目的:了解国内抗感染药物不良反应(adverse drug reactions,ADR)的发生情况。方法:通过国家人口与健康科学数据共享平台的2 355例ADR报告,基于不良事件本体(ontology of adverse events,OAE),利用文本处理语言perl编程进行数据处理,分析...目的:了解国内抗感染药物不良反应(adverse drug reactions,ADR)的发生情况。方法:通过国家人口与健康科学数据共享平台的2 355例ADR报告,基于不良事件本体(ontology of adverse events,OAE),利用文本处理语言perl编程进行数据处理,分析ADR报告中患者的性别年龄分布、给药途径、药物种类与构成比、发生最多的不良反应、严重不良反应信息。结果:在所有病例报告中,男女例数相当,30~40岁的例数最多,占18.76%,中药引起10岁以下患儿ADR例数最多,占23.81%,引起ADR最多的给药途径是静脉滴注,药物类别是喹诺酮类,最常见的ADR症状是胸闷。结论:基于本体的方法可以有效地分析不良反应。另外,应对抗感染药物ADR引起足够重视,加强抗感染药物ADR监测,促进抗感染药物合理应用。展开更多
Flexoelectric effect, referring to the strain gradient induced polarization, widely exists in dielectric materials, but its molecular dynamics has not been studied so much so far. In this work, the radial distribution...Flexoelectric effect, referring to the strain gradient induced polarization, widely exists in dielectric materials, but its molecular dynamics has not been studied so much so far. In this work, the radial distribution function of BaTiO_(3) and the phase transition temperatures have been investigated, and the results show that the core-shell potential model is effective and the structure of BaTiO_(3) is stable in a temperature range of 10 K–150 K. Molecular dynamics simulated hysteresis loops of BaTiO_(3) show that anisotropy can play an important role in the coercive field. Based on the rational simulation process,the effects of cantilever beam bent angle and fixed length on the polarization are analyzed. It is found that the small bent angle of the curved cantilever beam can give a proportional relationship with a fixed end length and a non-linear relationship is presented when the bent angle is much larger. The prediction of flexoelectric coefficient in BaTiO_(3) is 18.5 nC/m. This work provides a computational framework for the study of flexoelectric effect by using molecular dynamics.展开更多
文摘目的:了解国内抗感染药物不良反应(adverse drug reactions,ADR)的发生情况。方法:通过国家人口与健康科学数据共享平台的2 355例ADR报告,基于不良事件本体(ontology of adverse events,OAE),利用文本处理语言perl编程进行数据处理,分析ADR报告中患者的性别年龄分布、给药途径、药物种类与构成比、发生最多的不良反应、严重不良反应信息。结果:在所有病例报告中,男女例数相当,30~40岁的例数最多,占18.76%,中药引起10岁以下患儿ADR例数最多,占23.81%,引起ADR最多的给药途径是静脉滴注,药物类别是喹诺酮类,最常见的ADR症状是胸闷。结论:基于本体的方法可以有效地分析不良反应。另外,应对抗感染药物ADR引起足够重视,加强抗感染药物ADR监测,促进抗感染药物合理应用。
基金Project supported by the Natural Science Funds of Ningxia,China (Grant No.ZR1221)the National Natural Science Foundation of China (Grant No.11964027)。
文摘Flexoelectric effect, referring to the strain gradient induced polarization, widely exists in dielectric materials, but its molecular dynamics has not been studied so much so far. In this work, the radial distribution function of BaTiO_(3) and the phase transition temperatures have been investigated, and the results show that the core-shell potential model is effective and the structure of BaTiO_(3) is stable in a temperature range of 10 K–150 K. Molecular dynamics simulated hysteresis loops of BaTiO_(3) show that anisotropy can play an important role in the coercive field. Based on the rational simulation process,the effects of cantilever beam bent angle and fixed length on the polarization are analyzed. It is found that the small bent angle of the curved cantilever beam can give a proportional relationship with a fixed end length and a non-linear relationship is presented when the bent angle is much larger. The prediction of flexoelectric coefficient in BaTiO_(3) is 18.5 nC/m. This work provides a computational framework for the study of flexoelectric effect by using molecular dynamics.
