目的分析膳食模式与育龄人群性功能的关联。方法本研究为横断面研究,纳入2020年12月至2022年3月期间在安徽省马鞍山市妇幼保健院生殖中心、中国人民解放军联勤保障部队第901医院生殖中心和安徽皖北煤电集团总医院生殖中心就诊的所有女...目的分析膳食模式与育龄人群性功能的关联。方法本研究为横断面研究,纳入2020年12月至2022年3月期间在安徽省马鞍山市妇幼保健院生殖中心、中国人民解放军联勤保障部队第901医院生殖中心和安徽皖北煤电集团总医院生殖中心就诊的所有女性和男性作为研究对象,通过女性性功能指数(Female Sexual Function Index,FSFI)和国际勃起功能指数-15(International Index of Erectile Function-15,IIEF-15)问卷评估性功能,采用因子分析建立膳食模式,采用多因素logistic回归分析膳食模式与性功能的相关性。结果研究共纳入1290例女性、1331例男性,其中女性性功能障碍者1031例,男性性功能障碍者899例,均衡型膳食模式为主的女性289例、男性272例,传统型膳食模式为主的女性473例、男性395例,加工型膳食模式为主的女性272例、男性324例,饮料型膳食模式为主的女性256例、男性340例。调整居住地、年龄等混杂因素后发现,均衡型膳食模式与女性性欲障碍(OR=0.904,95%CI:0.820~0.995,P=0.039)、性唤起障碍(OR=0.840,95%CI:0.759~0.929,P=0.001)、阴道润滑障碍(OR=0.833,95%CI:0.710~0.979,P=0.026)、性高潮障碍(OR=0.764,95%CI:0.680~0.858,P<0.001)、性满意度低(OR=0.887,95%CI:0.796~0.987,P=0.028)、性功能障碍(OR=0.805,95%CI:0.714~0.907,P<0.001)和男性性高潮障碍(OR=0.859,95%CI:0.763~0.967,P=0.012)呈负相关;传统型膳食模式与女性性欲障碍(OR=0.879,95%CI:0.786~0.983,P=0.024)、性唤起障碍(OR=0.884,95%CI:0.784~0.995,P=0.042)和男性勃起功能障碍(OR=0.736,95%CI:0.634~0.855,P<0.001)、性欲障碍(OR=0.753,95%CI:0.648~0.876,P<0.001)、性功能障碍(OR=0.769,95%CI:0.653~0.907,P=0.020)呈负相关;加工型膳食模式与男性勃起功能障碍(OR=1.162,95%CI:1.049~1.287,P=0.004)、性高潮障碍(OR=1.207,95%CI:1.091~1.337,P<0.001)、性欲障碍(OR=1.199,95%CI:1.081~1.330,P=0.001)、性功能障碍(OR=1.134,95%CI:1.020~1.261,P=0.002)呈正相关;饮料型膳食模式与男�展开更多
[Objective] This study aimed to investigate the acute oral toxicity of crude monkshood （Radix aconiti lateralis preparata）. [Method] Monkshood alcohol extract was prepared using soxhlet extractor. The maximum drug d...[Objective] This study aimed to investigate the acute oral toxicity of crude monkshood （Radix aconiti lateralis preparata）. [Method] Monkshood alcohol extract was prepared using soxhlet extractor. The maximum drug dose, which was the minimum dose causing 100% lethally rate in the preliminary test, was diluted into seven con- centrations in formal test. Then every mouse was orally administrated with 0.04 ml/g of the monkshood solution at single time for 7 d. Median lethal dose （LD50） and 95% confidence limit were calculated by the improved Karber method formulas. [Result] LD50 of monkshood ethanol extract was 230.12 mg/kg and 95% confidence limit of LD50 was 80.39-658.57 mg/kg. [Conclusion] Crude monkshood alcohol extract can quickly induce acute toxicity in mice.展开更多
文摘目的分析膳食模式与育龄人群性功能的关联。方法本研究为横断面研究,纳入2020年12月至2022年3月期间在安徽省马鞍山市妇幼保健院生殖中心、中国人民解放军联勤保障部队第901医院生殖中心和安徽皖北煤电集团总医院生殖中心就诊的所有女性和男性作为研究对象,通过女性性功能指数(Female Sexual Function Index,FSFI)和国际勃起功能指数-15(International Index of Erectile Function-15,IIEF-15)问卷评估性功能,采用因子分析建立膳食模式,采用多因素logistic回归分析膳食模式与性功能的相关性。结果研究共纳入1290例女性、1331例男性,其中女性性功能障碍者1031例,男性性功能障碍者899例,均衡型膳食模式为主的女性289例、男性272例,传统型膳食模式为主的女性473例、男性395例,加工型膳食模式为主的女性272例、男性324例,饮料型膳食模式为主的女性256例、男性340例。调整居住地、年龄等混杂因素后发现,均衡型膳食模式与女性性欲障碍(OR=0.904,95%CI:0.820~0.995,P=0.039)、性唤起障碍(OR=0.840,95%CI:0.759~0.929,P=0.001)、阴道润滑障碍(OR=0.833,95%CI:0.710~0.979,P=0.026)、性高潮障碍(OR=0.764,95%CI:0.680~0.858,P<0.001)、性满意度低(OR=0.887,95%CI:0.796~0.987,P=0.028)、性功能障碍(OR=0.805,95%CI:0.714~0.907,P<0.001)和男性性高潮障碍(OR=0.859,95%CI:0.763~0.967,P=0.012)呈负相关;传统型膳食模式与女性性欲障碍(OR=0.879,95%CI:0.786~0.983,P=0.024)、性唤起障碍(OR=0.884,95%CI:0.784~0.995,P=0.042)和男性勃起功能障碍(OR=0.736,95%CI:0.634~0.855,P<0.001)、性欲障碍(OR=0.753,95%CI:0.648~0.876,P<0.001)、性功能障碍(OR=0.769,95%CI:0.653~0.907,P=0.020)呈负相关;加工型膳食模式与男性勃起功能障碍(OR=1.162,95%CI:1.049~1.287,P=0.004)、性高潮障碍(OR=1.207,95%CI:1.091~1.337,P<0.001)、性欲障碍(OR=1.199,95%CI:1.081~1.330,P=0.001)、性功能障碍(OR=1.134,95%CI:1.020~1.261,P=0.002)呈正相关;饮料型膳食模式与男�
基金Supported by the National Natural Science Foundation of China (31201951)~~
文摘[Objective] This study aimed to investigate the acute oral toxicity of crude monkshood （Radix aconiti lateralis preparata）. [Method] Monkshood alcohol extract was prepared using soxhlet extractor. The maximum drug dose, which was the minimum dose causing 100% lethally rate in the preliminary test, was diluted into seven con- centrations in formal test. Then every mouse was orally administrated with 0.04 ml/g of the monkshood solution at single time for 7 d. Median lethal dose （LD50） and 95% confidence limit were calculated by the improved Karber method formulas. [Result] LD50 of monkshood ethanol extract was 230.12 mg/kg and 95% confidence limit of LD50 was 80.39-658.57 mg/kg. [Conclusion] Crude monkshood alcohol extract can quickly induce acute toxicity in mice.
