We study the propagation properties of a probe field in an aligned asymmetric triple quantum dot molecule with both sides inter-dot tunneling coupling effect. It is shown that the probe field can form optical soliton ...We study the propagation properties of a probe field in an aligned asymmetric triple quantum dot molecule with both sides inter-dot tunneling coupling effect. It is shown that the probe field can form optical soliton due to the destructive quantum interference induced by the quantum inter-dot tunneling coupling effect. Interestingly, these optical solitons can be stored and retrieved by adjusting single or double inter-dot tunneling coupling effect, different from that light memory in the ultra-cold atom system. Furthermore, we also find that the amplitude of the stored optical soliton can be adjusted by the strength of the single or double inter-dot tunneling coupling. It is possible to improve the stability and the fidelity of the optical information in the process of the storage and retrieval in semiconductor quantum dots devices.展开更多
为了探讨泛素样含植物同源结构域和环指结构域1蛋白(ubiquitin-like with PHD and ring finger domains 1,UHRF1)对前列腺癌PC-3细胞生物学功能的影响及相关机制,我们用含有UHRF1和shRNA-UHRF1的慢病毒颗粒分别感染PC-3细胞,构建UHRF1...为了探讨泛素样含植物同源结构域和环指结构域1蛋白(ubiquitin-like with PHD and ring finger domains 1,UHRF1)对前列腺癌PC-3细胞生物学功能的影响及相关机制,我们用含有UHRF1和shRNA-UHRF1的慢病毒颗粒分别感染PC-3细胞,构建UHRF1沉默或过表达的稳转细胞株模型。利用实时荧光定量PCR(RT-qPCR)、蛋白免疫印迹(Western blot)和细胞免疫荧光实验验证感染后UHRF1表达水平和检测UHRF1对DNMT1、p16^(INK4A)的mRNA及蛋白表达水平的影响。CCK-8实验、划痕实验、Transwell实验和流式细胞术实验研究UHRF1对PC-3细胞增殖、侵袭迁移和周期凋亡的影响。结果显示,过表达UHRF1能够显著促进前列腺癌细胞的增殖、侵袭和迁移能力,并抑制细胞凋亡,调控细胞处于G2/M期,并且上调DNMT1表达水平,下调p16^(INK4A)表达水平,而沉默UHRF1的表达则作用相反。总之,UHRF1可能通过抑制p16^(INK4A)的表达促进前列腺癌细胞的增殖、侵袭和迁移,抑制细胞凋亡,UHRF1有可能成为前列腺癌潜在的治疗靶点。展开更多
基金the National Natural Science Foundation of China (Grant No. 51372214)Hunan Provincial Natural Science Foundation of China (Grant No. 2020JJ4240)the Doctoral startup foundation of Hunan Institute of Engineering。
文摘We study the propagation properties of a probe field in an aligned asymmetric triple quantum dot molecule with both sides inter-dot tunneling coupling effect. It is shown that the probe field can form optical soliton due to the destructive quantum interference induced by the quantum inter-dot tunneling coupling effect. Interestingly, these optical solitons can be stored and retrieved by adjusting single or double inter-dot tunneling coupling effect, different from that light memory in the ultra-cold atom system. Furthermore, we also find that the amplitude of the stored optical soliton can be adjusted by the strength of the single or double inter-dot tunneling coupling. It is possible to improve the stability and the fidelity of the optical information in the process of the storage and retrieval in semiconductor quantum dots devices.
文摘为了探讨泛素样含植物同源结构域和环指结构域1蛋白(ubiquitin-like with PHD and ring finger domains 1,UHRF1)对前列腺癌PC-3细胞生物学功能的影响及相关机制,我们用含有UHRF1和shRNA-UHRF1的慢病毒颗粒分别感染PC-3细胞,构建UHRF1沉默或过表达的稳转细胞株模型。利用实时荧光定量PCR(RT-qPCR)、蛋白免疫印迹(Western blot)和细胞免疫荧光实验验证感染后UHRF1表达水平和检测UHRF1对DNMT1、p16^(INK4A)的mRNA及蛋白表达水平的影响。CCK-8实验、划痕实验、Transwell实验和流式细胞术实验研究UHRF1对PC-3细胞增殖、侵袭迁移和周期凋亡的影响。结果显示,过表达UHRF1能够显著促进前列腺癌细胞的增殖、侵袭和迁移能力,并抑制细胞凋亡,调控细胞处于G2/M期,并且上调DNMT1表达水平,下调p16^(INK4A)表达水平,而沉默UHRF1的表达则作用相反。总之,UHRF1可能通过抑制p16^(INK4A)的表达促进前列腺癌细胞的增殖、侵袭和迁移,抑制细胞凋亡,UHRF1有可能成为前列腺癌潜在的治疗靶点。
