It has been demonstrated that there are multiple opioid receptors in the brain of animals and men. The relationship between various subtype receptors and their physiological functions and the true biochemical basis ab...It has been demonstrated that there are multiple opioid receptors in the brain of animals and men. The relationship between various subtype receptors and their physiological functions and the true biochemical basis about the subtypes are the most important topics by neurobiologists. Cros’s laboratory first reported that human placenta contained unique specific k opioid binding sites. Later, Ahmed made further progress.展开更多
We have reported that 3-(β-phenylethyl)-9β-methoxy-9α-(m-propionoxyphenyl)-3-azabicyclo [3.3.1] nonane (coded name; P-7548) was a new potent analgesic. Its potency was 2000 times that of morphine (mice, Lp., hot pl...We have reported that 3-(β-phenylethyl)-9β-methoxy-9α-(m-propionoxyphenyl)-3-azabicyclo [3.3.1] nonane (coded name; P-7548) was a new potent analgesic. Its potency was 2000 times that of morphine (mice, Lp., hot plate). Pharmacological tests further proved that P-7548 characterized its high potency, rapid onset and long展开更多
It has been demonstrated that the stereospecific opiate binding sites do exist in the central nervous system of animals and man. One of the most interesting tasks is to purify the receptor to homogenity. As a matter o...It has been demonstrated that the stereospecific opiate binding sites do exist in the central nervous system of animals and man. One of the most interesting tasks is to purify the receptor to homogenity. As a matter of fact, an opiate receptor clings tightly to cell membranes and is difficult to solubilize. Moreover, such a receptor is unusually minute.The progress in this field has been retarded. Recently,several laboratories succeeded in solubilizing opiate receptor by using various detergents.展开更多
文摘It has been demonstrated that there are multiple opioid receptors in the brain of animals and men. The relationship between various subtype receptors and their physiological functions and the true biochemical basis about the subtypes are the most important topics by neurobiologists. Cros’s laboratory first reported that human placenta contained unique specific k opioid binding sites. Later, Ahmed made further progress.
文摘We have reported that 3-(β-phenylethyl)-9β-methoxy-9α-(m-propionoxyphenyl)-3-azabicyclo [3.3.1] nonane (coded name; P-7548) was a new potent analgesic. Its potency was 2000 times that of morphine (mice, Lp., hot plate). Pharmacological tests further proved that P-7548 characterized its high potency, rapid onset and long
文摘It has been demonstrated that the stereospecific opiate binding sites do exist in the central nervous system of animals and man. One of the most interesting tasks is to purify the receptor to homogenity. As a matter of fact, an opiate receptor clings tightly to cell membranes and is difficult to solubilize. Moreover, such a receptor is unusually minute.The progress in this field has been retarded. Recently,several laboratories succeeded in solubilizing opiate receptor by using various detergents.
