Background Contrast induced nephropathy（CIN） is associated with increased mortality. serum creatinine（sCr） and serum cystatin C（sCys C） have diagnostic value for CIN in patients taking coronary angiography（CAG...Background Contrast induced nephropathy（CIN） is associated with increased mortality. serum creatinine（sCr） and serum cystatin C（sCys C） have diagnostic value for CIN in patients taking coronary angiography（CAG）. However, whether sCys C is superior to sCr is still controversial. Methods All 280 patients undergoing PCI from July 2015 to July 2017 in Shunde Hospital, Southern Medical University were enrolled in this prospective study. The plasma levels of sCr and sCys C were measured in fasting blood samples in the morning before angiography and at 48 hours and 72 hours after the procedure. Receiver operating characteristic curve（ROC）analysis was performed for sCr and sCys C 48 hours after procedure. Results According to sCys C criteria, CIN occurred in 85 patients（30.4%） after contrast exposure, while, CIN occurred in 22 patients（7.9%）. ROC curve analysis found that AUC for sCr and sCys C was 0.741（P〈0.05, 95% CI = 0.613-0.869） and 0.720（P〈0.05, 95%CI = 0.590-0.851）, respectively without significantly different（P=0.412）. Conclusion The sCys C is not superior to s Cr for predicting CIN in angiography patients.展开更多
基金supported by the Medical scientific research projects of science and technology bureau of Foshan,Guangdong,China(No.2015AB001963)
文摘Background Contrast induced nephropathy（CIN） is associated with increased mortality. serum creatinine（sCr） and serum cystatin C（sCys C） have diagnostic value for CIN in patients taking coronary angiography（CAG）. However, whether sCys C is superior to sCr is still controversial. Methods All 280 patients undergoing PCI from July 2015 to July 2017 in Shunde Hospital, Southern Medical University were enrolled in this prospective study. The plasma levels of sCr and sCys C were measured in fasting blood samples in the morning before angiography and at 48 hours and 72 hours after the procedure. Receiver operating characteristic curve（ROC）analysis was performed for sCr and sCys C 48 hours after procedure. Results According to sCys C criteria, CIN occurred in 85 patients（30.4%） after contrast exposure, while, CIN occurred in 22 patients（7.9%）. ROC curve analysis found that AUC for sCr and sCys C was 0.741（P〈0.05, 95% CI = 0.613-0.869） and 0.720（P〈0.05, 95%CI = 0.590-0.851）, respectively without significantly different（P=0.412）. Conclusion The sCys C is not superior to s Cr for predicting CIN in angiography patients.
