目的探讨不同方法建立双足大鼠脊柱侧弯动物模型的特点及意义。方法脱离哺乳期SD大鼠40只,随机分为4组各10只。通过手术完全切除大鼠的前肢及尾部。对照组10只,单纯制作双足大鼠动物模型。设立3个实验组,其中6-巯基嘌呤组腹腔内注射6-...目的探讨不同方法建立双足大鼠脊柱侧弯动物模型的特点及意义。方法脱离哺乳期SD大鼠40只,随机分为4组各10只。通过手术完全切除大鼠的前肢及尾部。对照组10只,单纯制作双足大鼠动物模型。设立3个实验组,其中6-巯基嘌呤组腹腔内注射6-巯基嘌呤(30 m L/kg),低褪黑素组腹腔内注射2-苯基-N-乙酰色胺(0.2 mg/kg),肉毒毒素组椎旁肌注射肉毒毒素。对4组实验动物手术前后的脊柱曲度指数(Cobb角)、椎体高度变化情况及脊柱侧弯特点进行比较评估。结果所有实验动物均存活至完成脊柱侧弯建模实验。对照组未发生脊柱侧弯,3个实验组双足鼠均发生了脊柱侧弯。4组大鼠Cobb角均呈增加趋势,6-巯基嘌呤组Cobb角的幅度最大;4组椎体高度均呈升高趋势,与对照组比较,6-巯基嘌呤组和肉毒毒素组椎体高度丢失,低褪黑素组高度增加,4组组间、时点间、组间·时点间交互作用差异均有统计学意义(P<0.05)。结论腹腔注射6-巯基嘌呤、2-苯基-N-乙酰色胺以及椎旁肌注射肉毒毒素均可成功建立SD双足大鼠脊柱侧弯动物模型。展开更多
骨巨细胞瘤（giant cell tumor of bone，GCT）又称破骨细胞瘤，是一种较常见的骨肿瘤，好发于长骨骨端。5％～10％的骨巨细胞瘤呈侵袭性生长，术后易复发。本文通过回顾性分析19例长骨骨巨细胞瘤多层螺旋CT（MSCT）资料，以提高对长骨...骨巨细胞瘤（giant cell tumor of bone，GCT）又称破骨细胞瘤，是一种较常见的骨肿瘤，好发于长骨骨端。5％～10％的骨巨细胞瘤呈侵袭性生长，术后易复发。本文通过回顾性分析19例长骨骨巨细胞瘤多层螺旋CT（MSCT）资料，以提高对长骨骨巨细胞瘤的诊断和鉴别诊断能力。展开更多
A Svec^[1] obtained some results on surfaces in E^3 by the method of quasi-analytic function.This paper gives several global properties on closed surfaces with qenus zero by the similar method, obtains the main resul...A Svec^[1] obtained some results on surfaces in E^3 by the method of quasi-analytic function.This paper gives several global properties on closed surfaces with qenus zero by the similar method, obtains the main result that a closed special Weingartan surface with qeus zero in E^3 is a sphere,gives wo conditions for two surfaces with congrence property,and proves that there is not closed Bonnet surface with qenus zero.展开更多
文摘目的探讨不同方法建立双足大鼠脊柱侧弯动物模型的特点及意义。方法脱离哺乳期SD大鼠40只,随机分为4组各10只。通过手术完全切除大鼠的前肢及尾部。对照组10只,单纯制作双足大鼠动物模型。设立3个实验组,其中6-巯基嘌呤组腹腔内注射6-巯基嘌呤(30 m L/kg),低褪黑素组腹腔内注射2-苯基-N-乙酰色胺(0.2 mg/kg),肉毒毒素组椎旁肌注射肉毒毒素。对4组实验动物手术前后的脊柱曲度指数(Cobb角)、椎体高度变化情况及脊柱侧弯特点进行比较评估。结果所有实验动物均存活至完成脊柱侧弯建模实验。对照组未发生脊柱侧弯,3个实验组双足鼠均发生了脊柱侧弯。4组大鼠Cobb角均呈增加趋势,6-巯基嘌呤组Cobb角的幅度最大;4组椎体高度均呈升高趋势,与对照组比较,6-巯基嘌呤组和肉毒毒素组椎体高度丢失,低褪黑素组高度增加,4组组间、时点间、组间·时点间交互作用差异均有统计学意义(P<0.05)。结论腹腔注射6-巯基嘌呤、2-苯基-N-乙酰色胺以及椎旁肌注射肉毒毒素均可成功建立SD双足大鼠脊柱侧弯动物模型。
文摘A Svec^[1] obtained some results on surfaces in E^3 by the method of quasi-analytic function.This paper gives several global properties on closed surfaces with qenus zero by the similar method, obtains the main result that a closed special Weingartan surface with qeus zero in E^3 is a sphere,gives wo conditions for two surfaces with congrence property,and proves that there is not closed Bonnet surface with qenus zero.
