Background The relationship between contrast-induced acute kidney injury(CI-AKI)and long-term mortality of anemia patients still remain controversial.Previous researches indicated that inconsistent definition may cont...Background The relationship between contrast-induced acute kidney injury(CI-AKI)and long-term mortality of anemia patients still remain controversial.Previous researches indicated that inconsistent definition may contributed to this problem.Methods This study conducted a retrospective cohort study enrolling 5,406 patients with anemia undergoing coronary angiography or percutaneous coronary intervention between January 2007 and December 2018 in Guangdong Provincial People’s Hospital.The CI-AKI was evaluated according to two definitions:1.CI-AKIA:With a serum creatinine(SCr)elevation of 25%or 0.5 mg/d L from baseline in the first 72 hours after procedure;2:CI-AKIB:With a SCr elevation of 50%or 0.3 mg/d L from baseline in the first 72 hours after procedure.The endpoint was all-cause mortality.Univariable and multivariable Cox regression model were used to explore association between long-term all-cause mortality and CI-AKI.Population attributable risks(PARs)based on two different CI-AKI definitions for mortality were calculated.Results CI-AKIAwas associated with 1.36 fold risk of long-term death(HR:1.36,95%CI:1.18-1.57),while CI-AKIBwas associated with 1.32 fold risk of long-term death(HR:1.32,95%CI:1.13-1.54).Between two definitions,the prevalence of CI-AKI was higher for CI-AKIA(16.7%),compared with CI-AKIB(12.6%).For the PARs,PAR based on CI-AKIA(PAR:5.65,95%CI:2.91-8.67),was higher than that based on CI-AKIB(PAR:3.87,95%CI:1.61-6.36).Conclusions Patients complicated with CI-AKI had a higher risk of mortality than those without CI-AKI in all definitions.The prevalence and PAR of CI-AKI were higher when it was defined as CI-AKIA.CI-AKIAwas considered as a better definition to identify anemia patients with higher risk of CI-AKI and higher risk of CI-AKI-associated mortality.展开更多
基金supported by Beijing Lisheng Cardiovascular Health Foundation Pilot Fund(No.LHJJ20141751)The National Science Foundation of China(No.81970311 and No.82070360)+1 种基金Study on the Function and Mechanism of the Potential Target for Early Warning of Cardio-renal Syndrome after Acute Myocardial Infarction Based on Translational Medicine(No.DFJH201919)Clinical Medicine Research Fund of Guangdong Province(No.2019ZX01)。
文摘Background The relationship between contrast-induced acute kidney injury(CI-AKI)and long-term mortality of anemia patients still remain controversial.Previous researches indicated that inconsistent definition may contributed to this problem.Methods This study conducted a retrospective cohort study enrolling 5,406 patients with anemia undergoing coronary angiography or percutaneous coronary intervention between January 2007 and December 2018 in Guangdong Provincial People’s Hospital.The CI-AKI was evaluated according to two definitions:1.CI-AKIA:With a serum creatinine(SCr)elevation of 25%or 0.5 mg/d L from baseline in the first 72 hours after procedure;2:CI-AKIB:With a SCr elevation of 50%or 0.3 mg/d L from baseline in the first 72 hours after procedure.The endpoint was all-cause mortality.Univariable and multivariable Cox regression model were used to explore association between long-term all-cause mortality and CI-AKI.Population attributable risks(PARs)based on two different CI-AKI definitions for mortality were calculated.Results CI-AKIAwas associated with 1.36 fold risk of long-term death(HR:1.36,95%CI:1.18-1.57),while CI-AKIBwas associated with 1.32 fold risk of long-term death(HR:1.32,95%CI:1.13-1.54).Between two definitions,the prevalence of CI-AKI was higher for CI-AKIA(16.7%),compared with CI-AKIB(12.6%).For the PARs,PAR based on CI-AKIA(PAR:5.65,95%CI:2.91-8.67),was higher than that based on CI-AKIB(PAR:3.87,95%CI:1.61-6.36).Conclusions Patients complicated with CI-AKI had a higher risk of mortality than those without CI-AKI in all definitions.The prevalence and PAR of CI-AKI were higher when it was defined as CI-AKIA.CI-AKIAwas considered as a better definition to identify anemia patients with higher risk of CI-AKI and higher risk of CI-AKI-associated mortality.
