The effects of Radix Salviae Miltiorrhizae and its component 'DANSHENSU' on the production of PA, PAI, PGI_2 and expression of thrombomodulin by cultured bovine endothelial cells were studied. 6-Keto-PGF_(1α)...The effects of Radix Salviae Miltiorrhizae and its component 'DANSHENSU' on the production of PA, PAI, PGI_2 and expression of thrombomodulin by cultured bovine endothelial cells were studied. 6-Keto-PGF_(1α) was measured with RIA. PA, PAI and thrombomodulin were measured with chromosenic substrate S2390 and S2238 respectively. The results showed that Radix Salviae Miltiorrhizae could promote PA activity and PGI_2 production by bovine endothelial cell (BEC). It could inhibt activity of PAI secreted by BEC. Its component 'DANSHENSU' had the same effects. In addition, Radix Salviae Miltiorrhizae could also increase thrombomodulin activity on the surface of BEC, but 'DANSHENSU' did not.展开更多
文摘The effects of Radix Salviae Miltiorrhizae and its component 'DANSHENSU' on the production of PA, PAI, PGI_2 and expression of thrombomodulin by cultured bovine endothelial cells were studied. 6-Keto-PGF_(1α) was measured with RIA. PA, PAI and thrombomodulin were measured with chromosenic substrate S2390 and S2238 respectively. The results showed that Radix Salviae Miltiorrhizae could promote PA activity and PGI_2 production by bovine endothelial cell (BEC). It could inhibt activity of PAI secreted by BEC. Its component 'DANSHENSU' had the same effects. In addition, Radix Salviae Miltiorrhizae could also increase thrombomodulin activity on the surface of BEC, but 'DANSHENSU' did not.
