X-ray Talbot-Lau interferometer has been used most widely to perform x-ray phase-contrast imaging with a con- ventional low-brilliance x-ray source, and it yields high-sensitivity phase and dark-field images of sample...X-ray Talbot-Lau interferometer has been used most widely to perform x-ray phase-contrast imaging with a con- ventional low-brilliance x-ray source, and it yields high-sensitivity phase and dark-field images of samples producing low absorption contrast, thus beating tremendous potential for future clinical diagnosis. In this work, by changing the accel- erating voltage of the x-ray tube from 35 kV to 45 kV, x-ray phase-contrast imaging of a test sample is performed at each integer value of the accelerating voltage to investigate the characteristic of an x-ray Talbot-Lau interferometer （located in the Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Japan） versus tube voltage. Ex- perimental results and data analysis show that within a range this x-ray Talbot-Lau interferometer is not sensitive to the accelerating voltage of the tube with a constant fringe visibility of ~ 44%. This x-ray Talbot-Lau interferometer research demonstrates the feasibility of a new dual energy phase-contrast x-ray imaging strategy and the possibility to collect a refraction spectrum.展开更多
We design a new kind of phase zone plates（PZPs） to improve the diffraction efficiency of soft x ray zone plates（ZPs）. The design replaces blank parts of PZPs with metals of negative phase shift at the working ener...We design a new kind of phase zone plates（PZPs） to improve the diffraction efficiency of soft x ray zone plates（ZPs）. The design replaces blank parts of PZPs with metals of negative phase shift at the working energy, which is called as the positive and negative PZPs（PNPZPs）. According to the calculation, PNPZPs have a higher maximum efficiency than conventional ZPs with the same zone width. With the help of a negative phase coefficient, it is much easier to achieve a π phase shift in one period, resulting in a smaller zone height. This design can help fabricate finer PZPs to achieve a better image resolution.展开更多
Grating-based x-ray phase contrast imaging has the potential to be applied in future medical applications as it is compatible with both laboratory and synchrotron source. However, information retrieval methods are imp...Grating-based x-ray phase contrast imaging has the potential to be applied in future medical applications as it is compatible with both laboratory and synchrotron source. However, information retrieval methods are important because acquisition speed, scanning mode, image quality, and radiation dose depend on them. Phase-stepping （PS） is a widely used method to retrieve information, while angular signal radiography （ASR） is a newly established method. In this manuscript, signal-to-noise ratios （SNRs） of ASR are compared with that of PS. Numerical experiments are performed to validate theoretical results. SNRs comparison shows that for refraction and scattering images ASR has higher SNR than PS method, while for absorption image both methods have same SNR. Therefore, our conclusions would have guideline in future preclinical and clinical applications.展开更多
基金Supported by National Research and Development Projects for Key Scientific Instruments(CZBZDYZ20140002)Fundamental Research Funds for the Central Universities(WK2310000065)~~
基金Project supported by the Major State Basic Research Development Program of China(Grant No.2012CB825800)the Science Fund for Creative Research Groups,China(Grant No.11321503)+1 种基金the National Natural Science Foundation of China(Grant Nos.11179004,10979055,11205189,and 11205157)the Japan–Asia Youth Exchange Program in Science(SAKURA Exchange Program in Science)Administered by the Japan Science and Technology Agency
文摘X-ray Talbot-Lau interferometer has been used most widely to perform x-ray phase-contrast imaging with a con- ventional low-brilliance x-ray source, and it yields high-sensitivity phase and dark-field images of samples producing low absorption contrast, thus beating tremendous potential for future clinical diagnosis. In this work, by changing the accel- erating voltage of the x-ray tube from 35 kV to 45 kV, x-ray phase-contrast imaging of a test sample is performed at each integer value of the accelerating voltage to investigate the characteristic of an x-ray Talbot-Lau interferometer （located in the Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Japan） versus tube voltage. Ex- perimental results and data analysis show that within a range this x-ray Talbot-Lau interferometer is not sensitive to the accelerating voltage of the tube with a constant fringe visibility of ~ 44%. This x-ray Talbot-Lau interferometer research demonstrates the feasibility of a new dual energy phase-contrast x-ray imaging strategy and the possibility to collect a refraction spectrum.
基金Supported by the Major State Basic Research Development Program(2012CB825800)the Science Fund for Creative Research Groups(11321503)+2 种基金the Knowledge Innovation Program of the Chinese Academy of Sciences(KJCX2-YWN42)the National Natural Science Foundation of China(11179004,10979055,11205189,and 11205157)the Fundamental Research Funds for the Central Universities(WK2310000021)
基金supported by the National Natural Science Foundation of China under Grant No.11305173
文摘We design a new kind of phase zone plates（PZPs） to improve the diffraction efficiency of soft x ray zone plates（ZPs）. The design replaces blank parts of PZPs with metals of negative phase shift at the working energy, which is called as the positive and negative PZPs（PNPZPs）. According to the calculation, PNPZPs have a higher maximum efficiency than conventional ZPs with the same zone width. With the help of a negative phase coefficient, it is much easier to achieve a π phase shift in one period, resulting in a smaller zone height. This design can help fabricate finer PZPs to achieve a better image resolution.
基金Project supported by the National Research and Development Project for Key Scientific Instruments(Grant No.CZBZDYZ20140002)the National Natural Science Foundation of China(Grant Nos.11535015,11305173,and 11375225)+2 种基金the project supported by Institute of High Energy Physics,Chinese Academy of Sciences(Grant No.Y4545320Y2)the Fundamental Research Funds for the Central Universities(Grant No.WK2310000065)Wali Faiz,acknowledges and wishes to thank the Chinese Academy of Sciences and The World Academy of Sciences(CAS-TWAS)President’s Fellowship Program for generous financial support
文摘Grating-based x-ray phase contrast imaging has the potential to be applied in future medical applications as it is compatible with both laboratory and synchrotron source. However, information retrieval methods are important because acquisition speed, scanning mode, image quality, and radiation dose depend on them. Phase-stepping （PS） is a widely used method to retrieve information, while angular signal radiography （ASR） is a newly established method. In this manuscript, signal-to-noise ratios （SNRs） of ASR are compared with that of PS. Numerical experiments are performed to validate theoretical results. SNRs comparison shows that for refraction and scattering images ASR has higher SNR than PS method, while for absorption image both methods have same SNR. Therefore, our conclusions would have guideline in future preclinical and clinical applications.
