The structure, properties and application to water-soluble coatings of a new complex antimicrobial agent Ag-carboxylmethyl citosan-thiabendazole （Ag-CMCTS-TBZ） prepared from different materiel ratios were reported. ...The structure, properties and application to water-soluble coatings of a new complex antimicrobial agent Ag-carboxylmethyl citosan-thiabendazole （Ag-CMCTS-TBZ） prepared from different materiel ratios were reported. The silver ions were preferably coordinated with the free-NH2 groups and the -OH groups of secondary alcohol and carboxyl in CMCTS. TBZ preferably bonded to carboxyl group in CMCTS by electrostatic force and hydrogen bonding. Increase in silver ions content in the complex agent improved to some limited extent the antibacterial activity, but enhanced coloring and cost of the complex agent. Increase in TBZ content resulted in increase of antifungal activity, but decrease of water solubility of the complex agent. The antimicrobial MICs of the complex agent to Esherichia coil, Staphylococcus aureus, Candida albicans, Aspergillus niger, Mucor sp. were 20 -80, 15 -60, 20 - 55, 40 - 250, and 400 - 1700 mg/kg, respectively. Addition of 0.1% of this complex agent to acrylic emulsion paint made the paint without substantial change in color, luster, viscosity, odor or pH value, but with an excellent and chronically persisting broad-spectra antimicrobial activity.展开更多
文摘The structure, properties and application to water-soluble coatings of a new complex antimicrobial agent Ag-carboxylmethyl citosan-thiabendazole （Ag-CMCTS-TBZ） prepared from different materiel ratios were reported. The silver ions were preferably coordinated with the free-NH2 groups and the -OH groups of secondary alcohol and carboxyl in CMCTS. TBZ preferably bonded to carboxyl group in CMCTS by electrostatic force and hydrogen bonding. Increase in silver ions content in the complex agent improved to some limited extent the antibacterial activity, but enhanced coloring and cost of the complex agent. Increase in TBZ content resulted in increase of antifungal activity, but decrease of water solubility of the complex agent. The antimicrobial MICs of the complex agent to Esherichia coil, Staphylococcus aureus, Candida albicans, Aspergillus niger, Mucor sp. were 20 -80, 15 -60, 20 - 55, 40 - 250, and 400 - 1700 mg/kg, respectively. Addition of 0.1% of this complex agent to acrylic emulsion paint made the paint without substantial change in color, luster, viscosity, odor or pH value, but with an excellent and chronically persisting broad-spectra antimicrobial activity.
文摘大多数哺乳动物中枢神经系统疾病发生后神经细胞轴突受到损伤,由于受损的神经细胞促进轴突再生的能力有限,同时胶质疤痕的生成以及抑制性营养因子的释放,导致受损神经细胞轴突难以再生。为研究注射用脑蛋白水解物(Ⅱ)[cerebroprotein hydrolysate for injection(Ⅱ),CBL]对神经细胞轴突再生的影响及其潜在的分子机制,采用免疫荧光染色检测小鼠脑神经瘤细胞(Neuro-2a)和小鼠原代皮层神经细胞的轴突长度;通过蛋白免疫印迹法检测Neuro-2a细胞和小鼠原代皮层神经细胞内磷酸化TrkB蛋白的表达水平。结果显示:CBL可以促进Neuro-2a细胞和小鼠原代皮层神经细胞的轴突再生,上调神经细胞内TrkB的磷酸化水平;5μg/mL的CBL作用于神经细胞1 h,可以显著升高神经细胞内TrkB磷酸化水平。研究结果表明:CBL可以促进神经细胞轴突再生以及升高TrkB磷酸化水平,提示CBL促进神经细胞轴突再生的作用可能与激活TrkB信号通路有关。
