消化性溃疡(peptic ulcer disease)包含胃溃疡与十二指肠溃疡,其中胃溃疡泛指胃黏膜发生溃疡病灶。造成胃溃疡的主要因素有幽门螺旋菌与非类固醇消炎止痛药(nonsteroidal anti-inflammatory drugs, NSAIDs)等。益生菌长年被研究具肠胃...消化性溃疡(peptic ulcer disease)包含胃溃疡与十二指肠溃疡,其中胃溃疡泛指胃黏膜发生溃疡病灶。造成胃溃疡的主要因素有幽门螺旋菌与非类固醇消炎止痛药(nonsteroidal anti-inflammatory drugs, NSAIDs)等。益生菌长年被研究具肠胃道保健的效果,故本研究以复合益生菌作为初次筛选具减缓NSAIDs造成胃溃疡的益生菌。试验采用8周龄ICR品系之雄性小鼠,分为正常组、负对照组、正对照组(10 mg/kg Omeprazole)、以及8组的复合益生菌组(20.4 mg/kg/day)。除正常组外,其余小鼠于喂食试验物29天后,再连续10天,每天管喂500 mg/bw Aspirin诱发胃溃疡,并于第40天牺牲进行胃部溃疡程度分析。结果在胃部溃疡面积、溃疡指数、溃疡治愈率及病理总和评分分析中,以复合菌Lactobacillus plantarum GKD7和Pediococcus acidilactici GKA4的组合最具显著改善现象。故未来可针对复合菌株GKD7/GKA4做单只菌株于胃部保健的深入机制研究。 Peptic ulcer disease includes gastriculcer (GU) and duodenal ulcer. GU generally refers to ulcer lesions in thegastric mucosa. The main factors that cause GU are Helicobacter pylori and nonsteroidal anti-inflammatory drugs(NSAIDs). Probiotics have been studied for many years with the effects ongastrointestinal health. Therefore, we first screened complex probiotics forthe effects on reducing the NSAIDs-induced GU. 8-week-old ICR male mice weredivided into a normal control group, a negative control group, a positivecontrol group (10 mg/kg Omeprazole), and 8 groups of complex lactic acidbacteria (20.4 mg/kg/day). Except for the normal control group, mice were fedwith probiotics or saline for 29 days, then 10 consecutive days with additionof 500 mg/bw/day Aspirin to induce GU. On the 40th day, mice were sacrificedfor GU analysis. In the analysis of GU area,ulcer index, ulcer curative ratio, and pathological score, the combination of Lactobacillus plantarum GKD7 and Pediococcus acidilactici GKA4 was the most sign展开更多
本研究为评估葡萄王生技股份有限公司(Grape King Bio Ltd.)生产之乳酸菌于抗疲劳功效的效果。实验将35只雄性ICR品系小鼠,以随机方式分为7组(n = 5):空白对照组(Vehicle)、乳酸菌GKJ1、乳酸菌GKK1、乳酸菌GKK3、乳酸菌GKK4、乳酸菌GKEX...本研究为评估葡萄王生技股份有限公司(Grape King Bio Ltd.)生产之乳酸菌于抗疲劳功效的效果。实验将35只雄性ICR品系小鼠,以随机方式分为7组(n = 5):空白对照组(Vehicle)、乳酸菌GKJ1、乳酸菌GKK1、乳酸菌GKK3、乳酸菌GKK4、乳酸菌GKEX,以及乳酸菌GKY5。连续喂食约40天不同乳酸菌菌株,并于试验第29至39天,分别进行前肢抓力、运动力竭分析、以及监测运动后血乳酸(lactate)、血尿素氮(blood urea nitrogen, BUN)变化。结果显示,测试之乳酸菌菌株中,以植物乳杆菌(Lactiplantibacillus plantarum) GKK1和短乳酸杆菌(Levilactobacillus brevis) GKEX与Vehicle相比,具有显著提升前肢抓力、运动力竭时间,以及维持较低的运动后血乳酸和血尿氮素。此外,更具显著提升肝脏及肌肉中的肝醣。综观上述结果,植物乳酸杆菌L. plantarum GKK1与短乳酸杆菌L. brevis GKEX具有提升运动耐力及降低运动疲劳指标的潜力,可应用于运动促进相关的保健品开发。展开更多
文摘消化性溃疡(peptic ulcer disease)包含胃溃疡与十二指肠溃疡,其中胃溃疡泛指胃黏膜发生溃疡病灶。造成胃溃疡的主要因素有幽门螺旋菌与非类固醇消炎止痛药(nonsteroidal anti-inflammatory drugs, NSAIDs)等。益生菌长年被研究具肠胃道保健的效果,故本研究以复合益生菌作为初次筛选具减缓NSAIDs造成胃溃疡的益生菌。试验采用8周龄ICR品系之雄性小鼠,分为正常组、负对照组、正对照组(10 mg/kg Omeprazole)、以及8组的复合益生菌组(20.4 mg/kg/day)。除正常组外,其余小鼠于喂食试验物29天后,再连续10天,每天管喂500 mg/bw Aspirin诱发胃溃疡,并于第40天牺牲进行胃部溃疡程度分析。结果在胃部溃疡面积、溃疡指数、溃疡治愈率及病理总和评分分析中,以复合菌Lactobacillus plantarum GKD7和Pediococcus acidilactici GKA4的组合最具显著改善现象。故未来可针对复合菌株GKD7/GKA4做单只菌株于胃部保健的深入机制研究。 Peptic ulcer disease includes gastriculcer (GU) and duodenal ulcer. GU generally refers to ulcer lesions in thegastric mucosa. The main factors that cause GU are Helicobacter pylori and nonsteroidal anti-inflammatory drugs(NSAIDs). Probiotics have been studied for many years with the effects ongastrointestinal health. Therefore, we first screened complex probiotics forthe effects on reducing the NSAIDs-induced GU. 8-week-old ICR male mice weredivided into a normal control group, a negative control group, a positivecontrol group (10 mg/kg Omeprazole), and 8 groups of complex lactic acidbacteria (20.4 mg/kg/day). Except for the normal control group, mice were fedwith probiotics or saline for 29 days, then 10 consecutive days with additionof 500 mg/bw/day Aspirin to induce GU. On the 40th day, mice were sacrificedfor GU analysis. In the analysis of GU area,ulcer index, ulcer curative ratio, and pathological score, the combination of Lactobacillus plantarum GKD7 and Pediococcus acidilactici GKA4 was the most sign
