目的:了解职业苯接触及慢性苯中毒工人外周血中T细胞特异性转录因子T-bet和GATA-3mRNA表达情况。方法:利用SYBR Green I实时荧光定量PCR分别检测20例正常人、25例职业苯接触工人和27例慢性苯中毒工人外周血单个核细胞T-bet和GATA-3 mRN...目的:了解职业苯接触及慢性苯中毒工人外周血中T细胞特异性转录因子T-bet和GATA-3mRNA表达情况。方法:利用SYBR Green I实时荧光定量PCR分别检测20例正常人、25例职业苯接触工人和27例慢性苯中毒工人外周血单个核细胞T-bet和GATA-3 mRNA表达情况。结果:在职业接触苯工人组及慢性苯中毒工人组,多数样本表现为GATA-3表达上升和T-bet表达下降,而少数病人则表现为相反的模式。GATA-3在正常人的表达水平为0.39±0.22,与正常组对照比较职业接触苯工人组中有19例GATA-3表达水平呈上升趋势(0.57±0.54),慢性苯中毒工人组中则有20例GATA-3表达水平呈上升趋势(0.52±0.50)。此外,在职业接触苯工人组中发现6例GATA-3表达水平显著下降(0.15±0.12,P<0.05),同样在慢性苯中毒工人组中也有7例GATA-3表达水平显著下降(0.07±0.06,P<0.05)。T-bet在正常人的表达水平为2.15±1.45,与正常组对照比较职业接触苯工人组中有19例T-bet表达水平呈下降趋势(1.91±1.49),慢性苯中毒工人组中T-bet表达水平均呈下降趋势(1.52±0.56)。此外,在职业接触苯工人组中也可发现6例T-bet表达水平显著上升(3.19±2.10,P<0.05)。结论:职业苯接触及慢性苯中毒影响工人外周血中T细胞特异性转录因子T-bet和GATA-3mRNA表达水平。展开更多
Clinical application of implantable cardioverter defibrillator （ICD） can significantly reduce the incidence of sudden cardiac death （SCD）. However, ICD cannot prevent ventricular tachycardia （VT） or ventricu- la...Clinical application of implantable cardioverter defibrillator （ICD） can significantly reduce the incidence of sudden cardiac death （SCD）. However, ICD cannot prevent ventricular tachycardia （VT） or ventricu- lar fibrillation （VF）. Previous studies indicated that ICD combined with reasonable anti-arrhytbmic drug therapy can improve anti-arrhythmic effect. EMIAT, CAMIA and OPTIC trials reported that combined treatment of Ami- odarone and β receptor blockers was superior to their treatment alone. Therefore, it is necessary to give anti-at- rhythmic treatment alter 1CD implantation. Methods Totally 180 ICD implantation recipients enrolled in our hospital from Jan 2011 to March 2014. Among them, 39 recipients were treated with Amiodarone （Group A）, 89 recipients were treated with β blocker （Group B）, and 52 recipients were treated with Amiodarone combined with β blocker （Group C） after ICD implantation. Patients were followed up for 3 to 40 months by monitoring the heart rate, LVEF Value and rapid ventricular arrhythmias events. Results There were no significant differences on heart rate before and after ICD implantation among the three groups （P = 1.28, P = 0.85）, but the change of heart rate was statistically higher （P = 0.04） in Group B compared with Group A and Group C. There were no sta- tistical significance in LVEF value before ICD implantation and after ICD implantation and the change of LVEF value （P = 0.56, P = 0.50, P = 0,99）. The occurrence rate of rapid ventricular arrhythmias in Group A （10.26%） and Group B （10.11%） was significantly higher （P = 0.04） than in Group C （1.92%）. which wae slight- ly increased by Amiodarone in Group A and Group C. There were 2 cases of thyroid dysfunction in Group A, 1 case in Group C and no case in Group B. No pulmonary interstitial fibrosis cases were found in this study. Conclusions Combined treatment with Amiodarone and β receptor blockers could significantly reduce rapid ven- tricular arrhythmias when compared展开更多
Background Non-high-density lipoprotein cholesterol （non-HDL-C） and Apolipoprotein B （apoB） increase car- diovascular disease （CVD） risk, but few studies have explored the correlations of non-HDL-C and apoB with...Background Non-high-density lipoprotein cholesterol （non-HDL-C） and Apolipoprotein B （apoB） increase car- diovascular disease （CVD） risk, but few studies have explored the correlations of non-HDL-C and apoB with cor- onary atherosclerosis in non-diabetes acute coronary syndrome （ACS）. Methods The study enrolled 443 sub- jects with non-diabetic ACS, and all subject check coronary angiography, and coronary atherosclerosis were eval- uated using Gensini Score （GS） scale including small （GS 1-15）, middle （GS16-43）, and severe （GS≥44）. All sub- jects were classified into 4 groups： High apoB （≥90 mg/dL） and High non-HDL-C （≥130 mg/dL）, High non-HDL -C alone, High apoB alone, and normal apoB and non-HDL-C. Results After adjusted for risk factors, non-HDL -C and apoB were positively correlated with GS （ r = 0.075, P = 0.002 and r = 0.092, P 〈 0.001）. In the GS 0-15, high non-HDL-C ＋ high apoB group 29.3% and high apoB alone group 28.2% were significantly lower than nor- mal non-HDL-C＋ normal apoB group 48% （p = 0.010）. In the GS 16-43, high non-HDL-C alone group 50.4% and high apoB alone group 47.6% were significantly more than high non-HDL-C＋ high apoB group 34.1% （P = 0.036）. In the GS ≥44, high non-HDL-C＋ high apoB group 36.6% was significantly higher than high non-HDL- C alone group 16% and normal non-HDL-C＋ normal apoB 14.2%（P 〈 0.001）. Conclusions The high non-HDL- C and apoB are the risk factors for coronary artery atherosclerosis in non-diabetic ACS.展开更多
文摘目的:了解职业苯接触及慢性苯中毒工人外周血中T细胞特异性转录因子T-bet和GATA-3mRNA表达情况。方法:利用SYBR Green I实时荧光定量PCR分别检测20例正常人、25例职业苯接触工人和27例慢性苯中毒工人外周血单个核细胞T-bet和GATA-3 mRNA表达情况。结果:在职业接触苯工人组及慢性苯中毒工人组,多数样本表现为GATA-3表达上升和T-bet表达下降,而少数病人则表现为相反的模式。GATA-3在正常人的表达水平为0.39±0.22,与正常组对照比较职业接触苯工人组中有19例GATA-3表达水平呈上升趋势(0.57±0.54),慢性苯中毒工人组中则有20例GATA-3表达水平呈上升趋势(0.52±0.50)。此外,在职业接触苯工人组中发现6例GATA-3表达水平显著下降(0.15±0.12,P<0.05),同样在慢性苯中毒工人组中也有7例GATA-3表达水平显著下降(0.07±0.06,P<0.05)。T-bet在正常人的表达水平为2.15±1.45,与正常组对照比较职业接触苯工人组中有19例T-bet表达水平呈下降趋势(1.91±1.49),慢性苯中毒工人组中T-bet表达水平均呈下降趋势(1.52±0.56)。此外,在职业接触苯工人组中也可发现6例T-bet表达水平显著上升(3.19±2.10,P<0.05)。结论:职业苯接触及慢性苯中毒影响工人外周血中T细胞特异性转录因子T-bet和GATA-3mRNA表达水平。
基金supported by the Natural Science Foundation of China(No.81070182)the Natural Science Foundation of Guangdong Province(No.10151008901000224)
文摘Clinical application of implantable cardioverter defibrillator （ICD） can significantly reduce the incidence of sudden cardiac death （SCD）. However, ICD cannot prevent ventricular tachycardia （VT） or ventricu- lar fibrillation （VF）. Previous studies indicated that ICD combined with reasonable anti-arrhytbmic drug therapy can improve anti-arrhythmic effect. EMIAT, CAMIA and OPTIC trials reported that combined treatment of Ami- odarone and β receptor blockers was superior to their treatment alone. Therefore, it is necessary to give anti-at- rhythmic treatment alter 1CD implantation. Methods Totally 180 ICD implantation recipients enrolled in our hospital from Jan 2011 to March 2014. Among them, 39 recipients were treated with Amiodarone （Group A）, 89 recipients were treated with β blocker （Group B）, and 52 recipients were treated with Amiodarone combined with β blocker （Group C） after ICD implantation. Patients were followed up for 3 to 40 months by monitoring the heart rate, LVEF Value and rapid ventricular arrhythmias events. Results There were no significant differences on heart rate before and after ICD implantation among the three groups （P = 1.28, P = 0.85）, but the change of heart rate was statistically higher （P = 0.04） in Group B compared with Group A and Group C. There were no sta- tistical significance in LVEF value before ICD implantation and after ICD implantation and the change of LVEF value （P = 0.56, P = 0.50, P = 0,99）. The occurrence rate of rapid ventricular arrhythmias in Group A （10.26%） and Group B （10.11%） was significantly higher （P = 0.04） than in Group C （1.92%）. which wae slight- ly increased by Amiodarone in Group A and Group C. There were 2 cases of thyroid dysfunction in Group A, 1 case in Group C and no case in Group B. No pulmonary interstitial fibrosis cases were found in this study. Conclusions Combined treatment with Amiodarone and β receptor blockers could significantly reduce rapid ven- tricular arrhythmias when compared
基金supported by the Natural Science Foundation of China(No.81070182)the Natural Science Foundation of Guangdong Province(No.10151008901000224)
文摘Background Non-high-density lipoprotein cholesterol （non-HDL-C） and Apolipoprotein B （apoB） increase car- diovascular disease （CVD） risk, but few studies have explored the correlations of non-HDL-C and apoB with cor- onary atherosclerosis in non-diabetes acute coronary syndrome （ACS）. Methods The study enrolled 443 sub- jects with non-diabetic ACS, and all subject check coronary angiography, and coronary atherosclerosis were eval- uated using Gensini Score （GS） scale including small （GS 1-15）, middle （GS16-43）, and severe （GS≥44）. All sub- jects were classified into 4 groups： High apoB （≥90 mg/dL） and High non-HDL-C （≥130 mg/dL）, High non-HDL -C alone, High apoB alone, and normal apoB and non-HDL-C. Results After adjusted for risk factors, non-HDL -C and apoB were positively correlated with GS （ r = 0.075, P = 0.002 and r = 0.092, P 〈 0.001）. In the GS 0-15, high non-HDL-C ＋ high apoB group 29.3% and high apoB alone group 28.2% were significantly lower than nor- mal non-HDL-C＋ normal apoB group 48% （p = 0.010）. In the GS 16-43, high non-HDL-C alone group 50.4% and high apoB alone group 47.6% were significantly more than high non-HDL-C＋ high apoB group 34.1% （P = 0.036）. In the GS ≥44, high non-HDL-C＋ high apoB group 36.6% was significantly higher than high non-HDL- C alone group 16% and normal non-HDL-C＋ normal apoB 14.2%（P 〈 0.001）. Conclusions The high non-HDL- C and apoB are the risk factors for coronary artery atherosclerosis in non-diabetic ACS.
