Rhizama Chuanxiong is a kind of traditional medicinal herb used to promote blood circulation and eliminate wind to relieve pain. In this work, nano Rhizoma Chuanxiong particles were successfully prepared by high speed...Rhizama Chuanxiong is a kind of traditional medicinal herb used to promote blood circulation and eliminate wind to relieve pain. In this work, nano Rhizoma Chuanxiong particles were successfully prepared by high speed centrifugal sheering (HSCS) pulverizer. The influence of processing parameters on the size of Rhizama Chuanxiong particles and the different properties between nano Rhizoma Chuanxiong particles and original fine powder were systematically studied by ZetaPALS light scattering granulometric analyzer and optical microscope. The content of effective ingredient tetramethylpyrazine (TMP) was determined by high-performance liquid chromatography (HPLC). The results illustrate that general Rhizama Chuanxiong powder can be ultrafinely ground to nanometer within 50 min, and the cellular tissues of Rhizoma Chuanxiong are broken into pieces and dispersed stably and homogeneously after being ultrafinely ground. In addition, the active ingredients can dissolve out directly and fully, and the extraction ratio of TMP is increased 32.2% by HSCS processing.展开更多
基金Project (50272047) supported by the National Natural Science Foundation of China
文摘Rhizama Chuanxiong is a kind of traditional medicinal herb used to promote blood circulation and eliminate wind to relieve pain. In this work, nano Rhizoma Chuanxiong particles were successfully prepared by high speed centrifugal sheering (HSCS) pulverizer. The influence of processing parameters on the size of Rhizama Chuanxiong particles and the different properties between nano Rhizoma Chuanxiong particles and original fine powder were systematically studied by ZetaPALS light scattering granulometric analyzer and optical microscope. The content of effective ingredient tetramethylpyrazine (TMP) was determined by high-performance liquid chromatography (HPLC). The results illustrate that general Rhizama Chuanxiong powder can be ultrafinely ground to nanometer within 50 min, and the cellular tissues of Rhizoma Chuanxiong are broken into pieces and dispersed stably and homogeneously after being ultrafinely ground. In addition, the active ingredients can dissolve out directly and fully, and the extraction ratio of TMP is increased 32.2% by HSCS processing.
