目的:系统评价小檗碱对于肥胖人群治疗的疗效。方法:采用计算机检索CNKI、CBM、WangFang、VIP、PubMed、Embase、Cochrane Library数据库,查找有关小檗碱对于肥胖人群治疗的随机对照试验研究,检索时间为建库至2023年12月,应用Stata 15....目的:系统评价小檗碱对于肥胖人群治疗的疗效。方法:采用计算机检索CNKI、CBM、WangFang、VIP、PubMed、Embase、Cochrane Library数据库,查找有关小檗碱对于肥胖人群治疗的随机对照试验研究,检索时间为建库至2023年12月,应用Stata 15.1软件对纳入的研究进行Meta分析。结果:最终有8项随机对照试验被纳入。Meta分析结果显示,与对照组相比,小檗碱组可有效降低受试者BMI值[SMD = −0.67, 95% CI (−0.91, −0.44), P P P P P Objective: To review the efficacy of berberine in the treatment of obese people. Method: CNKI, CBM, WangFang Date, VIP databases, PubMed, Embase and Cochrane Library were searched in computer to find randomized controlled trials of berberine in obese people from library establishment to December 2023. Stata 15.1 software was used to conduct a meta-analysis of the included studies. Result: Eight randomized controlled trials were included. The results of meta-analysis found that compared with control group, berberine group was more effective in reducing the BMI of the subject [SMD = −0.67, 95% CI (−0.91, −0.44), P P P P P < 0.001]. Conclusion: Current evidence suggests that berberine is more effective in the treatment of obese people, effectively reducing BMI and lipid levels.展开更多
目的:系统评价糖尿病患者同型半胱氨酸(Hcy)和尿酸(UA)的相关性。方法:采用计算机检索CNKI、CBM、WangFang、PubMed、Embase、Web of science、Cochrane Library数据库,查找糖尿病患者Hcy与UA相关性的研究,检索时间为建库至2024年2月,应...目的:系统评价糖尿病患者同型半胱氨酸(Hcy)和尿酸(UA)的相关性。方法:采用计算机检索CNKI、CBM、WangFang、PubMed、Embase、Web of science、Cochrane Library数据库,查找糖尿病患者Hcy与UA相关性的研究,检索时间为建库至2024年2月,应用Stata 17.0软件对纳入的研究进行Meta分析。结果:20项研究纳入本荟萃分析。在整体糖尿病人群中,Hcy与UA的相关性有统计学意义[ES = 0.54, 95% CI (0.39, 0.69), P < 0.001];在单纯糖尿病亚组分析中,Hcy与UA的相关性有统计学意义[ES = 0.24, 95% CI (0.2, 0.29), P < 0.001];在糖尿病肾病亚组中,Hcy与UA的相关性有统计学意义[ES = 0.59, 95% CI (0.31, 0.88), P < 0.001];在糖尿病合并高血压亚组分析中,Hcy与UA的相关性有统计学意义[ES = 0.99, 95% CI (0.80, 1.18), P < 0.001];在糖尿病合并高尿酸(HUA)的亚组分析中,Hcy与UA的相关性有统计学意义[ES = 0.71, 95% CI (0.28, 1.14), P < 0.001]。结论:在糖尿病合并高血压和HUA的患者中,Hcy与UA的相关性更强,在单纯糖尿病和糖尿病肾病患者中,Hcy与UA的相关性弱一些。积极控制Hcy和UA的水平对于糖尿病患者预后有着重要的影响。展开更多
文摘目的:系统评价小檗碱对于肥胖人群治疗的疗效。方法:采用计算机检索CNKI、CBM、WangFang、VIP、PubMed、Embase、Cochrane Library数据库,查找有关小檗碱对于肥胖人群治疗的随机对照试验研究,检索时间为建库至2023年12月,应用Stata 15.1软件对纳入的研究进行Meta分析。结果:最终有8项随机对照试验被纳入。Meta分析结果显示,与对照组相比,小檗碱组可有效降低受试者BMI值[SMD = −0.67, 95% CI (−0.91, −0.44), P P P P P Objective: To review the efficacy of berberine in the treatment of obese people. Method: CNKI, CBM, WangFang Date, VIP databases, PubMed, Embase and Cochrane Library were searched in computer to find randomized controlled trials of berberine in obese people from library establishment to December 2023. Stata 15.1 software was used to conduct a meta-analysis of the included studies. Result: Eight randomized controlled trials were included. The results of meta-analysis found that compared with control group, berberine group was more effective in reducing the BMI of the subject [SMD = −0.67, 95% CI (−0.91, −0.44), P P P P P < 0.001]. Conclusion: Current evidence suggests that berberine is more effective in the treatment of obese people, effectively reducing BMI and lipid levels.
文摘目的:系统评价糖尿病患者同型半胱氨酸(Hcy)和尿酸(UA)的相关性。方法:采用计算机检索CNKI、CBM、WangFang、PubMed、Embase、Web of science、Cochrane Library数据库,查找糖尿病患者Hcy与UA相关性的研究,检索时间为建库至2024年2月,应用Stata 17.0软件对纳入的研究进行Meta分析。结果:20项研究纳入本荟萃分析。在整体糖尿病人群中,Hcy与UA的相关性有统计学意义[ES = 0.54, 95% CI (0.39, 0.69), P < 0.001];在单纯糖尿病亚组分析中,Hcy与UA的相关性有统计学意义[ES = 0.24, 95% CI (0.2, 0.29), P < 0.001];在糖尿病肾病亚组中,Hcy与UA的相关性有统计学意义[ES = 0.59, 95% CI (0.31, 0.88), P < 0.001];在糖尿病合并高血压亚组分析中,Hcy与UA的相关性有统计学意义[ES = 0.99, 95% CI (0.80, 1.18), P < 0.001];在糖尿病合并高尿酸(HUA)的亚组分析中,Hcy与UA的相关性有统计学意义[ES = 0.71, 95% CI (0.28, 1.14), P < 0.001]。结论:在糖尿病合并高血压和HUA的患者中,Hcy与UA的相关性更强,在单纯糖尿病和糖尿病肾病患者中,Hcy与UA的相关性弱一些。积极控制Hcy和UA的水平对于糖尿病患者预后有着重要的影响。
