目的观察腰麻-硬膜外联合阻滞麻醉对妊娠期高血压疾病剖宫产患者的麻醉效果及对新生儿的影响。方法选取2014年3月-2015年3月该院妇产科收治的妊娠期高血压疾病、择期行剖宫产的100例患者作为研究对象,按照随机数字表法分为对照组和研究...目的观察腰麻-硬膜外联合阻滞麻醉对妊娠期高血压疾病剖宫产患者的麻醉效果及对新生儿的影响。方法选取2014年3月-2015年3月该院妇产科收治的妊娠期高血压疾病、择期行剖宫产的100例患者作为研究对象,按照随机数字表法分为对照组和研究组,每组50例。对照组采用硬膜外阻滞麻醉方法,研究组采用腰麻-硬膜外联合阻滞麻醉方法,观察两组患者麻醉效果、新生儿娩出1 min Apgar评分、5 min Apgar评分、心率(HR)、收缩压(SBP)、舒张压(DBP)以及不良反应发生率。结果研究组Ⅰ级麻醉效果(86.00%)高于对照组(32.00%),差异有统计学意义(P<0.05);两组新生儿娩出1 min及5 min Apgar评分比较,差异无统计学意义(P>0.05);与麻醉前(T1)时刻比较,两组产妇HR在麻醉平面满意至消毒前(T2)、胎儿娩出(T3)时刻均增快(P<0.05),胎儿娩出10 min(T4)、手术结束(T5)时刻均减慢(P<0.05),且研究组T4、T5时HR水平高于对照组(P<0.05);两组产妇SBP、DBP T1时刻比较,差异无统计学意义(P>0.05),在T2、T3、T4、T5时刻均下降(P<0.05),且研究组产妇在T3时刻SBP、DBP水平高于对照组(P<0.05);研究组不良反应发生率(12.00%)低于对照组(34.00%),差异有统计学意义(P<0.05)。结论腰麻-硬膜外联合阻滞麻醉对妊娠期高血压疾病剖宫产患者具有较好的麻醉效果,对新生儿没有严重影响。展开更多
The implications of Survivin, CyclinD1, p21 WAF1, Caspase-3 in the development, progression and prognosis in cervical cancer were investigated. By using immunohistochemical SP method, the expression of Survivin, Cy...The implications of Survivin, CyclinD1, p21 WAF1, Caspase-3 in the development, progression and prognosis in cervical cancer were investigated. By using immunohistochemical SP method, the expression of Survivin, CyclinD1, p21 WAF1, Caspase-3 was detected in 41 cases of cervical cancer, 17 cases of cervical intraepithelial neoplasia (CIN) and 10 cases of normal tissues, and their relation with pathological grade, clinical stage, metastasis and survival time was analyzed. The results showed that the positive expression rate of Survivin, CyclinD1 in cervical cancer was significantly higher than in CIN group and normal control group (P<0.05). The median survival time in the patients with cervical cancer positive for Survivin and CyclinD1 was significantly shorter than in those with negative expression (P<0.05). The expression of both Survivin and CyclinD1 was not related with tumor grade, clinical stage and metastasis (P>0.05). The positive expression rate of p21 WAF1, Caspase-3 in cervical cancer was significantly lower than in CIN group and normal control group (P<0.05), and had a close relation with tumor grade (P<0.05). The expression of Survivin in cervical cancer in cervical cancer was negatively associated with that of Caspase-3 (P<0.01), but positively with that of CyclinD1 (P<0.01). Cox Multivariate analysis revealed that Survivin was the independent prognostic indicator influencing the survival time of the patients with cervical cancer (P<0.05). It was suggested that the high expression of Survivin or CyclinD1, and low expression of p21 WAF1 or Caspase-3 was closely correlated with the development of cervical cancer. Survivin and CyclinD1 could be used as a useful indicator to predict the prognosis of cervical cancer.展开更多
文摘目的观察腰麻-硬膜外联合阻滞麻醉对妊娠期高血压疾病剖宫产患者的麻醉效果及对新生儿的影响。方法选取2014年3月-2015年3月该院妇产科收治的妊娠期高血压疾病、择期行剖宫产的100例患者作为研究对象,按照随机数字表法分为对照组和研究组,每组50例。对照组采用硬膜外阻滞麻醉方法,研究组采用腰麻-硬膜外联合阻滞麻醉方法,观察两组患者麻醉效果、新生儿娩出1 min Apgar评分、5 min Apgar评分、心率(HR)、收缩压(SBP)、舒张压(DBP)以及不良反应发生率。结果研究组Ⅰ级麻醉效果(86.00%)高于对照组(32.00%),差异有统计学意义(P<0.05);两组新生儿娩出1 min及5 min Apgar评分比较,差异无统计学意义(P>0.05);与麻醉前(T1)时刻比较,两组产妇HR在麻醉平面满意至消毒前(T2)、胎儿娩出(T3)时刻均增快(P<0.05),胎儿娩出10 min(T4)、手术结束(T5)时刻均减慢(P<0.05),且研究组T4、T5时HR水平高于对照组(P<0.05);两组产妇SBP、DBP T1时刻比较,差异无统计学意义(P>0.05),在T2、T3、T4、T5时刻均下降(P<0.05),且研究组产妇在T3时刻SBP、DBP水平高于对照组(P<0.05);研究组不良反应发生率(12.00%)低于对照组(34.00%),差异有统计学意义(P<0.05)。结论腰麻-硬膜外联合阻滞麻醉对妊娠期高血压疾病剖宫产患者具有较好的麻醉效果,对新生儿没有严重影响。
文摘The implications of Survivin, CyclinD1, p21 WAF1, Caspase-3 in the development, progression and prognosis in cervical cancer were investigated. By using immunohistochemical SP method, the expression of Survivin, CyclinD1, p21 WAF1, Caspase-3 was detected in 41 cases of cervical cancer, 17 cases of cervical intraepithelial neoplasia (CIN) and 10 cases of normal tissues, and their relation with pathological grade, clinical stage, metastasis and survival time was analyzed. The results showed that the positive expression rate of Survivin, CyclinD1 in cervical cancer was significantly higher than in CIN group and normal control group (P<0.05). The median survival time in the patients with cervical cancer positive for Survivin and CyclinD1 was significantly shorter than in those with negative expression (P<0.05). The expression of both Survivin and CyclinD1 was not related with tumor grade, clinical stage and metastasis (P>0.05). The positive expression rate of p21 WAF1, Caspase-3 in cervical cancer was significantly lower than in CIN group and normal control group (P<0.05), and had a close relation with tumor grade (P<0.05). The expression of Survivin in cervical cancer in cervical cancer was negatively associated with that of Caspase-3 (P<0.01), but positively with that of CyclinD1 (P<0.01). Cox Multivariate analysis revealed that Survivin was the independent prognostic indicator influencing the survival time of the patients with cervical cancer (P<0.05). It was suggested that the high expression of Survivin or CyclinD1, and low expression of p21 WAF1 or Caspase-3 was closely correlated with the development of cervical cancer. Survivin and CyclinD1 could be used as a useful indicator to predict the prognosis of cervical cancer.
