Objective To evaluate the effect on inflammatory response and dose-response relationship of lidocaine pretreatment in Endotoxin-induced acute lung injury rabbit model.Methods Thirty anesthetized rabbits were randomly ...Objective To evaluate the effect on inflammatory response and dose-response relationship of lidocaine pretreatment in Endotoxin-induced acute lung injury rabbit model.Methods Thirty anesthetized rabbits were randomly divided into six groups(n = 5 each).Lung injury was induced in rabbits by intravenous infusion of Escbericbia coli endotoxin(100 μg/kg over a 60 min period).10 min before infusion of endotoxin, one group was assigned to receive intravenous infusion of saline(as control);while others received intravenous infusion of lidocaine at different concentrations. Homodynamics, arterial oxygen tension and cytokines concentrations in plasma were recorded. The lung wet-to-dry-weight ratio was analyzed as an index of pulmonary edema. Light microscopic findings (lung injury score) were compared in the six groups. Results Endotoxin caused marked decrease in arterial oxygen tension, and increase in the lung wet-to dry-weight ratio, interleukin-6,interleukin-10 and tumor necrosis factor-α in plasma. Lidocaine pretreatment attenuated these changes significantly (P<0.05). Endotoxin increased lung injury score. These changes were attenuated by lidocaine significantly in relation with its doses(P<0.05). Conclusion Results suggest that intravenous lidocaine pretreatment might attenuates inflammatory response in relation with its doses in endotoxin-induced acute lung injury rabbit model.展开更多
文摘目的探讨参考《患者离室标准》制定的《转运前护理观察指标》应用于全麻手术患者的效果。方法便利抽样选择2013年5-8月南方医院300例成年择期行全身麻醉的手术患者,按手术时间分成两组,对照组(control group)患者由麻醉恢复室(post-anesthesia care unit,PACU)医生在患者离室标准的基础上,根据个人经验观察后,进行Steward评分,之后通知护士转运;观察组(observation group)患者由PACU护士按照《转运前护理观察指标》的要求进行判断,满足条件后通知PACU医生进行Steward评分,之后遵医嘱转送。比较两组患者满足转送条件时间、实际转送时间、转送至病房后术后基本情况的差异。结果观察组患者PACU的满足转运条件时间和实际转运时间均明显短于对照组(均P<0.05);两组患者转送至病房后不良事件发生率差异无统计学意义(均P>0.05)。结论麻醉护士执行预先制定的《转运前护理观察指标》,主动进行患者转运前病情观察,可明显缩短患者留置PACU时间,提高医疗和护理工作效率。
文摘Objective To evaluate the effect on inflammatory response and dose-response relationship of lidocaine pretreatment in Endotoxin-induced acute lung injury rabbit model.Methods Thirty anesthetized rabbits were randomly divided into six groups(n = 5 each).Lung injury was induced in rabbits by intravenous infusion of Escbericbia coli endotoxin(100 μg/kg over a 60 min period).10 min before infusion of endotoxin, one group was assigned to receive intravenous infusion of saline(as control);while others received intravenous infusion of lidocaine at different concentrations. Homodynamics, arterial oxygen tension and cytokines concentrations in plasma were recorded. The lung wet-to-dry-weight ratio was analyzed as an index of pulmonary edema. Light microscopic findings (lung injury score) were compared in the six groups. Results Endotoxin caused marked decrease in arterial oxygen tension, and increase in the lung wet-to dry-weight ratio, interleukin-6,interleukin-10 and tumor necrosis factor-α in plasma. Lidocaine pretreatment attenuated these changes significantly (P<0.05). Endotoxin increased lung injury score. These changes were attenuated by lidocaine significantly in relation with its doses(P<0.05). Conclusion Results suggest that intravenous lidocaine pretreatment might attenuates inflammatory response in relation with its doses in endotoxin-induced acute lung injury rabbit model.
