[目的]系统评价联合检测血清肿瘤标志物（CA724、CA199、CEA）对胃癌的诊断价值。[方法]计算机检索Pub Med、中国知网、万方、维普等数据库,收集关于CA724、CA199、CEA在胃癌诊断中应用的相关文献。采用Meta-Disc l.4、Rev Man 5.2和Sta...[目的]系统评价联合检测血清肿瘤标志物（CA724、CA199、CEA）对胃癌的诊断价值。[方法]计算机检索Pub Med、中国知网、万方、维普等数据库,收集关于CA724、CA199、CEA在胃癌诊断中应用的相关文献。采用Meta-Disc l.4、Rev Man 5.2和Stata 13.0进行Meta分析。[结果]纳入10篇文献,共1642例。对胃癌诊断中,单独检测CA724的敏感度为0.49（95%CI：0.45~0.53）,特异度为0.91（95%CI：0.89~0.93）,诊断比值比为10.97（95%CI：8.22~14.63）;联合检测的敏感度为0.76（95%CI：0.73~0.79）,特异度为0.82（95%CI：0.79~0.84）,诊断比值比为19.85（95%CI：10.78~36.52）。单独检测CA724的曲线下面积（AUC）=0.80,Q＊=0.74;联合检测的AUC=0.95,Q＊=0.90。联合检测和单独检测CA724两种方式的诊断效能差异具有统计学意义（Z=4.86,P〈0.05）。[结论]CA724联合检测的诊断效能比单独检测CA724要高,对胃癌的辅助诊断具有较高的指导意义。展开更多
目的评价中药健脾益肾法治疗化疗后白细胞减少症的疗效及安全性。方法计算机检索重庆维普全文数据库、中国知网、万方数据库、Sino Med中国生物医学文献数据库、Pubm Med、Web of Science、EMBASE中关于中药健脾益肾法治疗化疗后白细胞...目的评价中药健脾益肾法治疗化疗后白细胞减少症的疗效及安全性。方法计算机检索重庆维普全文数据库、中国知网、万方数据库、Sino Med中国生物医学文献数据库、Pubm Med、Web of Science、EMBASE中关于中药健脾益肾法治疗化疗后白细胞减少症的临床研究文献,检索日期2000年1月至2016年5月。利用revman5.2、stata11软件进行Meta分析。结果共纳入24篇随机对照试验,合计2369例患者。Meta分析显示,中药健脾益肾法治疗化疗后白细胞减少症在总有效率(RR=1.28,95%CI[1.18,1.39],Z=5.73,P<0.001)与显效率(RR=1.65,95%CI[1.36,1.99],Z=5.11,P<0.001)方面均高于常规服用升白细胞药物组。结论采用中药健脾益肾法治疗化疗后白细胞减少症的总有效率和显效率明显高于常规服用升白药物组,但证据质量不高,仍需要更多大样本、多中心、高质量的随机对照试验进行验证。展开更多
Objective To systematically evaluate the protection effect of electroacupuncture at ＂Neiguan＂（内关 PC 6） on myocardial damage by means of evidence-based medicine.Methods Databases were retrieved by computer,while ...Objective To systematically evaluate the protection effect of electroacupuncture at ＂Neiguan＂（内关 PC 6） on myocardial damage by means of evidence-based medicine.Methods Databases were retrieved by computer,while dissertation compilations and conference proceedings were searched manually.Data were analyzed statistically by using RevMan5.2software.Results Twelve studies were enrolled.Compared with myocardial ischemia reperfusion injury model group,① the magnitude of ECG STⅡ segment elevation can be reduced by means of electroacupuncture at PC 6（WMD=-73.95,95%CI[-109.69,-38.20]） and the difference was statistically significant（P0.0001）;② the ATPase in myocardial cells can be increased by means of electroacupuncture at PC 6（SMD=2.28,95%Cl[1.50,3.07]） and the difference was statistically significant（P0.00001）;③ the release of cTnT can be reduced by means of electroacupuncture at PC 6（WMD=-2.69,95%CI[-3.16,-2.22]） and the difference was statistically significant（P0.00001）;④ the size of myocardial infarction can be reduced by means of electroacupuncture at PC 6（WMD=-17.99,95%Cl[-19.88,-16.09]） and the difference was statistically significant（P0.00001）;⑤ the release of CK can be reduced by means of electroacupuncture at PC 6（WMD=-0.44,95%CI[-0.61,-0.27]） and the difference was statistically significant（P0.00001）;⑥ the release of CK-MB can be reduced by means of electroacupuncture at PC 6（SMD=-2.85,95%CI[-4.46,-1.24]） and the difference was statistically significant（P0.001）;⑦ the release of LDH can be reduced by means of electroacupuncture at PC 6（SMD=-2.97,95%CI[-4.87,-1.07]） and the difference was statistically significant（P0.01）.Conclusion Based on the current experimental evidences,electroacupuncture at PC 6 has a higher protective effect on myocardium.展开更多
目的 探讨他汀的不同种类、服药时间与乳腺癌预后的关系.方法 我们检索了MEDLINE、EMBASE、Cochrane Library、ISI Web of Knowledge等数据库.检索词为breast neoplasms[Mesh]、statins或lipid-lowering drug、prognosis或survival或mor...目的 探讨他汀的不同种类、服药时间与乳腺癌预后的关系.方法 我们检索了MEDLINE、EMBASE、Cochrane Library、ISI Web of Knowledge等数据库.检索词为breast neoplasms[Mesh]、statins或lipid-lowering drug、prognosis或survival或mortality或outcome等,发表时间不限.经过2位作者交叉互查后,使用Stata 11.0软件进行分析.结果 初筛69篇文章,最终入选6篇文章,共纳入196823例女性.总体而言,他汀可以改善乳腺癌的肿瘤特异性死亡及全因死亡率,但其保护作用受限于他汀的种类以及使用时间.脂溶性他汀可以改善乳腺癌的肿瘤特异性死亡及全因死亡率,水溶性他汀能轻微改善全因死亡率,但并不能改善肿瘤特异性死亡率.另外值得关注的是,服用他汀类药物超过4年的亚组并没有见到相关获益.结论 他汀类药物可以改善乳腺癌的预后,但是其保护作用与他汀的种类和服用时间相关.但部分结论与目前的普遍认识不同,还需要进一步的探讨.展开更多
一项美国研究发现，很多癌症患者在临床治愈后仍然长期饱受癌症及治疗所带来的身心折磨。奥兰多佛罗里迭大学（University of Central Florida in Orlando）的Mary Ann Burg和同事们查看了美国癌症协会（American Cancer Society）的一...一项美国研究发现，很多癌症患者在临床治愈后仍然长期饱受癌症及治疗所带来的身心折磨。奥兰多佛罗里迭大学（University of Central Florida in Orlando）的Mary Ann Burg和同事们查看了美国癌症协会（American Cancer Society）的一份涉及1514名癌症生存者的调查研究，评估这些生存者未被满足的需求。展开更多
英国伦敦Hammersmith医院的医生报道了英国首例新生儿器官捐献。在Archives of Disease in Childhood Fetal and Neonatal Edition中1，医生报道了一例只有6天大的女婴在心脏停止跳动后，医生将其肾脏和肝细胞移植给其他两名患者。捐献...英国伦敦Hammersmith医院的医生报道了英国首例新生儿器官捐献。在Archives of Disease in Childhood Fetal and Neonatal Edition中1，医生报道了一例只有6天大的女婴在心脏停止跳动后，医生将其肾脏和肝细胞移植给其他两名患者。捐献者是一个在英国伦敦Hammersmith医院的新生儿病房紧急剖宫产后出生的足月女婴。展开更多
文摘目的评价中药健脾益肾法治疗化疗后白细胞减少症的疗效及安全性。方法计算机检索重庆维普全文数据库、中国知网、万方数据库、Sino Med中国生物医学文献数据库、Pubm Med、Web of Science、EMBASE中关于中药健脾益肾法治疗化疗后白细胞减少症的临床研究文献,检索日期2000年1月至2016年5月。利用revman5.2、stata11软件进行Meta分析。结果共纳入24篇随机对照试验,合计2369例患者。Meta分析显示,中药健脾益肾法治疗化疗后白细胞减少症在总有效率(RR=1.28,95%CI[1.18,1.39],Z=5.73,P<0.001)与显效率(RR=1.65,95%CI[1.36,1.99],Z=5.11,P<0.001)方面均高于常规服用升白细胞药物组。结论采用中药健脾益肾法治疗化疗后白细胞减少症的总有效率和显效率明显高于常规服用升白药物组,但证据质量不高,仍需要更多大样本、多中心、高质量的随机对照试验进行验证。
基金Supported by Natural Science Foundation of China:81403460Hubei Provincial Education and Science"The 12th Five-Year Plan"Project:2014B095
文摘Objective To systematically evaluate the protection effect of electroacupuncture at ＂Neiguan＂（内关 PC 6） on myocardial damage by means of evidence-based medicine.Methods Databases were retrieved by computer,while dissertation compilations and conference proceedings were searched manually.Data were analyzed statistically by using RevMan5.2software.Results Twelve studies were enrolled.Compared with myocardial ischemia reperfusion injury model group,① the magnitude of ECG STⅡ segment elevation can be reduced by means of electroacupuncture at PC 6（WMD=-73.95,95%CI[-109.69,-38.20]） and the difference was statistically significant（P0.0001）;② the ATPase in myocardial cells can be increased by means of electroacupuncture at PC 6（SMD=2.28,95%Cl[1.50,3.07]） and the difference was statistically significant（P0.00001）;③ the release of cTnT can be reduced by means of electroacupuncture at PC 6（WMD=-2.69,95%CI[-3.16,-2.22]） and the difference was statistically significant（P0.00001）;④ the size of myocardial infarction can be reduced by means of electroacupuncture at PC 6（WMD=-17.99,95%Cl[-19.88,-16.09]） and the difference was statistically significant（P0.00001）;⑤ the release of CK can be reduced by means of electroacupuncture at PC 6（WMD=-0.44,95%CI[-0.61,-0.27]） and the difference was statistically significant（P0.00001）;⑥ the release of CK-MB can be reduced by means of electroacupuncture at PC 6（SMD=-2.85,95%CI[-4.46,-1.24]） and the difference was statistically significant（P0.001）;⑦ the release of LDH can be reduced by means of electroacupuncture at PC 6（SMD=-2.97,95%CI[-4.87,-1.07]） and the difference was statistically significant（P0.01）.Conclusion Based on the current experimental evidences,electroacupuncture at PC 6 has a higher protective effect on myocardium.
文摘一项美国研究发现，很多癌症患者在临床治愈后仍然长期饱受癌症及治疗所带来的身心折磨。奥兰多佛罗里迭大学（University of Central Florida in Orlando）的Mary Ann Burg和同事们查看了美国癌症协会（American Cancer Society）的一份涉及1514名癌症生存者的调查研究，评估这些生存者未被满足的需求。
文摘英国伦敦Hammersmith医院的医生报道了英国首例新生儿器官捐献。在Archives of Disease in Childhood Fetal and Neonatal Edition中1，医生报道了一例只有6天大的女婴在心脏停止跳动后，医生将其肾脏和肝细胞移植给其他两名患者。捐献者是一个在英国伦敦Hammersmith医院的新生儿病房紧急剖宫产后出生的足月女婴。
