Spermatogenesis is critical for the maintenance of lifelong male fertility, and is characterized by sequential cell fate transition, including spermatogonia self-renewal and differentiation, meiosis, and finally sperm...Spermatogenesis is critical for the maintenance of lifelong male fertility, and is characterized by sequential cell fate transition, including spermatogonia self-renewal and differentiation, meiosis, and finally spermiogenesis to form mature spermatozoa. Recent single-cell analysis studies have revealed novel signatures of spermatogenesis in mice and humans. Although the landscape of germ cells and the regulatory network underlying spermatogenesis in mammals are still debated, a general consensus has been established about the cell composition and key molecular events. This review highlights recent progress in mammalian spermatogenesis research in terms of testicular cell types, developmental trajectory, and regulatory mechanisms.展开更多
基金the National Natural Science Foundation of China(Grant Nos.31671544,31970787 and 81901542).
文摘Spermatogenesis is critical for the maintenance of lifelong male fertility, and is characterized by sequential cell fate transition, including spermatogonia self-renewal and differentiation, meiosis, and finally spermiogenesis to form mature spermatozoa. Recent single-cell analysis studies have revealed novel signatures of spermatogenesis in mice and humans. Although the landscape of germ cells and the regulatory network underlying spermatogenesis in mammals are still debated, a general consensus has been established about the cell composition and key molecular events. This review highlights recent progress in mammalian spermatogenesis research in terms of testicular cell types, developmental trajectory, and regulatory mechanisms.
