慢性肾脏病基础上的急性肾衰竭（ARF on CKD或A／C）是指患者在原有慢性肾脏病（CKD）的基础上由于各种原因所导致的短期内肾小球滤过率迅速下降的一组临床综合征。临床上，CKD患者通常需经历漫长的疾病进展过程。由于疾病本身造成的一...慢性肾脏病基础上的急性肾衰竭（ARF on CKD或A／C）是指患者在原有慢性肾脏病（CKD）的基础上由于各种原因所导致的短期内肾小球滤过率迅速下降的一组临床综合征。临床上，CKD患者通常需经历漫长的疾病进展过程。由于疾病本身造成的一系列机体功能、代谢紊乱及各类并发症使患者随时处于对各种ARF致病因子的易感状态，各类药物的干预也成为影响机体状态的重要因素，因此，展开更多
Increasing evidence has proved that phenotypic changes occured in residential renal cells during the process of renal diseases. The phenotypic change of mesangial cell plays a key role in the development of glomerular...Increasing evidence has proved that phenotypic changes occured in residential renal cells during the process of renal diseases. The phenotypic change of mesangial cell plays a key role in the development of glomerular sclerosis, while the phenotypic changes of tubulo-interstitial cells have close relationship with the progress of interstitial fibrosis. Understandings of these phenotypic changes and their regulations may help us know better of the mechanism of renal diseases and find out ways to block the disease development.展开更多
文摘慢性肾脏病基础上的急性肾衰竭（ARF on CKD或A／C）是指患者在原有慢性肾脏病（CKD）的基础上由于各种原因所导致的短期内肾小球滤过率迅速下降的一组临床综合征。临床上，CKD患者通常需经历漫长的疾病进展过程。由于疾病本身造成的一系列机体功能、代谢紊乱及各类并发症使患者随时处于对各种ARF致病因子的易感状态，各类药物的干预也成为影响机体状态的重要因素，因此，
文摘Increasing evidence has proved that phenotypic changes occured in residential renal cells during the process of renal diseases. The phenotypic change of mesangial cell plays a key role in the development of glomerular sclerosis, while the phenotypic changes of tubulo-interstitial cells have close relationship with the progress of interstitial fibrosis. Understandings of these phenotypic changes and their regulations may help us know better of the mechanism of renal diseases and find out ways to block the disease development.
