脑梗死是指不同类型的脑血管疾病引起局部脑组织血流障碍,使脑组织营养及氧供缺乏,导致脑细胞迅速死亡,从而出现局灶性(或全面性)神经功能缺损的临床体征的一类疾病。由于神经细胞的不可再生性,脑梗死成为全球范围内导致死亡及长期残疾...脑梗死是指不同类型的脑血管疾病引起局部脑组织血流障碍,使脑组织营养及氧供缺乏,导致脑细胞迅速死亡,从而出现局灶性(或全面性)神经功能缺损的临床体征的一类疾病。由于神经细胞的不可再生性,脑梗死成为全球范围内导致死亡及长期残疾的主要原因。动脉粥样硬化和血栓形成是脑梗死发生的主要病理基础。有研究表明中性粒细胞与淋巴细胞比值(Ratio of neutrophils to lymphocytes,NLR)、血浆D-二聚体(D-dimer,D-D)与脑梗死发生发展均有相关性,本文拟围绕NLR、D-D与脑梗死的关系进行论述,为脑梗死的及时防治和治疗方案的合理选择提供科学有效的工具。展开更多
Objective There are many clinical reports on traditional Chinese medicine(TCM)combined with nucleoside(acid)analogues(NAs)for the treatment of chronic hepatitis B(CHB),but its efficacy and safety are not completely cl...Objective There are many clinical reports on traditional Chinese medicine(TCM)combined with nucleoside(acid)analogues(NAs)for the treatment of chronic hepatitis B(CHB),but its efficacy and safety are not completely clear.This meta-analysis aims to evaluate the clinical efficacy and safety thus providing evidence for clinical applications.Methods We searched Chinese databases the China National Knowledge Infrastructure(CNKI),Wanfang Data,and China Science and Technology Journal Database(VIP),as well as English databases Pub Med and Cochrane Library,from time of establishment to April 14,2021.Literature quality was evaluated according to the bias risk assessment criteria of Cochrane Collaboration network.Rev Man 5.3 and Stata 12.0 software were used to perform this research.Results A total of 23 articles,3282 patients,and 25 TCM prescriptions were included in this study.NAs plus TCM remarkably improved the clinical total effective rate[Odds ratio(OR)=3.92,P<0.00001],TCM syndrome score(Mean difference=-3.73,P<0.00001),hepatitis B virus(HBV)DNA negative conversion rate(OR=1.49,P=0.0001),hepatitis Be antigen(HBe Ag)negative conversion rate(OR=2.03,P<0.00001),alanine aminotransferase levels[Std mean difference(SMD)=-0.95,P<0.00001],and aspartate aminotransferase levels(SMD=-0.70,P=0.0004).Adverse reaction rates did not increase in the combined treatment group(OR=0.97,P=0.84).A comprehensive analysis of the 25 TCM prescriptions suggested that the combination of spleen-strengthening prescriptions with NAs showed better effects than other prescriptions.Conclusion TCM in combination with NAs,demonstrated better clinical efficacy against CHB than NAs alone.In addition,the combination of spleen-strengthening prescriptions and NAs was identified as the best therapeutic strategy.However,more randomized controlled trials of high quality are needed to provide more reliable clinical basis for the application of TCM.展开更多
文摘急性脑梗死(acute cerebral infarct,ACI)也称急性缺血性脑卒中(acute ischemic stroke,AIS),是我国最常见的脑卒中类型,有高发病率、高致残率、高复发率、高致死率特点,现仍然是一个重点关注的问题。因此对其治疗前、治疗中以及预后的研究脚步从未停止,我们致力于为ACI患者寻找对ACI早期筛查、尽早预测的血清标记物,以便于在临床上更好的指导ACI的治疗、判断其预后。在这篇综述中,我们主要探讨关于单核细胞与高密度脂蛋白比值(monocyte to high density lipoprotein ratio,MHR)、血尿酸(blood uric acid,SUA)分别与动脉粥样硬化、缺血性卒中的病情程度及预后的关系,旨在为ACI的防治决策提供一定的临床理论依据。
文摘脑梗死是指不同类型的脑血管疾病引起局部脑组织血流障碍,使脑组织营养及氧供缺乏,导致脑细胞迅速死亡,从而出现局灶性(或全面性)神经功能缺损的临床体征的一类疾病。由于神经细胞的不可再生性,脑梗死成为全球范围内导致死亡及长期残疾的主要原因。动脉粥样硬化和血栓形成是脑梗死发生的主要病理基础。有研究表明中性粒细胞与淋巴细胞比值(Ratio of neutrophils to lymphocytes,NLR)、血浆D-二聚体(D-dimer,D-D)与脑梗死发生发展均有相关性,本文拟围绕NLR、D-D与脑梗死的关系进行论述,为脑梗死的及时防治和治疗方案的合理选择提供科学有效的工具。
基金We thank for the funding support from the Hundred Talents Program of Hunan Province(No.9999004007)the Startup grant of Hunan University of Chinese Medicine(No.999900201107).
文摘Objective There are many clinical reports on traditional Chinese medicine(TCM)combined with nucleoside(acid)analogues(NAs)for the treatment of chronic hepatitis B(CHB),but its efficacy and safety are not completely clear.This meta-analysis aims to evaluate the clinical efficacy and safety thus providing evidence for clinical applications.Methods We searched Chinese databases the China National Knowledge Infrastructure(CNKI),Wanfang Data,and China Science and Technology Journal Database(VIP),as well as English databases Pub Med and Cochrane Library,from time of establishment to April 14,2021.Literature quality was evaluated according to the bias risk assessment criteria of Cochrane Collaboration network.Rev Man 5.3 and Stata 12.0 software were used to perform this research.Results A total of 23 articles,3282 patients,and 25 TCM prescriptions were included in this study.NAs plus TCM remarkably improved the clinical total effective rate[Odds ratio(OR)=3.92,P<0.00001],TCM syndrome score(Mean difference=-3.73,P<0.00001),hepatitis B virus(HBV)DNA negative conversion rate(OR=1.49,P=0.0001),hepatitis Be antigen(HBe Ag)negative conversion rate(OR=2.03,P<0.00001),alanine aminotransferase levels[Std mean difference(SMD)=-0.95,P<0.00001],and aspartate aminotransferase levels(SMD=-0.70,P=0.0004).Adverse reaction rates did not increase in the combined treatment group(OR=0.97,P=0.84).A comprehensive analysis of the 25 TCM prescriptions suggested that the combination of spleen-strengthening prescriptions with NAs showed better effects than other prescriptions.Conclusion TCM in combination with NAs,demonstrated better clinical efficacy against CHB than NAs alone.In addition,the combination of spleen-strengthening prescriptions and NAs was identified as the best therapeutic strategy.However,more randomized controlled trials of high quality are needed to provide more reliable clinical basis for the application of TCM.
