Chinese medicines （CMs） are increasingly being used for the treatment of tumors because of their unique advantages. The induction of tumor cell apoptosis is an important method of tumor treatment. Caspase-3 is a mem...Chinese medicines （CMs） are increasingly being used for the treatment of tumors because of their unique advantages. The induction of tumor cell apoptosis is an important method of tumor treatment. Caspase-3 is a member of the caspase （cysteine aspartic proteinases） family of enzymes, which are the major inducers of apoptosis. Caspase-3 activity is often measured in the context of research into anti-tumor drugs that target apoptosis. Many studies have shown that CMs upreguiate the expression of caspase-3 in tumor cells via extrinsic and/or intrinsic pathways, removing endogenous suppression of apoptosis and promoting tumor cell death. Therefore, several CMs fulfill the criteria for anti-tumor drugs. In this paper, we review the efficacy of 14 Chinese herbal medicines, across a wide range applications, and discuss their effects on caspase-3 activity in tumor cells.展开更多
医学遗传学是介于基础医学与临床医学之间的桥梁学科,在医学教育中占有重要地位。在医学遗传学基础部分采用传统讲授式教学可以让学生高效、系统地掌握基础知识;在医学遗传学临床部分采用PBL(Problem based learning)教学可以提高学生...医学遗传学是介于基础医学与临床医学之间的桥梁学科,在医学教育中占有重要地位。在医学遗传学基础部分采用传统讲授式教学可以让学生高效、系统地掌握基础知识;在医学遗传学临床部分采用PBL(Problem based learning)教学可以提高学生的学习主动性,加强对学生自主学习能力、分析解决问题能力的培养。将传统讲授式教学与PBL教学有效结合起来可以实现优势互补,在传授知识的同时实现了对学生综合能力的培养。展开更多
基金The Chinese Journal of Integrated Traditional and Western Medicine Press and Springer-Verlag Berlin Heidelberg 2013 Department of Histology and Embryology, Jilin Medical College, Jilin, Jilin Province （132013）, China
文摘Chinese medicines （CMs） are increasingly being used for the treatment of tumors because of their unique advantages. The induction of tumor cell apoptosis is an important method of tumor treatment. Caspase-3 is a member of the caspase （cysteine aspartic proteinases） family of enzymes, which are the major inducers of apoptosis. Caspase-3 activity is often measured in the context of research into anti-tumor drugs that target apoptosis. Many studies have shown that CMs upreguiate the expression of caspase-3 in tumor cells via extrinsic and/or intrinsic pathways, removing endogenous suppression of apoptosis and promoting tumor cell death. Therefore, several CMs fulfill the criteria for anti-tumor drugs. In this paper, we review the efficacy of 14 Chinese herbal medicines, across a wide range applications, and discuss their effects on caspase-3 activity in tumor cells.
文摘医学遗传学是介于基础医学与临床医学之间的桥梁学科,在医学教育中占有重要地位。在医学遗传学基础部分采用传统讲授式教学可以让学生高效、系统地掌握基础知识;在医学遗传学临床部分采用PBL(Problem based learning)教学可以提高学生的学习主动性,加强对学生自主学习能力、分析解决问题能力的培养。将传统讲授式教学与PBL教学有效结合起来可以实现优势互补,在传授知识的同时实现了对学生综合能力的培养。
