龙胆Gentianae Radix et Rhizoma具有清热燥湿、泻肝胆火的功效。龙胆主要含有环烯醚萜类、三萜类、[口山]酮类及黄酮类等化学成分,具有抗炎镇痛、保肝、抗肿瘤、调节胃肠功能、调节神经系统等作用,临床上广泛应用于带状疱疹、高血压、...龙胆Gentianae Radix et Rhizoma具有清热燥湿、泻肝胆火的功效。龙胆主要含有环烯醚萜类、三萜类、[口山]酮类及黄酮类等化学成分,具有抗炎镇痛、保肝、抗肿瘤、调节胃肠功能、调节神经系统等作用,临床上广泛应用于带状疱疹、高血压、突发性耳聋及各类炎症性疾病。通过对龙胆的化学成分、生物活性和临床应用进行综述,为其进一步开发和应用提供理论参考和科学依据。展开更多
This study is intended to explore the chemical differences of Acori Tatarinowii Rhizoma （ATR） samples collected from two habitats, Sichuan and Anhui provinces, China. Gas chromatography-mass spectrometry （GC-MS） w...This study is intended to explore the chemical differences of Acori Tatarinowii Rhizoma （ATR） samples collected from two habitats, Sichuan and Anhui provinces, China. Gas chromatography-mass spectrometry （GC-MS） was applied to establishing the quantitative chemical fingerprints of ATRs. A total of 104 volatile compounds were identified and quantified with the information of mass spectra and retention index （RI）. Furthermore, least absolute shrinkage and selection operator （LASSO）, a sparse regularization method, combined with subsampling was employed to improve the classification ability of partial least squares-discriminant analysis （PLS-DA）. After variable selection by LASSO, three chemical markers,β-elemene, α-selinene and α-asarone, were identified for the discrimination of ATRs from two habitats, and the total classification correct rate was increased from 82.76% to 96.55%. The proposed LASSO-PLS-DA method can serve as an efficient strategy for screening marked chemical components and geo-herbalism research of traditional Chinese medicines.展开更多
为研究中高应变率下NRP和掺高粘剂的SBS两种改性剂对AC-13型沥青混凝土动力性能的影响,采用直径74 mm SHPB装置进行了4个气压下的冲击压缩试验,获得了不同种类改性沥青混凝土的破坏形态及应力-应变曲线。研究表明:沥青混凝土动态应力-...为研究中高应变率下NRP和掺高粘剂的SBS两种改性剂对AC-13型沥青混凝土动力性能的影响,采用直径74 mm SHPB装置进行了4个气压下的冲击压缩试验,获得了不同种类改性沥青混凝土的破坏形态及应力-应变曲线。研究表明:沥青混凝土动态应力-应变曲线分为弹性变形、塑性强化和塑性破坏3个阶段,破坏形态分为裂缝、破损、块裂和碎裂4种;两种改性剂均能改善沥青混凝土的抗冲击性能,并且对峰值应力和冲击韧性的应变率敏感性有一定影响,在不同应变率范围内两种改性剂对冲击韧性增强作用不同,NRP对峰值应力增强作用优于掺高粘剂的SBS;应变率超过130/s时,沥青混凝土出现弹性模量退化现象,NRP对弹性模量有提高作用。展开更多
文摘龙胆Gentianae Radix et Rhizoma具有清热燥湿、泻肝胆火的功效。龙胆主要含有环烯醚萜类、三萜类、[口山]酮类及黄酮类等化学成分,具有抗炎镇痛、保肝、抗肿瘤、调节胃肠功能、调节神经系统等作用,临床上广泛应用于带状疱疹、高血压、突发性耳聋及各类炎症性疾病。通过对龙胆的化学成分、生物活性和临床应用进行综述,为其进一步开发和应用提供理论参考和科学依据。
基金Project(21465016)supported by the National Natural Foundation of China
文摘This study is intended to explore the chemical differences of Acori Tatarinowii Rhizoma （ATR） samples collected from two habitats, Sichuan and Anhui provinces, China. Gas chromatography-mass spectrometry （GC-MS） was applied to establishing the quantitative chemical fingerprints of ATRs. A total of 104 volatile compounds were identified and quantified with the information of mass spectra and retention index （RI）. Furthermore, least absolute shrinkage and selection operator （LASSO）, a sparse regularization method, combined with subsampling was employed to improve the classification ability of partial least squares-discriminant analysis （PLS-DA）. After variable selection by LASSO, three chemical markers,β-elemene, α-selinene and α-asarone, were identified for the discrimination of ATRs from two habitats, and the total classification correct rate was increased from 82.76% to 96.55%. The proposed LASSO-PLS-DA method can serve as an efficient strategy for screening marked chemical components and geo-herbalism research of traditional Chinese medicines.
基金中南民族大学教学研究项目“以任务为导向虚实相结合的电工电子实验教学模式的研究与探索”(编号:JYX20120)中南民族大学教学研究项目“新工科背景下面向工程教育的实验教学研究与探索”(编号:JYX19115)中央高校基本科研业务费专项资金项目“基于NI ELVIS Ⅲ的虚实融合云服务实验系统研究与设计”(编号:CZQ20019)
文摘为研究中高应变率下NRP和掺高粘剂的SBS两种改性剂对AC-13型沥青混凝土动力性能的影响,采用直径74 mm SHPB装置进行了4个气压下的冲击压缩试验,获得了不同种类改性沥青混凝土的破坏形态及应力-应变曲线。研究表明:沥青混凝土动态应力-应变曲线分为弹性变形、塑性强化和塑性破坏3个阶段,破坏形态分为裂缝、破损、块裂和碎裂4种;两种改性剂均能改善沥青混凝土的抗冲击性能,并且对峰值应力和冲击韧性的应变率敏感性有一定影响,在不同应变率范围内两种改性剂对冲击韧性增强作用不同,NRP对峰值应力增强作用优于掺高粘剂的SBS;应变率超过130/s时,沥青混凝土出现弹性模量退化现象,NRP对弹性模量有提高作用。
