目的分析门冬胰岛素对妊娠期糖尿病(GDM)患者胰岛细胞分泌功能、超声影像学指标及母婴结局的影响。方法回顾性分析首都医科大学附属北京妇产医院2017年2月至2019年7月120例GDM患者的临床资料。其中,采用门冬胰岛素治疗60例(观察组),采...目的分析门冬胰岛素对妊娠期糖尿病(GDM)患者胰岛细胞分泌功能、超声影像学指标及母婴结局的影响。方法回顾性分析首都医科大学附属北京妇产医院2017年2月至2019年7月120例GDM患者的临床资料。其中,采用门冬胰岛素治疗60例(观察组),采用生物合成人胰岛素治疗60例(对照组)。比较疗效指标、超声影像学指标及母婴结局。结果观察组治疗第3和5天早餐餐后2 h血糖(2 h PBG)明显低于对照组[(6.85±0.87)mmol/L比(7.47±1.35)mmol/L和(6.24±0.59)mmol/L比(6.60±0.87)mmol/L],差异有统计学意义(P<0.01);两组治疗第1天早餐及治疗第1、3和5天中餐和晚餐2 h PBG比较差异均无统计学意义(P>0.05)。观察组治疗后稳态模型评估法胰岛素抵抗指数(HOMA-IR)明显低于对照组(2.57±0.25比3.00±0.35),稳态模型评估法胰岛β细胞功能指数(HOMA-β)明显高于对照组(72.45±12.33比63.66±10.72),差异有统计学意义(P<0.01)。两组中餐前血糖、中餐初始胰岛素量、中餐最终胰岛素量和血糖达标时间比较差异无统计学意义(P>0.05);观察组餐前低血糖事件发生率明显低于对照组[8.33%(5/60)比23.33%(14/60)],差异有统计学意义(P<0.05)。观察组治疗后脐动脉和肾动脉阻力指数(RI)、收缩期最大血流速度与舒张末期血流速度比值(S/D)明显低于对照组(RI:0.49±0.16比0.59±0.15和0.69±0.17比0.76±0.12;S/D:2.09±0.22比2.38±0.26和5.17±0.45比5.77±0.63),差异有统计学意义(P<0.01或<0.05)。两组分娩孕周、分娩方式、新生儿体质量及巨大儿、新生儿低血糖、转新生儿科发生率比较差异均无统计学意义(P>0.05)。结论门冬胰岛素治疗GDM对胰岛细胞分泌功能、超声影像学指标的改善更显著,并能降低餐前低血糖事件发生风险,但对母婴结局的影响仍有待探究。展开更多
Porous chitosan microspheres with diameters ranging from 180μm to 280 μm were successfully prepared, using an anti-phase suspension method combined with temperature controlled freeze-extraction. The mean pore diamet...Porous chitosan microspheres with diameters ranging from 180μm to 280 μm were successfully prepared, using an anti-phase suspension method combined with temperature controlled freeze-extraction. The mean pore diameter could be regulated from 5 μm to 60μm by varying the freezing temperature through the cooling rate. Results with in vitro chondrocyte cultures showed that cells could attach, proliferate and spread on these porous microspheres as well as inside the microcarriers. The materials and cell cocultures were characterized using both optical and scanning electron microscopy. These results show that the porous chitosan microspheres are promising candidates for tissue culture for use as an injectable tissue engineering scaffold.展开更多
文摘目的分析门冬胰岛素对妊娠期糖尿病(GDM)患者胰岛细胞分泌功能、超声影像学指标及母婴结局的影响。方法回顾性分析首都医科大学附属北京妇产医院2017年2月至2019年7月120例GDM患者的临床资料。其中,采用门冬胰岛素治疗60例(观察组),采用生物合成人胰岛素治疗60例(对照组)。比较疗效指标、超声影像学指标及母婴结局。结果观察组治疗第3和5天早餐餐后2 h血糖(2 h PBG)明显低于对照组[(6.85±0.87)mmol/L比(7.47±1.35)mmol/L和(6.24±0.59)mmol/L比(6.60±0.87)mmol/L],差异有统计学意义(P<0.01);两组治疗第1天早餐及治疗第1、3和5天中餐和晚餐2 h PBG比较差异均无统计学意义(P>0.05)。观察组治疗后稳态模型评估法胰岛素抵抗指数(HOMA-IR)明显低于对照组(2.57±0.25比3.00±0.35),稳态模型评估法胰岛β细胞功能指数(HOMA-β)明显高于对照组(72.45±12.33比63.66±10.72),差异有统计学意义(P<0.01)。两组中餐前血糖、中餐初始胰岛素量、中餐最终胰岛素量和血糖达标时间比较差异无统计学意义(P>0.05);观察组餐前低血糖事件发生率明显低于对照组[8.33%(5/60)比23.33%(14/60)],差异有统计学意义(P<0.05)。观察组治疗后脐动脉和肾动脉阻力指数(RI)、收缩期最大血流速度与舒张末期血流速度比值(S/D)明显低于对照组(RI:0.49±0.16比0.59±0.15和0.69±0.17比0.76±0.12;S/D:2.09±0.22比2.38±0.26和5.17±0.45比5.77±0.63),差异有统计学意义(P<0.01或<0.05)。两组分娩孕周、分娩方式、新生儿体质量及巨大儿、新生儿低血糖、转新生儿科发生率比较差异均无统计学意义(P>0.05)。结论门冬胰岛素治疗GDM对胰岛细胞分泌功能、超声影像学指标的改善更显著,并能降低餐前低血糖事件发生风险,但对母婴结局的影响仍有待探究。
基金Supported by the National Key Basic Research and Development (973) Program of China (No. 2005CB623905) and the Tsinghua-Yue-Yuen Medical Science Fund
文摘Porous chitosan microspheres with diameters ranging from 180μm to 280 μm were successfully prepared, using an anti-phase suspension method combined with temperature controlled freeze-extraction. The mean pore diameter could be regulated from 5 μm to 60μm by varying the freezing temperature through the cooling rate. Results with in vitro chondrocyte cultures showed that cells could attach, proliferate and spread on these porous microspheres as well as inside the microcarriers. The materials and cell cocultures were characterized using both optical and scanning electron microscopy. These results show that the porous chitosan microspheres are promising candidates for tissue culture for use as an injectable tissue engineering scaffold.
