The study on the interaction of cisplatin with guanosine in neutral solution by 13C NMR spectroscopy has shown that besides the formation of [Pt（NH3）2（N7-Guo）2]2+, a new 1:1 complex [Pt（NH3）2(N7.N1-GuoH-1)]nn+, ...The study on the interaction of cisplatin with guanosine in neutral solution by 13C NMR spectroscopy has shown that besides the formation of [Pt（NH3）2（N7-Guo）2]2+, a new 1:1 complex [Pt（NH3）2(N7.N1-GuoH-1)]nn+, in which deprotonated guanosine was bonded to platium by N1 and N7 atoms, was also formed. Recently we have succeed-展开更多
Ⅰ. INTRODUCTION Since it was discovered that cis-platin inhibited the cell division of E. coli and possessed antitumour activity, much study has been made on the relationship between the structure and the antitumour ...Ⅰ. INTRODUCTION Since it was discovered that cis-platin inhibited the cell division of E. coli and possessed antitumour activity, much study has been made on the relationship between the structure and the antitumour function of the platinum complexes. It was found that the cis-configuration of diacidato diammino platinum complexes possessed antitumour activity, but the trans-isomers did not, showing the dependence of展开更多
文摘The study on the interaction of cisplatin with guanosine in neutral solution by 13C NMR spectroscopy has shown that besides the formation of [Pt（NH3）2（N7-Guo）2]2+, a new 1:1 complex [Pt（NH3）2(N7.N1-GuoH-1)]nn+, in which deprotonated guanosine was bonded to platium by N1 and N7 atoms, was also formed. Recently we have succeed-
文摘Ⅰ. INTRODUCTION Since it was discovered that cis-platin inhibited the cell division of E. coli and possessed antitumour activity, much study has been made on the relationship between the structure and the antitumour function of the platinum complexes. It was found that the cis-configuration of diacidato diammino platinum complexes possessed antitumour activity, but the trans-isomers did not, showing the dependence of
