Objective To evaluate the effects of both dexamethasone (DXM) and promethazine (PMT) on prevention of the febrile reactions caused by blood transfusion. The remaining 474 patients who did not receive DXM and PTM were...Objective To evaluate the effects of both dexamethasone (DXM) and promethazine (PMT) on prevention of the febrile reactions caused by blood transfusion. The remaining 474 patients who did not receive DXM and PTM were assigned as controls. Methods Statistical analysis was used. 474 out of 948 patients who were given blood transfusion in our hospital were divided into two groups with prophylactic use of drugs administration for 316 patients in DXM group and 158 patients in PMT group. DXM 5 mg (iv) or PTM 25 mg (im) was given for each group before blood transfusion. The remaining 474 patients who did not receive DXM and PTM were assigned as controls. Results The effective rate of DXM in preventing the pyrexial transfusion reaction was 91.14%, compared with 84.39% of the control group, (P<0.01). The effective rate of PMT in preventing the febrile reaction of blood transfusion reached 78.48%, compared with 84.39% of the control group, (P>0.05). The comparison between the effective rate of DXM group (91.14%) and that of PMT group (78.48%) showed statistical difference (P< 0.001). Discussion and conclusion Up to now, the exact rate of the responses (fever) of blood transfusion is not clear. It was reported in the foreign literature that febrile reactions of blood transfusion would make up 54% of all the blood transfusion responses, but according to our data, it occurred in 82.16% of the patients. The disagreement might be due to different standards for the responses (fever). In our data, the effective rate (91.14%) for DXM in preventing the febrile reactions in blood transfusion is higher than that of hydrocortisone (86.30%), which has been reported in the literature. This shows that the prophylactic effect of DXM is better than hydrocortisone. DXM 10 mg (administration dose for 2 units of fresh blood) will not produce other side effects such as hemorrhagic tendency. Therefore DXM is much safer even if it is administered to a hemorrhagic patient. DXM produces effects after it is hydrogenated, so it 展开更多
文摘Objective To evaluate the effects of both dexamethasone (DXM) and promethazine (PMT) on prevention of the febrile reactions caused by blood transfusion. The remaining 474 patients who did not receive DXM and PTM were assigned as controls. Methods Statistical analysis was used. 474 out of 948 patients who were given blood transfusion in our hospital were divided into two groups with prophylactic use of drugs administration for 316 patients in DXM group and 158 patients in PMT group. DXM 5 mg (iv) or PTM 25 mg (im) was given for each group before blood transfusion. The remaining 474 patients who did not receive DXM and PTM were assigned as controls. Results The effective rate of DXM in preventing the pyrexial transfusion reaction was 91.14%, compared with 84.39% of the control group, (P<0.01). The effective rate of PMT in preventing the febrile reaction of blood transfusion reached 78.48%, compared with 84.39% of the control group, (P>0.05). The comparison between the effective rate of DXM group (91.14%) and that of PMT group (78.48%) showed statistical difference (P< 0.001). Discussion and conclusion Up to now, the exact rate of the responses (fever) of blood transfusion is not clear. It was reported in the foreign literature that febrile reactions of blood transfusion would make up 54% of all the blood transfusion responses, but according to our data, it occurred in 82.16% of the patients. The disagreement might be due to different standards for the responses (fever). In our data, the effective rate (91.14%) for DXM in preventing the febrile reactions in blood transfusion is higher than that of hydrocortisone (86.30%), which has been reported in the literature. This shows that the prophylactic effect of DXM is better than hydrocortisone. DXM 10 mg (administration dose for 2 units of fresh blood) will not produce other side effects such as hemorrhagic tendency. Therefore DXM is much safer even if it is administered to a hemorrhagic patient. DXM produces effects after it is hydrogenated, so it
