目的探究血浆微小RNA(microRNA,miR)-497-5p、miR-331-5p与缺血性脑卒中(ischemic stroke,IS)患者神经功能缺损程度及脑卒中后抑郁(post stroke depression,PSD)的相关性。方法选取2021年7月至2023年7月于南阳医学高等专科学校第一附属...目的探究血浆微小RNA(microRNA,miR)-497-5p、miR-331-5p与缺血性脑卒中(ischemic stroke,IS)患者神经功能缺损程度及脑卒中后抑郁(post stroke depression,PSD)的相关性。方法选取2021年7月至2023年7月于南阳医学高等专科学校第一附属医院就诊的IS患者191例作为研究组,另选取同期健康体检者191例作为对照组。根据美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)分为轻型缺损组82例、中型缺损组68例和重型缺损组41例。根据汉密尔顿抑郁量表分为非PSD组112例和PSD组79例。Pearson相关性分析、Spearman相关性分析血浆miR-497-5p、miR-331-5p与NIHSS评分的相关性,采用多因素logistic回归分析IS患者发生PSD的危险因素,采用ROC曲线分析血浆miR-497-5p、miR-331-5p水平对IS患者发生PSD的预测价值。结果研究组血浆miR-497-5p、miR-331-5p水平显著高于对照组(P<0.01)。轻型缺损组、中型缺损组和重型缺损组血浆miR-497-5p、miR-331-5p水平和NIHSS评分依次显著升高,3组比较,差异有统计学意义(P<0.01)。miR-497-5p、miR-331-5p与NIHSS评分均呈正相关(P<0.01)。PSD组重型缺损、miR-497-5p、miR-331-5p水平显著高于非PSD组(P<0.01)。多因素logistic回归分析显示,miR-497-5p、miR-331-5p、重型缺损为IS患者发生PSD的危险因素(OR=3.248,95%CI:1.623~6.501;OR=4.258,95%CI:1.739~10.428;OR=2.261,95%CI:1.261~4.055)。血浆miR-497-5p预测IS患者发生PSD的曲线下面积(area under curve,AUC)为0.836,血浆miR-331-5p预测IS患者发生PSD的AUC为0.817,二者联合预测IS患者发生PSD的AUC为0.911,显著优于单独预测(P<0.05)。结论IS患者血浆miR-497-5p、miR-331-5p水平显著升高,与神经功能缺损程度及PSD发生情况密切相关,二者联合对IS患者发生PSD的预测价值较好。展开更多
The visco-plastic self-consistent (VPSC) model is extended to take the dynamical recrystallization (DRX) into account so that the hot extrusion texture of AZ80 magnesium alloy can be properly modeled. The effects of e...The visco-plastic self-consistent (VPSC) model is extended to take the dynamical recrystallization (DRX) into account so that the hot extrusion texture of AZ80 magnesium alloy can be properly modeled. The effects of extrusion temperatures and imposed boundary conditions on the resulting textures were investigated, and good agreement can be found between the simulated and the measured extrusion textures. The simulated results show that the DRX grains are responsible for the formation of the {2110} fiber component since the {1010} poles of the DRX grains are tilted away from those of the unrecrystallized grains during the formation of their high angle boundaries (HABs). Furthermore, the basal poles of the grains are favorably oriented to the transversal direction (TD) where the imposed deformation is larger due to lower slip resistance of the basal slip. The elevated temperature enhances the activity of pyramidal ?c+a? slip modes and gives rise to a larger recrystallized volume fraction, resulting in a weakened extrusion texture.展开更多
文摘目的探究血浆微小RNA(microRNA,miR)-497-5p、miR-331-5p与缺血性脑卒中(ischemic stroke,IS)患者神经功能缺损程度及脑卒中后抑郁(post stroke depression,PSD)的相关性。方法选取2021年7月至2023年7月于南阳医学高等专科学校第一附属医院就诊的IS患者191例作为研究组,另选取同期健康体检者191例作为对照组。根据美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)分为轻型缺损组82例、中型缺损组68例和重型缺损组41例。根据汉密尔顿抑郁量表分为非PSD组112例和PSD组79例。Pearson相关性分析、Spearman相关性分析血浆miR-497-5p、miR-331-5p与NIHSS评分的相关性,采用多因素logistic回归分析IS患者发生PSD的危险因素,采用ROC曲线分析血浆miR-497-5p、miR-331-5p水平对IS患者发生PSD的预测价值。结果研究组血浆miR-497-5p、miR-331-5p水平显著高于对照组(P<0.01)。轻型缺损组、中型缺损组和重型缺损组血浆miR-497-5p、miR-331-5p水平和NIHSS评分依次显著升高,3组比较,差异有统计学意义(P<0.01)。miR-497-5p、miR-331-5p与NIHSS评分均呈正相关(P<0.01)。PSD组重型缺损、miR-497-5p、miR-331-5p水平显著高于非PSD组(P<0.01)。多因素logistic回归分析显示,miR-497-5p、miR-331-5p、重型缺损为IS患者发生PSD的危险因素(OR=3.248,95%CI:1.623~6.501;OR=4.258,95%CI:1.739~10.428;OR=2.261,95%CI:1.261~4.055)。血浆miR-497-5p预测IS患者发生PSD的曲线下面积(area under curve,AUC)为0.836,血浆miR-331-5p预测IS患者发生PSD的AUC为0.817,二者联合预测IS患者发生PSD的AUC为0.911,显著优于单独预测(P<0.05)。结论IS患者血浆miR-497-5p、miR-331-5p水平显著升高,与神经功能缺损程度及PSD发生情况密切相关,二者联合对IS患者发生PSD的预测价值较好。
基金Project(311017)supported by the Major Projects of the Ministry of EducationProjects(51175335,51305261)supported by the National Natural Science Foundation of ChinaProject(2013M530194)supported by the Postdoctoral Science Foundation of China
文摘The visco-plastic self-consistent (VPSC) model is extended to take the dynamical recrystallization (DRX) into account so that the hot extrusion texture of AZ80 magnesium alloy can be properly modeled. The effects of extrusion temperatures and imposed boundary conditions on the resulting textures were investigated, and good agreement can be found between the simulated and the measured extrusion textures. The simulated results show that the DRX grains are responsible for the formation of the {2110} fiber component since the {1010} poles of the DRX grains are tilted away from those of the unrecrystallized grains during the formation of their high angle boundaries (HABs). Furthermore, the basal poles of the grains are favorably oriented to the transversal direction (TD) where the imposed deformation is larger due to lower slip resistance of the basal slip. The elevated temperature enhances the activity of pyramidal ?c+a? slip modes and gives rise to a larger recrystallized volume fraction, resulting in a weakened extrusion texture.
