基金supported by the National Natural Science Foundation of China(T2225003 and 82100664)the National Key Research and Development Program of China(2022YFA1105300)+2 种基金Nanjing Medical Science and Technique Development Foundation(ZKX21019)the Clinical Trials from Nanjing Drum Tower Hospital(2022-LCYJ-ZD-01)Guangdong Basic and Applied Basic Research Foundation(2021B1515120054)。