytic reactions under industrial conditions. The other is to probe the surface processes in real time frame by coupling the surface techniques with femto-second laser spectroscopies and to explore the surface chemistry and physics of size-selected metal clusters,initiating the concept of molccular surface chemistry.
