Two Cu(Ⅱ) complexes of [Cu(2,6-DPC)(Hnta)(H2O)]·H2O(2,6-DPC = 2,6-pyridinedicarboxylic-carboxylate, Hnta = nicotinic acid) and [Cu2(2,4-D)4(Hnta)2](2,4-D = 2,4-dichlorophenoxyacetic-carboxylate) were synthesized...Two Cu(Ⅱ) complexes of [Cu(2,6-DPC)(Hnta)(H2O)]·H2O(2,6-DPC = 2,6-pyridinedicarboxylic-carboxylate, Hnta = nicotinic acid) and [Cu2(2,4-D)4(Hnta)2](2,4-D = 2,4-dichlorophenoxyacetic-carboxylate) were synthesized and successfully obtained as single crystals in this paper. The supramolecular structures of the complexes from zero to three dimensions and the weak intermolecular force in the crystal were analyzed. The single-crystal structures of the complexes were further analyzed by Hirshfeld surface analysis. The competition capacity of the complexes about calf thymus DNA(ct-DNA) was also analyzed by fluorescence spectroscopy. The ability of complexes to cleave the plasmid DNA(pBR322-DNA) was determined by gel electrophoresis assay. And at last, the complexes’ cytotoxic activities were reviewed for four kinds of cancer cell lines(HeLa, MCF-7, HepG, SKOV-3), showing that the coordination polymer has anti-tumor activity and cytotoxicity.展开更多
基金Supported by the Guizhou Provincial Science and Technology Foundation(No.LKLS[2013]20)the Scientific and Technological Innovation Platform of Liupanshui(52020-2018-02-01 and 52020-2017-02-02)+1 种基金Youth Talent Growth Project of Educational Department of Guizhou Province(No.KY [2017]271)2011 Collaborative Innovation Center of Guizhou Province(Qian Jiao he xietongchuangxin zi [2016]02)
文摘Two Cu(Ⅱ) complexes of [Cu(2,6-DPC)(Hnta)(H2O)]·H2O(2,6-DPC = 2,6-pyridinedicarboxylic-carboxylate, Hnta = nicotinic acid) and [Cu2(2,4-D)4(Hnta)2](2,4-D = 2,4-dichlorophenoxyacetic-carboxylate) were synthesized and successfully obtained as single crystals in this paper. The supramolecular structures of the complexes from zero to three dimensions and the weak intermolecular force in the crystal were analyzed. The single-crystal structures of the complexes were further analyzed by Hirshfeld surface analysis. The competition capacity of the complexes about calf thymus DNA(ct-DNA) was also analyzed by fluorescence spectroscopy. The ability of complexes to cleave the plasmid DNA(pBR322-DNA) was determined by gel electrophoresis assay. And at last, the complexes’ cytotoxic activities were reviewed for four kinds of cancer cell lines(HeLa, MCF-7, HepG, SKOV-3), showing that the coordination polymer has anti-tumor activity and cytotoxicity.
