Objective To evaluate the effect on inflammatory response and dose-response relationship of lidocaine pretreatment in Endotoxin-induced acute lung injury rabbit model.Methods Thirty anesthetized rabbits were randomly ...Objective To evaluate the effect on inflammatory response and dose-response relationship of lidocaine pretreatment in Endotoxin-induced acute lung injury rabbit model.Methods Thirty anesthetized rabbits were randomly divided into six groups(n = 5 each).Lung injury was induced in rabbits by intravenous infusion of Escbericbia coli endotoxin(100 μg/kg over a 60 min period).10 min before infusion of endotoxin, one group was assigned to receive intravenous infusion of saline(as control);while others received intravenous infusion of lidocaine at different concentrations. Homodynamics, arterial oxygen tension and cytokines concentrations in plasma were recorded. The lung wet-to-dry-weight ratio was analyzed as an index of pulmonary edema. Light microscopic findings (lung injury score) were compared in the six groups. Results Endotoxin caused marked decrease in arterial oxygen tension, and increase in the lung wet-to dry-weight ratio, interleukin-6,interleukin-10 and tumor necrosis factor-α in plasma. Lidocaine pretreatment attenuated these changes significantly (P<0.05). Endotoxin increased lung injury score. These changes were attenuated by lidocaine significantly in relation with its doses(P<0.05). Conclusion Results suggest that intravenous lidocaine pretreatment might attenuates inflammatory response in relation with its doses in endotoxin-induced acute lung injury rabbit model.展开更多
文摘目的观察依托咪酯乳剂全麻诱导对高龄和休克病人血液动力学的影响.方法选择100例ASAⅡ～Ⅲ级老年或出血性休克的手术病人,用芬太尼4μg/kg、维库溴铵0.1mg/kg、依托咪酯0.2～0.3 mg/kg进行麻醉诱导,监测平均动脉压(MAP)、心率(HR)、每搏量(SV)、每膊指数(SI)、心排血量(CO)、心脏指数(CI)、心脏加速度(ACI)、左心功(LCW)及左心功指数(LCWI).分别于诱导前、静注依托咪酯1、2、3min以及气管内插管后3min,记录上述指标.结果与诱导前比较,静注依托咪酯后1～3 min MAP、HR、SV、SI、CO、CI、ACI、LCW、LCWI均有不同程度降低(P＜0.05).气管插管后3 min,MAP、HR、CO、CI、ACI较诱导前明显升高(P＜0.05),其余指标均恢复至基础值水平.整个诱导过程中心功能的各指标的最大改变均不超过20%.结论依托咪酯麻醉诱导对高龄和休克病人血液动力学的影响轻微.对于血液动力学不稳定病人,依托咪酯是麻醉诱导的较佳选择.
文摘Objective To evaluate the effect on inflammatory response and dose-response relationship of lidocaine pretreatment in Endotoxin-induced acute lung injury rabbit model.Methods Thirty anesthetized rabbits were randomly divided into six groups(n = 5 each).Lung injury was induced in rabbits by intravenous infusion of Escbericbia coli endotoxin(100 μg/kg over a 60 min period).10 min before infusion of endotoxin, one group was assigned to receive intravenous infusion of saline(as control);while others received intravenous infusion of lidocaine at different concentrations. Homodynamics, arterial oxygen tension and cytokines concentrations in plasma were recorded. The lung wet-to-dry-weight ratio was analyzed as an index of pulmonary edema. Light microscopic findings (lung injury score) were compared in the six groups. Results Endotoxin caused marked decrease in arterial oxygen tension, and increase in the lung wet-to dry-weight ratio, interleukin-6,interleukin-10 and tumor necrosis factor-α in plasma. Lidocaine pretreatment attenuated these changes significantly (P<0.05). Endotoxin increased lung injury score. These changes were attenuated by lidocaine significantly in relation with its doses(P<0.05). Conclusion Results suggest that intravenous lidocaine pretreatment might attenuates inflammatory response in relation with its doses in endotoxin-induced acute lung injury rabbit model.
