Objective To study the interruptive effect of hepatitis B virus (HBV) specific immunolobulin (HBIG) before delivery in attempt to prevent intrauterine transmission of HBV.Methods Nine hundred and eighty HBsAg carri...Objective To study the interruptive effect of hepatitis B virus (HBV) specific immunolobulin (HBIG) before delivery in attempt to prevent intrauterine transmission of HBV.Methods Nine hundred and eighty HBsAg carrier pregnant women were randomly divided into HBIG group and control group. Each subject in the HBIG group received 200 IU or 400 IU of HBIG intramuscularly at 3, 2 and 1 month before delivery. The subjects in the control group did not receive any specific treatment. All newborn infants received 100 IU of HBIG intramascularly after venous blood samples were taken at birth and 2 weeks after birth, followed by 30 μg plasma-derived HB vaccine or 5 μg recombinant yeast-derived hepatitis B vaccine at 1, 2 and 7 months of age. Blood tests were performed for all the lying-in women and their neonates. Blood specimens were tested for HBsAg and HBeAg by enzyme immunoassay. All infants were followed up for 1 year.Results In the HBIG group, 491 neonates were born to 487 HBV carrier mothers; and in the control group, 496 neonates were born to 493 HBV carrier mothers. The rates of intrauterine transmission in the two groups were 14.3% and 5.7% respectively (χ2=20.280, P<0.001), and the rates of chronic hepatitis B in the two groups were 2.2% and 7.3% respectively (χ2=13.696, P<0.001). The high risk factors of intrauterine HBV infection included HBsAg HBeAg double positive and HBV DNA positive in the peripheral blood of pregnant women.Conclusion HBV infection in the uterus may be interrupted by injecting multiple intramuscular HBIG injections before delivery without causing any side-effects.展开更多
目的探讨以知-信-行模式构建的"五师共管"家庭社区医生团队服务模式的应用及效果,为社区妊娠期糖尿病(GDM)患者管理提供依据。方法选取2015年1月起至2016年8月苏州市立医院4家直属社区卫生服务中心管理的122例GDM患者作为研...目的探讨以知-信-行模式构建的"五师共管"家庭社区医生团队服务模式的应用及效果,为社区妊娠期糖尿病(GDM)患者管理提供依据。方法选取2015年1月起至2016年8月苏州市立医院4家直属社区卫生服务中心管理的122例GDM患者作为研究对象,根据自愿原则分为"五师共管"组72例和对照组50例。"五师共管"组采用"五师共管"模式进行干预,对照组采用常规健康教育和随访监测干预,时间均从妊娠建卡明确GDM诊断至产后6个月。比较两组不同时间点GDM防治知识知晓情况,自我管理技术正确情况,空腹血糖(FPG)、餐后2 h血糖(2h PG)、糖化血红蛋白(HbA1C)水平、母儿并发症及不良妊娠结局等指标。采用SPSS 18.0软件进行t检验、χ2检验。结果预产期1个月内"五师共管"组GDM防治知识总知晓率(91.7%)、自我管理技术总正确率(91.1%)均高于对照组(分别为78.3%、78.6%),差异均有统计学意义(P<0.01)。预产期1个月内、产后3及6个月"五师共管"组坚持饮食调控、坚持运动、定期监测血糖的比例高于对照组,差异均有统计学意义(P<0.05,P<0.01)。预产期1个月内,"五师共管"组FPG、2 h PG和HbA1C水平均低于对照组,差异均有统计学意义(P<0.05)。产后6个月,"五师共管"组口服葡萄糖耐量试验(OGTT)后2 h PG达标率(97.2%)较对照组(86.0%)高,差异有统计学意义(P<0.01)。"五师共管"组新生儿并发症总发生率(16.7%)低于对照组(36.0%),孕产妇并发症及不良妊娠结局总发生率(20.8%)也低于对照组(44.0%),差异均有统计学意义(P<0.05)。结论"五师共管"模式能够明显改善GDM患者在孕期及产后健康相关行为,降低糖代谢异常的发生,减少母儿并发症及不良妊娠结局的发生,有一定的推广价值。展开更多
With the method of Urea inclusion,the content of α Linolenic acid (ALA) from perilla oil,Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA) from fish oil were enriched.The results showed that with once separa...With the method of Urea inclusion,the content of α Linolenic acid (ALA) from perilla oil,Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA) from fish oil were enriched.The results showed that with once separation,the purity of ALA and EPA+DHA was concentrated to 87.1% and above 70% respectively,the optimum conditions being given.展开更多
基金TheresearchwassupportedbyagrantfromtheMinistryofPublicHealth ,China (No 970 30 2 2 3) .
文摘Objective To study the interruptive effect of hepatitis B virus (HBV) specific immunolobulin (HBIG) before delivery in attempt to prevent intrauterine transmission of HBV.Methods Nine hundred and eighty HBsAg carrier pregnant women were randomly divided into HBIG group and control group. Each subject in the HBIG group received 200 IU or 400 IU of HBIG intramuscularly at 3, 2 and 1 month before delivery. The subjects in the control group did not receive any specific treatment. All newborn infants received 100 IU of HBIG intramascularly after venous blood samples were taken at birth and 2 weeks after birth, followed by 30 μg plasma-derived HB vaccine or 5 μg recombinant yeast-derived hepatitis B vaccine at 1, 2 and 7 months of age. Blood tests were performed for all the lying-in women and their neonates. Blood specimens were tested for HBsAg and HBeAg by enzyme immunoassay. All infants were followed up for 1 year.Results In the HBIG group, 491 neonates were born to 487 HBV carrier mothers; and in the control group, 496 neonates were born to 493 HBV carrier mothers. The rates of intrauterine transmission in the two groups were 14.3% and 5.7% respectively (χ2=20.280, P<0.001), and the rates of chronic hepatitis B in the two groups were 2.2% and 7.3% respectively (χ2=13.696, P<0.001). The high risk factors of intrauterine HBV infection included HBsAg HBeAg double positive and HBV DNA positive in the peripheral blood of pregnant women.Conclusion HBV infection in the uterus may be interrupted by injecting multiple intramuscular HBIG injections before delivery without causing any side-effects.
文摘目的探讨以知-信-行模式构建的"五师共管"家庭社区医生团队服务模式的应用及效果,为社区妊娠期糖尿病(GDM)患者管理提供依据。方法选取2015年1月起至2016年8月苏州市立医院4家直属社区卫生服务中心管理的122例GDM患者作为研究对象,根据自愿原则分为"五师共管"组72例和对照组50例。"五师共管"组采用"五师共管"模式进行干预,对照组采用常规健康教育和随访监测干预,时间均从妊娠建卡明确GDM诊断至产后6个月。比较两组不同时间点GDM防治知识知晓情况,自我管理技术正确情况,空腹血糖(FPG)、餐后2 h血糖(2h PG)、糖化血红蛋白(HbA1C)水平、母儿并发症及不良妊娠结局等指标。采用SPSS 18.0软件进行t检验、χ2检验。结果预产期1个月内"五师共管"组GDM防治知识总知晓率(91.7%)、自我管理技术总正确率(91.1%)均高于对照组(分别为78.3%、78.6%),差异均有统计学意义(P<0.01)。预产期1个月内、产后3及6个月"五师共管"组坚持饮食调控、坚持运动、定期监测血糖的比例高于对照组,差异均有统计学意义(P<0.05,P<0.01)。预产期1个月内,"五师共管"组FPG、2 h PG和HbA1C水平均低于对照组,差异均有统计学意义(P<0.05)。产后6个月,"五师共管"组口服葡萄糖耐量试验(OGTT)后2 h PG达标率(97.2%)较对照组(86.0%)高,差异有统计学意义(P<0.01)。"五师共管"组新生儿并发症总发生率(16.7%)低于对照组(36.0%),孕产妇并发症及不良妊娠结局总发生率(20.8%)也低于对照组(44.0%),差异均有统计学意义(P<0.05)。结论"五师共管"模式能够明显改善GDM患者在孕期及产后健康相关行为,降低糖代谢异常的发生,减少母儿并发症及不良妊娠结局的发生,有一定的推广价值。
文摘With the method of Urea inclusion,the content of α Linolenic acid (ALA) from perilla oil,Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA) from fish oil were enriched.The results showed that with once separation,the purity of ALA and EPA+DHA was concentrated to 87.1% and above 70% respectively,the optimum conditions being given.
