目的通过对大多角骨切除联合袢钢板悬吊治疗第一腕掌骨关节炎的随访研究,评价该术式的治疗效果。方法自2018年1月至2020年1月,共纳人第一腕掌骨关节炎患者(Eaton IE期及以上)13例。所有患者均接受大多角骨切除联合袢钢板悬吊术。术后评...目的通过对大多角骨切除联合袢钢板悬吊治疗第一腕掌骨关节炎的随访研究,评价该术式的治疗效果。方法自2018年1月至2020年1月,共纳人第一腕掌骨关节炎患者(Eaton IE期及以上)13例。所有患者均接受大多角骨切除联合袢钢板悬吊术。术后评价治疗效果,客观评价包括捏力、握力、拇指外展角度(掌侧、桡侧)、拇指对掌功能评分(Kapandji评分)和第一掌骨沉降率,主观评价包括视觉模拟疼痛评分(visual analogue scale,VAS)及上肢功能障碍评分(disabilities of the arm,shoulder,and hand questionnaire,DASH)。结果术后13例患者均获得随访,时间为6〜30个月,平均19个月。末次随访时,患者术后疼痛明显缓解,力量明显提高,关节的活动范围及功能明显改善,且结果差异均有统计学意义(P<0.05)。患者术后第一掌骨的高度得到了很好的维持,第一腕掌关节的功能恢复良好,并能返回以前的工作岗位。按照Robbins腕关节评分标准综合评定手术优良率达84.6%。结论大多角骨切除联合袢钢板悬吊术可明显缓解疼痛,改善第一腕掌关节功能,并能在术后维持第一掌骨的高度,疗效确切,值得推广运用。展开更多
Cocrystal has been discovered and studied for more than 170 years since 1844, while the applications to optoelectronics only begin in the last decade. Several general questions that chemists and materials scientists c...Cocrystal has been discovered and studied for more than 170 years since 1844, while the applications to optoelectronics only begin in the last decade. Several general questions that chemists and materials scientists currently seek to answer are: can we design and control the molecular self-assembly and cocrystal growth, what’s the packing-property correlations, as well as how can we improve device parameters for real applications in industry. In this contribution, we review our and other groups’ recent advances in the cocrystal research field sequentially including:(1) nucleation and growth mechanisms for selective preparation of cocrystals with different donor/acceptor ratio and morphology;(2) charge transport and electronic devices, particularly field-effect transistor(FET) and photo-response device. We discuss the in-situ single crystal device fabrication method, ambipolar charge transport, and molecular packingcharge separation correlation;(3) photonic and optical property, focusing on optical waveguide, photonic logic computation, and nonlinear optics(NLO). We present unusual optical properties revealed by advanced instruments and general structure-function relations for future study. Importantly, the extensive investigations described herein yield in-depth and detailed understandings of molecular cocrystals,and show that such bi-component material systems together with the developed instrument measurement methodologies have the potential to initiate unconventional electronic and photonic science and technology.展开更多
The nucleation and growth mechanism and polymorph-property correlations in the molecular cocrystal field are widely sought but currently remain unclear. Herein, a new wire-like morphology of phenazine(Phz)-chloranilic...The nucleation and growth mechanism and polymorph-property correlations in the molecular cocrystal field are widely sought but currently remain unclear. Herein, a new wire-like morphology of phenazine(Phz)-chloranilic acid(H2ca) cocrystal(PHC) is demonstrated for the first time, and the self-assembly of Phz and H2ca is controlled to selectively prepare kinetically stable wires and thermodynamically stable plates. Specifically, low precursor concentration is beneficial for one-dimensional(1D) self-assembly along the [010] crystallographic direction, while only supersaturation can trigger 2D self-assembly along the [100] and [010] directions, respectively. This is understandable in terms of the(020) face showing the largest attachment energy(Eatt) and the(002) face possessing the smallest surface energy(Esurf). Moreover, anisotropic Raman spectra related to the mode symmetry and atomic displacements in two types of PHCs are revealed, and the same Raman-active vibrational bands of PHC wire and plate show different polarization responses, which is intrinsically ascribed to their different molecular orientations.Overall, this is the first case that morphologies of cocrystal are precisely tuned with comprehensive investigations of their anisotropic vibrational characteristics.展开更多
文摘目的通过对大多角骨切除联合袢钢板悬吊治疗第一腕掌骨关节炎的随访研究,评价该术式的治疗效果。方法自2018年1月至2020年1月,共纳人第一腕掌骨关节炎患者(Eaton IE期及以上)13例。所有患者均接受大多角骨切除联合袢钢板悬吊术。术后评价治疗效果,客观评价包括捏力、握力、拇指外展角度(掌侧、桡侧)、拇指对掌功能评分(Kapandji评分)和第一掌骨沉降率,主观评价包括视觉模拟疼痛评分(visual analogue scale,VAS)及上肢功能障碍评分(disabilities of the arm,shoulder,and hand questionnaire,DASH)。结果术后13例患者均获得随访,时间为6〜30个月,平均19个月。末次随访时,患者术后疼痛明显缓解,力量明显提高,关节的活动范围及功能明显改善,且结果差异均有统计学意义(P<0.05)。患者术后第一掌骨的高度得到了很好的维持,第一腕掌关节的功能恢复良好,并能返回以前的工作岗位。按照Robbins腕关节评分标准综合评定手术优良率达84.6%。结论大多角骨切除联合袢钢板悬吊术可明显缓解疼痛,改善第一腕掌关节功能,并能在术后维持第一掌骨的高度,疗效确切,值得推广运用。
基金This work was supported by the National Key R&D Program(2017YFA0204503,2016YFB0401100)the National Natural Science Foundation of China(91833306,21875158,51633006,51703159,and 51733004)。
文摘Cocrystal has been discovered and studied for more than 170 years since 1844, while the applications to optoelectronics only begin in the last decade. Several general questions that chemists and materials scientists currently seek to answer are: can we design and control the molecular self-assembly and cocrystal growth, what’s the packing-property correlations, as well as how can we improve device parameters for real applications in industry. In this contribution, we review our and other groups’ recent advances in the cocrystal research field sequentially including:(1) nucleation and growth mechanisms for selective preparation of cocrystals with different donor/acceptor ratio and morphology;(2) charge transport and electronic devices, particularly field-effect transistor(FET) and photo-response device. We discuss the in-situ single crystal device fabrication method, ambipolar charge transport, and molecular packingcharge separation correlation;(3) photonic and optical property, focusing on optical waveguide, photonic logic computation, and nonlinear optics(NLO). We present unusual optical properties revealed by advanced instruments and general structure-function relations for future study. Importantly, the extensive investigations described herein yield in-depth and detailed understandings of molecular cocrystals,and show that such bi-component material systems together with the developed instrument measurement methodologies have the potential to initiate unconventional electronic and photonic science and technology.
基金supported by the National Natural Science Foundation of China (51303185, 21021091, 51033006, 51222306, 51003107, 61201105, 3591027043, 91222203, 91233205, 21473222 and 21773040)the Ministry of Science and Technology of China (2011CB808400, 2011CB932300, 2013CB933403, 2013CB933500 and 2014CB643600)the Chinese Academy of Sciences (Y42D0A12D1 and Y42D0412D1)。
文摘The nucleation and growth mechanism and polymorph-property correlations in the molecular cocrystal field are widely sought but currently remain unclear. Herein, a new wire-like morphology of phenazine(Phz)-chloranilic acid(H2ca) cocrystal(PHC) is demonstrated for the first time, and the self-assembly of Phz and H2ca is controlled to selectively prepare kinetically stable wires and thermodynamically stable plates. Specifically, low precursor concentration is beneficial for one-dimensional(1D) self-assembly along the [010] crystallographic direction, while only supersaturation can trigger 2D self-assembly along the [100] and [010] directions, respectively. This is understandable in terms of the(020) face showing the largest attachment energy(Eatt) and the(002) face possessing the smallest surface energy(Esurf). Moreover, anisotropic Raman spectra related to the mode symmetry and atomic displacements in two types of PHCs are revealed, and the same Raman-active vibrational bands of PHC wire and plate show different polarization responses, which is intrinsically ascribed to their different molecular orientations.Overall, this is the first case that morphologies of cocrystal are precisely tuned with comprehensive investigations of their anisotropic vibrational characteristics.
