Background The infarct size determines the long-term prognosis of patients with acute myocardial infarction (AMI). There is a growing interest in repairing scar area by transplanting bone marrow stem cells. However, ...Background The infarct size determines the long-term prognosis of patients with acute myocardial infarction (AMI). There is a growing interest in repairing scar area by transplanting bone marrow stem cells. However, effectiveness of intracoronary injection of bone marrow mesenchymal stem cells (BMSCs) in patients with AMI still remains unclear.Methods Sixty-nine patients with AMI after percutaneous coronary intervention (PCI) were randomly divided into intracoronary injection of BMSCs (n=34) and saline (control group, n=35) groups. Serial single positron emission computer tomography (SPECT), cardiac echo and cardiac electromechanical mapping were done at the designed time intervals until six months after transplantation of BMSCs or injection of saline. Results The proportion with functional defect decreased significantly in the BMSCs patients after three months [(13±5)%] compared with that pre-transplantation [(32±11)%] and the control group [(28±10)%] at three month follow-up (P<0.05, respectively). Wall movement velocity over the infracted region increased significantly in the BMSCs group [(4.2±2.5) cm/s vs (2.2±1.3) cm/s, P<0.05], but not in the control group [(2.2±1.5) cm/s vs (2.7±1.7) cm/s, P>0.05]. Left ventricular ejection fraction (LVEF) three months after transplantation in BMSCs group increased significantly compared with that pre-implantation and with that of the control group at three months post-injection [(67±11)% vs (49±9)% and (53±8)%, P<0.05 respectively]. SPECT scan results showed that perfusion defect was improved significantly in BMSCs group at three-month follow-up compared with that in the control group [(134±66)cm2 vs (185±87)cm2, P<0.01]. At the same time, left ventricular end-diastolic volume [(136±31) ml vs (162±27) ml, P<0.05] and end-systolic volume [(63±20) ml vs (88±19) ml, P<0.05] decreased synchronously. The ratio of end-systolic pressure to end-systolic volume [P_ syst/ESV, (2.84±1.30) mmHg/ml vs (1.72±1.23) mmHg/ml, P<0.05] increased significantly. Cardiac展开更多
采用多点试验,对冬油菜在原种植区（天水）与北移种植区（张掖等）的主要气候因子、越冬率、生育时期及经济性状进行分析比较。研究结果表明,冬油菜北移后越冬率由原种植区的93.0%-100.0%降为40.0%-95.0%;生育期由280-284 d延至287-289...采用多点试验,对冬油菜在原种植区（天水）与北移种植区（张掖等）的主要气候因子、越冬率、生育时期及经济性状进行分析比较。研究结果表明,冬油菜北移后越冬率由原种植区的93.0%-100.0%降为40.0%-95.0%;生育期由280-284 d延至287-289 d,其冬前与冬后生长期缩短,而越冬期延长1倍左右,即140 d左右,整个生长期呈＂短-长-短＂的特点,即营养生长有效期缩短及营养生长至生殖生长的过渡期均缩短;株高与分枝部位降低,分枝数减少,单株角果数减少,但千粒重、角粒数等相对增加。冬油菜北移后产量发生了较大变化,抗寒性弱的早熟品种天油8号由原种植区的2 518.8 kg hm^-2降为1 666.5 kg hm^-2,减产34.0%,而抗寒性强的晚熟品种陇油6号等由原种植区的741 kg hm^-2增加到3 333 kg hm^-2,增幅349.5%。由于生长在相对恶劣的气候生态条件下,越冬期漫长而极端低温低,北移冬油菜栽培品种必须具备优异的抗寒性,同时采用合理播期和密度,保证冬前营养生长期和营养生长量,以确保安全越冬。展开更多
文摘Background The infarct size determines the long-term prognosis of patients with acute myocardial infarction (AMI). There is a growing interest in repairing scar area by transplanting bone marrow stem cells. However, effectiveness of intracoronary injection of bone marrow mesenchymal stem cells (BMSCs) in patients with AMI still remains unclear.Methods Sixty-nine patients with AMI after percutaneous coronary intervention (PCI) were randomly divided into intracoronary injection of BMSCs (n=34) and saline (control group, n=35) groups. Serial single positron emission computer tomography (SPECT), cardiac echo and cardiac electromechanical mapping were done at the designed time intervals until six months after transplantation of BMSCs or injection of saline. Results The proportion with functional defect decreased significantly in the BMSCs patients after three months [(13±5)%] compared with that pre-transplantation [(32±11)%] and the control group [(28±10)%] at three month follow-up (P<0.05, respectively). Wall movement velocity over the infracted region increased significantly in the BMSCs group [(4.2±2.5) cm/s vs (2.2±1.3) cm/s, P<0.05], but not in the control group [(2.2±1.5) cm/s vs (2.7±1.7) cm/s, P>0.05]. Left ventricular ejection fraction (LVEF) three months after transplantation in BMSCs group increased significantly compared with that pre-implantation and with that of the control group at three months post-injection [(67±11)% vs (49±9)% and (53±8)%, P<0.05 respectively]. SPECT scan results showed that perfusion defect was improved significantly in BMSCs group at three-month follow-up compared with that in the control group [(134±66)cm2 vs (185±87)cm2, P<0.01]. At the same time, left ventricular end-diastolic volume [(136±31) ml vs (162±27) ml, P<0.05] and end-systolic volume [(63±20) ml vs (88±19) ml, P<0.05] decreased synchronously. The ratio of end-systolic pressure to end-systolic volume [P_ syst/ESV, (2.84±1.30) mmHg/ml vs (1.72±1.23) mmHg/ml, P<0.05] increased significantly. Cardiac
文摘采用多点试验,对冬油菜在原种植区（天水）与北移种植区（张掖等）的主要气候因子、越冬率、生育时期及经济性状进行分析比较。研究结果表明,冬油菜北移后越冬率由原种植区的93.0%-100.0%降为40.0%-95.0%;生育期由280-284 d延至287-289 d,其冬前与冬后生长期缩短,而越冬期延长1倍左右,即140 d左右,整个生长期呈＂短-长-短＂的特点,即营养生长有效期缩短及营养生长至生殖生长的过渡期均缩短;株高与分枝部位降低,分枝数减少,单株角果数减少,但千粒重、角粒数等相对增加。冬油菜北移后产量发生了较大变化,抗寒性弱的早熟品种天油8号由原种植区的2 518.8 kg hm^-2降为1 666.5 kg hm^-2,减产34.0%,而抗寒性强的晚熟品种陇油6号等由原种植区的741 kg hm^-2增加到3 333 kg hm^-2,增幅349.5%。由于生长在相对恶劣的气候生态条件下,越冬期漫长而极端低温低,北移冬油菜栽培品种必须具备优异的抗寒性,同时采用合理播期和密度,保证冬前营养生长期和营养生长量,以确保安全越冬。
