The purpose of this study is to elucidate the mechanism of delaying aging process under proper stress. An aging model was established by intraperitoneal injection of D galactose at the dose of 0.12 mg·(g·d)...The purpose of this study is to elucidate the mechanism of delaying aging process under proper stress. An aging model was established by intraperitoneal injection of D galactose at the dose of 0.12 mg·(g·d) -1 for six weeks, and swimming daily for 15min at 18℃ water was used as proper stressor. Six weeks later, learning and memory ability, the contents of SOD and MDA in hippocampus and heart were measured. The results showed that proper stress could ①retard the decline of learning and memory ability (P<0.001) induced by D galactose;②increase the content of SOD (P<0.001) and reduce the production of MDA (P<0.05). The results indicated that proper stress may delay aging process by improving the antioxidant level and reducing the toxicity of free radicals.展开更多
文摘The purpose of this study is to elucidate the mechanism of delaying aging process under proper stress. An aging model was established by intraperitoneal injection of D galactose at the dose of 0.12 mg·(g·d) -1 for six weeks, and swimming daily for 15min at 18℃ water was used as proper stressor. Six weeks later, learning and memory ability, the contents of SOD and MDA in hippocampus and heart were measured. The results showed that proper stress could ①retard the decline of learning and memory ability (P<0.001) induced by D galactose;②increase the content of SOD (P<0.001) and reduce the production of MDA (P<0.05). The results indicated that proper stress may delay aging process by improving the antioxidant level and reducing the toxicity of free radicals.
