含SET结构域蛋白2(SET domain-containing protein 2,SETD2)基因是表观遗传调节中的一个重要基因,其编码的SETD2蛋白是唯一一个参与组蛋白3第36位赖氨酸甲基化修饰的三甲基转移酶;对基因组的研究表明,SETD2基因在多种恶性肿瘤中发生突...含SET结构域蛋白2(SET domain-containing protein 2,SETD2)基因是表观遗传调节中的一个重要基因,其编码的SETD2蛋白是唯一一个参与组蛋白3第36位赖氨酸甲基化修饰的三甲基转移酶;对基因组的研究表明,SETD2基因在多种恶性肿瘤中发生突变。最初,SETD2在肾透明细胞癌、脑胶质瘤和乳腺癌等实体瘤中被发现。近年来,越来越多的研究表明SETD2可能在调节造血干细胞的功能以及造血系统正常发育过程中也起着重要的作用,其失活突变可促进多种血液系统恶性肿瘤(如髓系、淋巴系白血病以及淋巴瘤)的发生和发展以及耐药的产生。因此,阐明SETD2促进血液系统疾病的分子作用机制,对于血液系统疾病的诊断及治疗具有重大意义。本文就SETD2在血液系统恶性疾病的研究进展进行综述。展开更多
Novel The Memory keeper's Daughter tells the story when a blizzard forces,Dr.David delivered for his wife Nora,then a pair of twins came into his life.It was the happiest thing for the family.But David,by his doct...Novel The Memory keeper's Daughter tells the story when a blizzard forces,Dr.David delivered for his wife Nora,then a pair of twins came into his life.It was the happiest thing for the family.But David,by his doctor's keen judgment,the girl had Down-syndrome.In order to protect his family also to protect himself,David decided to ask Caroline,a nurse who secretly loved him to send her daughter to a welfare home.Then told Nora their daughter had died.Nora immersed herself in sorrow.Who knows,the white lie had made his family broken.Wife cannot get out of the shadow of losing her daughter,she started to drinking for seeking comfort and hav?ing affairs,tried her best to paralyze her mind.David worked longer and longer hours,to the detriment of his marriage.Their only son Paul grew up in such family without love.The causes of the tragedy of David and Nora's marriage are various but can be summarized three points,Vulnerability,Lie,Imbalanced.展开更多
文摘含SET结构域蛋白2(SET domain-containing protein 2,SETD2)基因是表观遗传调节中的一个重要基因,其编码的SETD2蛋白是唯一一个参与组蛋白3第36位赖氨酸甲基化修饰的三甲基转移酶;对基因组的研究表明,SETD2基因在多种恶性肿瘤中发生突变。最初,SETD2在肾透明细胞癌、脑胶质瘤和乳腺癌等实体瘤中被发现。近年来,越来越多的研究表明SETD2可能在调节造血干细胞的功能以及造血系统正常发育过程中也起着重要的作用,其失活突变可促进多种血液系统恶性肿瘤(如髓系、淋巴系白血病以及淋巴瘤)的发生和发展以及耐药的产生。因此,阐明SETD2促进血液系统疾病的分子作用机制,对于血液系统疾病的诊断及治疗具有重大意义。本文就SETD2在血液系统恶性疾病的研究进展进行综述。
文摘Novel The Memory keeper's Daughter tells the story when a blizzard forces,Dr.David delivered for his wife Nora,then a pair of twins came into his life.It was the happiest thing for the family.But David,by his doctor's keen judgment,the girl had Down-syndrome.In order to protect his family also to protect himself,David decided to ask Caroline,a nurse who secretly loved him to send her daughter to a welfare home.Then told Nora their daughter had died.Nora immersed herself in sorrow.Who knows,the white lie had made his family broken.Wife cannot get out of the shadow of losing her daughter,she started to drinking for seeking comfort and hav?ing affairs,tried her best to paralyze her mind.David worked longer and longer hours,to the detriment of his marriage.Their only son Paul grew up in such family without love.The causes of the tragedy of David and Nora's marriage are various but can be summarized three points,Vulnerability,Lie,Imbalanced.
