建立了超高效液相色谱-串联质谱法(UHPLC-MS-MS)同时测定化妆品中21种性激素含量的分析方法。水状、乳状、油状的化妆品采用甲醇/乙腈(1∶1,V/V)漩涡提取,利用HLB固相萃取柱净化萃取,选取4 m L乙腈为洗脱液收集样品液后,经C18色谱柱分离...建立了超高效液相色谱-串联质谱法(UHPLC-MS-MS)同时测定化妆品中21种性激素含量的分析方法。水状、乳状、油状的化妆品采用甲醇/乙腈(1∶1,V/V)漩涡提取,利用HLB固相萃取柱净化萃取,选取4 m L乙腈为洗脱液收集样品液后,经C18色谱柱分离,以甲醇-乙腈及0.5 mmol/L乙酸铵水溶液为流动相进行梯度洗脱,采用动态多反应监测(d MRM)扫描方式进行测定。21种性激素成分在25~800 ng/m L范围内呈良好的线性关系,其相关系数(r2)均大于0.999,方法定量限(LOQs)为0.05~0.61 mg/kg。此外,高、低两个浓度加标水平的实验结果表明,方法平均回收率为74%!110%,相对标准偏差(RSD)为1.2%~10%(n=3)。展开更多
AR数字沙盘是一种交互性强的多媒体教具,具有直观性、动态性、交互性等特点,可以为学生提供全新的学习体验。地理空间思维能力在地理学科中扮演着重要的角色,对初中生进行这方面的培养尤为重要。本研究使用实验对照法,以楚雄师院附中初...AR数字沙盘是一种交互性强的多媒体教具,具有直观性、动态性、交互性等特点,可以为学生提供全新的学习体验。地理空间思维能力在地理学科中扮演着重要的角色,对初中生进行这方面的培养尤为重要。本研究使用实验对照法,以楚雄师院附中初二年级的学生为研究对象,通过将AR数字沙盘模型应用到《地形图的判读》一课的教学当中,设计AR沙盘教学任务,通过小节测试的手段评估教学质量及效果。分析学生在使用AR数字沙盘以后,地理空间思维能力的变化。研究结果表明,AR数字沙盘能够帮助学生沉浸式的体验和理解地理概念,加深对地理空间关系的认识。数字沙盘与传统教学方法相比较,能够激发学生的学习兴趣,进而培养他们的思维能力。AR digital sandbox is a highly interactive multimedia teaching tool with characteristics such as intuitiveness, dynamism, and interactivity, which can provide students with a brand new learning experience. The ability of geospatial thinking plays an important role in the field of geography, and it is particularly important to cultivate middle school students in this area. This study used an experimental control method, with second grade students from Chuxiong Normal University Affiliated Middle School as the research subjects. By applying the AR digital sandbox model to the teaching of “Interpretation of Topographic Maps”, an AR sandbox teaching task was designed, and the teaching quality and effect were evaluated through section testing. Analyze the changes in students’ geospatial thinking abilities after using the AR digital sandbox. The research results indicate that AR digital sandbox can help students immerse themselves in experiencing and understanding geographical concepts, deepening their understanding of geographical spatial relationships. Compared with traditional teaching methods, digital sandbox can stimulate students’ interest in learning and cultivate their thinki展开更多
文摘AR数字沙盘是一种交互性强的多媒体教具,具有直观性、动态性、交互性等特点,可以为学生提供全新的学习体验。地理空间思维能力在地理学科中扮演着重要的角色,对初中生进行这方面的培养尤为重要。本研究使用实验对照法,以楚雄师院附中初二年级的学生为研究对象,通过将AR数字沙盘模型应用到《地形图的判读》一课的教学当中,设计AR沙盘教学任务,通过小节测试的手段评估教学质量及效果。分析学生在使用AR数字沙盘以后,地理空间思维能力的变化。研究结果表明,AR数字沙盘能够帮助学生沉浸式的体验和理解地理概念,加深对地理空间关系的认识。数字沙盘与传统教学方法相比较,能够激发学生的学习兴趣,进而培养他们的思维能力。AR digital sandbox is a highly interactive multimedia teaching tool with characteristics such as intuitiveness, dynamism, and interactivity, which can provide students with a brand new learning experience. The ability of geospatial thinking plays an important role in the field of geography, and it is particularly important to cultivate middle school students in this area. This study used an experimental control method, with second grade students from Chuxiong Normal University Affiliated Middle School as the research subjects. By applying the AR digital sandbox model to the teaching of “Interpretation of Topographic Maps”, an AR sandbox teaching task was designed, and the teaching quality and effect were evaluated through section testing. Analyze the changes in students’ geospatial thinking abilities after using the AR digital sandbox. The research results indicate that AR digital sandbox can help students immerse themselves in experiencing and understanding geographical concepts, deepening their understanding of geographical spatial relationships. Compared with traditional teaching methods, digital sandbox can stimulate students’ interest in learning and cultivate their thinki
