基金supported by the National Natural Science Foundation of China (No. 81572859)National Basic Research Development Program of China (No. 2014CB910303)+5 种基金Scientific Fund of Shanghai Commission of Health and Family Planning (No. 201640201 201740027 and 201840003)the Scientific Program of District of Chongming Science and Technology Committee Shanghai Municipality China (No. CKY2016-03 CKZ2015-01 and CKY2018-3)