We synthesized optically active 2-(8′-diphenylphosphino-1′-naphthyl)oxazoline ligands by palladium-catalyzed coupling reactions of (trimethylsilyl)diphenylphosphine with 2-(8′-bromo-1′-naphthyl)oxazolines, which, ...We synthesized optically active 2-(8′-diphenylphosphino-1′-naphthyl)oxazoline ligands by palladium-catalyzed coupling reactions of (trimethylsilyl)diphenylphosphine with 2-(8′-bromo-1′-naphthyl)oxazolines, which, in turn, were prepared from 8-bromo-1-naphthoyl chloride by the reaction with natural optical active amino alcohols. Pd-Catalyzed allylic alkylation reaction induced by these chiral ligands gave the allylic substituted products in high yields and moderate ee values.展开更多
Due to the chemoselective dehalogenation by SmI2, the addition of α-halomethylsulfones to carbonyl compounds afforded β-hy-droxysulfones. Those reactions with α-bromomethylsulfones gave the products in moderate to ...Due to the chemoselective dehalogenation by SmI2, the addition of α-halomethylsulfones to carbonyl compounds afforded β-hy-droxysulfones. Those reactions with α-bromomethylsulfones gave the products in moderate to good yields. The SmI2-mediat-ed addition of gem-dihalomethylsulfones to ketones also afforded α-halo-β-hydroxysulfones in moderate yields.展开更多
文摘We synthesized optically active 2-(8′-diphenylphosphino-1′-naphthyl)oxazoline ligands by palladium-catalyzed coupling reactions of (trimethylsilyl)diphenylphosphine with 2-(8′-bromo-1′-naphthyl)oxazolines, which, in turn, were prepared from 8-bromo-1-naphthoyl chloride by the reaction with natural optical active amino alcohols. Pd-Catalyzed allylic alkylation reaction induced by these chiral ligands gave the allylic substituted products in high yields and moderate ee values.
基金Project supported by the National Natural Science Foundation of China(No.20272050).
文摘Due to the chemoselective dehalogenation by SmI2, the addition of α-halomethylsulfones to carbonyl compounds afforded β-hy-droxysulfones. Those reactions with α-bromomethylsulfones gave the products in moderate to good yields. The SmI2-mediat-ed addition of gem-dihalomethylsulfones to ketones also afforded α-halo-β-hydroxysulfones in moderate yields.
